A5068491867- Circadian rhythm and melatonin
- Cancer survivorship and care
- Sleep and related disorders
- Cancer-related cognitive impairment studies
- Mobile Health and mHealth Applications
- Neurological disorders and treatments
- Heart Rate Variability and Autonomic Control
- Botulinum Toxin and Related Neurological Disorders
- Sleep and Work-Related Fatigue
- Cystic Fibrosis Research Advances
- Photoreceptor and optogenetics research
- Dietary Effects on Health
- Childhood Cancer Survivors' Quality of Life
- Parkinson's Disease Mechanisms and Treatments
- Context-Aware Activity Recognition Systems
- Cancer Treatment and Pharmacology
- Pulmonary Hypertension Research and Treatments
- Child Nutrition and Feeding Issues
- Infrared Thermography in Medicine
- Neurogenetic and Muscular Disorders Research
- Sleep and Wakefulness Research
- High Altitude and Hypoxia
- Time Series Analysis and Forecasting
- Palliative Care and End-of-Life Issues
- Telemedicine and Telehealth Implementation
University of Warwick
2017-2022
Inserm
2016-2020
Université Paris-Saclay
2020
Betsi Cadwaladr University Health Board
2018
Institut National de Recherche en Santé Publique
2017
University of Bedfordshire
2016
Wearable computing devices allow collection of densely sampled real-time information on movement enabling researchers and medical experts to obtain objective non-obtrusive records actual activity a subject in the real world over many days. Our interest here is motivated by use data for evaluating monitoring circadian rhythmicity subjects research chronobiology chronotherapeutic healthcare. In order translate from such high-volume arising we propose Markov modelling approach which (i)...
Psychosocial symptoms often cluster together, are refractory to treatment, and impair health-related quality of life (HR-QoL) in cancer patients. The contribution circadian rhythm alterations systemic has been overlooked cancer, despite a causal link shown under jet lag shift work conditions. We investigated whether the rest-activity provides reliable objective estimate most frequent patient-reported outcome measures (PROMs).Two datasets were used, each involving concomitant 3-day time...
To assess the impact of chronomodulated irinotecan fluorouracil-leucovorin and oxaliplatin (chronoIFLO4) delivered at home on daily life patients with cancer in real time using a home-based e-Health multifunction multiuser platform. This involved multidimensional telemonitoring circadian rest-activity rhythm (CircAct), sleep, patient-reported outcome measures, body weight changes (BWCs).Patients received chronoIFLO4 fortnightly home. Patients completed 19-item MD Anderson Symptom Inventory...
Telemonitoring of circadian and sleep cycles could identify shift workers at increased risk poor health, including cancer cardiovascular diseases, thus supporting personalized prevention.
Background: Experimental and epidemiologic studies have shown that circadian clocks' disruption can play an important role in the development of cancer metabolic diseases. The cellular clocks outside brain are effectively coordinated by body temperature rhythm. We hypothesized concurrent measurements rest-activity rhythms would assess coordination individual patients, thus enabling integration biological into precision medicine. Objective: objective was to evaluate healthy subjects patients...
Telehealth solutions can improve the safety of ambulatory chemotherapy, contributing to maintenance patients at their home, hence improving well-being, all while reducing health care costs. There is, however, need for a practicable multilevel monitoring solution, encompassing relevant outputs involved in pathophysiology chemotherapy-induced toxicity. Domomedicine embraces delivery complex and medical procedures patient's home based on modern technologies, thus it offers an integrated...
BACKGROUND. Circadian timing of treatments can largely improve tolerability and efficacy in patients. Thus, drug metabolism cell cycle are controlled by molecular clocks each coordinated the core body temperature 24-hour rhythm, which is generated hypothalamic pacemaker. Individual circadian phase currently estimated with questionnaire-based chronotype, center-of-rest time, dim light melatonin onset (DLMO), or (CBT) maximum (acrophase) minimum (bathyphase).
The dichotomy index (I < O), a quantitative estimate of the circadian regulation daytime activity and sleep, predicted overall cancer survival emergency hospitalization, supporting its integration in mHealth platform. Modifiable causes I O deterioration below 97.5%—(I O)low—were sought 25 gastrointestinal patients 33 age- sex-stratified controls. Rest-activity temperature were tele-monitored with wireless chest sensor, while daily activities, meals, sleep self-reported for one week....
Abstract Subjective sleep assessment in cancer patients poorly correlates with actigraphy parameters that usually encompass multiple nights. We aimed to determine the objective measures best correlated subjective ratings on a night-by-night basis patients. Thirty-one daily self-rated disturbances using single dedicated item of MD Anderson Symptom Inventory (0–10 scale) 18 other items, and continuously wore wrist actigraph for 30 days. Objective were computed from nighttime series, reported...
Resources for management of epilepsy in Africa are extremely limited reinforcing the need to develop innovative strategies optimizing care. Studies have shown that prevalence low- and middle-income countries is substantially greater than more resourced countries. The objective this report was demonstrate mobile Health (mHealth) technologies potential improve Africa.The feasibility technology-based home monitoring investigated an observational study 40 children with refractory or associated...
Background Circadian rhythms in body temperature coordinate peripheral molecular clocks, hence they could potentially predict optimal treatment timing (chronotherapy) individual patients. parameters chest surface (Chesttemp) were recorded remotely and real time through the use of wearable sensors. Methods The dynamics circadian oscillations Chesttemp core (Coretemp) their moderation by sex age analysed 38 men 50 women, aged 21–78 years. In two studies (ST1 ST2), was measured every minute...
Up to 70% of individuals diagnosed with adult-onset idiopathic focal cervical dystonia (AOIFCD) report difficulties sleep. Larger cohort studies using wrist-worn accelerometer devices have emerged as an alternative smaller polysomnography studies, in order evaluate sleep architecture.To measure activity during the sleep/wake cycle, wore a consumer-grade wrist device (Garmin vivosmart 4) continuously over 7 days on their non-dominant wrist, while completing daily diary and standardised...
Preserving function and independence to perform activities of daily living (ADL) is critical for patients carers manage the burden care improve quality life. In children with rare diseases, video recording ADLs offer opportunity collect patients' experience in a real-life setting accurately reflect treatment effectiveness on outcomes that matter families.
The Vendée Globe is a non-stop, unassisted, single-handed round the world sailing race. It regarded as toughest race, requiring high cognitive functioning and constant alertness. Little known about amount of sleep restriction nutritional deficit experienced at sea effects that fatigue have on sailors' performance. This report aimed to investigate these aspects by monitoring one female participants latest Globe. Sleep, food intake stress were self-reported daily using specific app. Cognitive...
<title>Abstract</title> <bold>Background:</bold> Primary Ciliary Dyskinesia (PCD) is a rare genetic condition that causes an impairment in mucus clearance due to abnormal function of airway cilia. This results recurrent respiratory infections and progressive lung damage. Symptoms are managed via prescribed techniques (ACTs) which essential for preventing exacerbations improving quality-of-life (QOL), as well antibiotics treat infections. Regular exercise healthy lifestyle also recommended....
Sleep disturbance is an increasingly recognized non-motor trait in dystonia, with varying findings reported to date. Here, we examine sleep a UK Biobank derived dystonia cohort using subjective self-reported symptoms and objective accelerometer-derived measures, comparison control population.
<b>Background:</b> The 6-Minute Walk Test (6MWT) is an established endpoint in pulmonary hypertension trials. Shorter and digital formats could prove advantageous decentralised patient-centred <b>Aims:</b> To evaluate the agreement of shorter duration walk tests with 6MWT. compare a novel 1MWT gold-standard 6MWT via multiple quantitative/qualitative metrics. <b>Methods:</b> distance walked at each minute was compared. Patients completed wearable device (Garmin Venu 2) paired to app...
Background: Telemonitoring of circadian and sleep cycles could identify shift workers at increased risk poor health, including cancer cardiovascular diseases, thus supporting personalized prevention.Methods: The Circadiem cross-sectional study aimed determining early warning signals health alteration in hospital nightshifters (NS) versus dayshifters (DS, alternating morning afternoon shifts). Circadian rhythmicity activity, sleep, temperature was telemonitored on work free days for one week....
TPS4673 Background: Pancreatic cancer is a poor prognosis and fast-growing cancer, whose five-year survival 6% in Europe the US. FOLFIRINOX has been established as reference medical treatment for this disease worldwide, yet it also causes leuko-neutropenia, thrombocytopenia, diarrhea, anorexia, asthenia, weight loss, peripheral sensory neuropathy. Its indication usually limited to patients having WHO performance status of 0 or 1. This often interrupted once Grade 3-4 clinical hematological...
Perturbations of circadian rhythms have been related to cancer progression and worsening metabolic diseases. This paper aims at optimizing the analytical methods suited for detection such perturbations using skin temperature signals as a biomarker. Five control subjects were evaluated in this pilot study. Skin was recorded every five minutes four days. Using novel thoracic infrared sensor. Four different interpolation compared order replace missing values help subsequently prolong sensor...
Circadian rhythms undergo high perturbations due to cancer progression and worsening of metabolic diseases.This paper proposes an original method for detecting such using a novel thoracic temperature sensor.Such infrared sensor records the skin every five minutes, although some data might be missing.In this pilot study, control subjects were evaluated over four days recordings.In order overcome problem missing data, first different interpolation methods compared.Using helps covering gaps...
Current wrist-actigraphy parameters poorly identify the cancer patients, who subjectively report poor sleep. However, most studies average multiple nights of data, not accounting for changes that can occur while on treatment. Hence, our aim was to understand, a night-by-night basis, objective measures which best correlated with subjective sleep complaints. We investigated associations between duration, timing, efficiency, latency and fragmentation, objectively measured by wrist-actigraphy,...