A5091398777- Cancer survivorship and care
- Cancer-related cognitive impairment studies
- Cancer Treatment and Pharmacology
- Colorectal Cancer Treatments and Studies
- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Viral-associated cancers and disorders
- Atrial Fibrillation Management and Outcomes
- Multiple and Secondary Primary Cancers
- Gallbladder and Bile Duct Disorders
- Sleep and related disorders
- Lymphoma Diagnosis and Treatment
- Heparin-Induced Thrombocytopenia and Thrombosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- CNS Lymphoma Diagnosis and Treatment
- Renal cell carcinoma treatment
- Frailty in Older Adults
- Teratomas and Epidermoid Cysts
- Cancer Cells and Metastasis
- Heterotopic Ossification and Related Conditions
- Circadian rhythm and melatonin
- Hypertrophic osteoarthropathy and related conditions
- Pelvic floor disorders treatments
- Parvovirus B19 Infection Studies
- Hernia repair and management
Klinikum Chemnitz
2024
Hôpital Paul-Brousse
2005-2020
Bnai Zion Medical Center
2020
Assistance Publique – Hôpitaux de Paris
2009-2020
Betsi Cadwaladr University Health Board
2018
University Medical Center Rizk Hospital
2013-2014
Université Paris-Saclay
2009
Tailgut cysts are rare diseases but can be challenging to manage.This is a case report of tailgut cyst, in 42 year old female. The cyst was incidentally detected on imaging, and treated with Kraske surgical approach.Hereby, we review the relevant information present medical literature about incidence, methods diagnosis, treatment options management plans.Surgical should tailored individually for each patient, based advantages disadvantages approach.
Psychosocial symptoms often cluster together, are refractory to treatment, and impair health-related quality of life (HR-QoL) in cancer patients. The contribution circadian rhythm alterations systemic has been overlooked cancer, despite a causal link shown under jet lag shift work conditions. We investigated whether the rest-activity provides reliable objective estimate most frequent patient-reported outcome measures (PROMs).Two datasets were used, each involving concomitant 3-day time...
To assess the impact of chronomodulated irinotecan fluorouracil-leucovorin and oxaliplatin (chronoIFLO4) delivered at home on daily life patients with cancer in real time using a home-based e-Health multifunction multiuser platform. This involved multidimensional telemonitoring circadian rest-activity rhythm (CircAct), sleep, patient-reported outcome measures, body weight changes (BWCs).Patients received chronoIFLO4 fortnightly home. Patients completed 19-item MD Anderson Symptom Inventory...
Telehealth solutions can improve the safety of ambulatory chemotherapy, contributing to maintenance patients at their home, hence improving well-being, all while reducing health care costs. There is, however, need for a practicable multilevel monitoring solution, encompassing relevant outputs involved in pathophysiology chemotherapy-induced toxicity. Domomedicine embraces delivery complex and medical procedures patient's home based on modern technologies, thus it offers an integrated...
Abstract Subjective sleep assessment in cancer patients poorly correlates with actigraphy parameters that usually encompass multiple nights. We aimed to determine the objective measures best correlated subjective ratings on a night-by-night basis patients. Thirty-one daily self-rated disturbances using single dedicated item of MD Anderson Symptom Inventory (0–10 scale) 18 other items, and continuously wore wrist actigraph for 30 days. Objective were computed from nighttime series, reported...
Abstract Background FOLFIRINOX is a pillar first-line regimen in the treatment of pancreatic cancer. Historically, biliary tract cancer (BTC) and have been treated similarly with gemcitabine alone or combined platinum compound. With growing evidence supporting role fluoropyrimidines BTC, we aimed at assessing outcomes patients (pts) BTC on frontline FOLFIRINOX. Methods We retrospectively analyzed data all our consecutive locally advanced (LA) metastatic (M) who were registered to receive as...
FOLFIRINOX is one of the most effective reference regimens in 1st line treatment locally advanced (LA) and metastatic pancreatic cancer (mPC), despite its high toxicity. We evaluated our real-life experience with "patient-tailored intent to treat FOLFIRINOX" patients LA or mPC compared other reports along pivotal phase III trial.We analyzed data from all consecutive ductal adenocarcinoma treated dose-modified 2016 at Paul Brousse University Hospital. Irinotecan was administered whenever...
A 20-year-old woman presented with bone and joint pain for 2 months. She had a history of localized nasopharyngeal carcinoma treated radiotherapy 1 year earlier. Physical examination was normal the exception digital clubbing hands feet. The computed tomography (CT) scan thorax revealed multiple pulmonary opacities suggesting metastatic lesions (Fig 1A). technetium-99m (Tc) showed typical uptake periosteal reaction long bones corresponding to hypertrophic osteoarthropathy (HPO; Fig 2A)....
Background . Hypercoagulable disorders can lead to deep vein thrombosis (DVT), arterial or embolization, and early recurrent bypass graft failure. The purpose of this study was identify whether diabetes increased the likelihood heparin-induced platelet factor 4 antibodies in at risk vascular patients. Methods We reviewed clinical data on 300 consecutive A hypercoagulable workup performed if patients presented with (1) bypass/graft (<30 days), (2) multiple thrombosis, (3) a history DVT,...
Transanal small bowel evisceration remains a rarely recorded emergent situation in the scientific literature. This article describes rather seldom complication of non-treated long standing rectal prolapse presenting form transanal due to perforation.
e22039 Background: CTCs are considered as useful indicators of tumor aggressiveness, patient prognosis, and treatment effectiveness monitoring. Detection in blood is difficult due to the extreme rarity found PVB. Peripheral veins carrying merge with intrathoracic caval nearly all patients metastatic cancer have a central venous access device. We hypothesized that chances detecting might be higher CVB versus PVB having richer CTC content for anatomical reasons. This study compared numbers...
499 Background: FOLFIRINOX is an effective reference regimen in the 1 st line treatment of advanced PC, despite its high level toxicity. We report recent data from pts treated with this at Paul Brousse university hospital. Methods: From January to December 2016, 37 PC received patient-tailored as intent treat chemotherapy. The first 3 courses were administered without irinotecan if initial serum bilirubin was ≥ 1.5 x upper limit normal. Oxaliplatin stopped for severe sensory neuropathy....
e14582 Background: Effective treatment options are limited for MCC pts after failure on systemic chemotherapy. The combination of I, O and F as, chronoHAI could revert prior resistance through exploiting circadian differences between healthy liver metastases. This study aimed at defining the efficacy safety this schedule in heavily pretreated with liver-predominant MCC. Methods: Data from all consecutive unresectable treated standard chemotherapy were reviewed. Pts received I (180mg/m² day 1...
e19513 Background: PTLD is a rare complication of organ transplantation, but it can jeopardize the transplantation outcome. Methods: Paul Brousse University Hospital largest liver center in France. We retrospectively analyzed data from all patients who experienced and treated our hematology/oncology department last 10 years. Results: 16 cases occurred after various intervals following transplant without correlation with type underlying disease or immunosuppressive treatment. Overall, had...
Current wrist-actigraphy parameters poorly identify the cancer patients, who subjectively report poor sleep. However, most studies average multiple nights of data, not accounting for changes that can occur while on treatment. Hence, our aim was to understand, a night-by-night basis, objective measures which best correlated with subjective sleep complaints. We investigated associations between duration, timing, efficiency, latency and fragmentation, objectively measured by wrist-actigraphy,...
Abstract Placement of ICDs, permanent pacemakers, and biventricular devices is performed under fluoroscopic guidance. Implantable device leads can cause tricuspid regurgitation (TR) when they interfere with leaflet motion. In the past, we had experience 2 cases RV lead who severe TR; one repositioning other needed surgery. Aim: Evaluation TR after right ventricular (RV) implantation to check if echocardiographic guidance for adequate positioning. Methods: Seventy six patients trans-thoracic...
e24026 Background: Cancer is mainly a disease of the elderly with more than 75% patients aged 65 years and at diagnosis. Comprehensive geriatric assessment (CGA) usually used to assess cancer patients¹. However, its sensitivity in predicting their outcome questionable. Methods: We investigated whether specific oncologic markers could predict chemotherapy toxicity cancer-related death prospective single center study 110 chemo-naive advanced cancer. All underwent CGA. Frailty as defined by...