A5082902582- Glioma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Microtubule and mitosis dynamics
- MicroRNA in disease regulation
- Neurogenesis and neuroplasticity mechanisms
- Neuropeptides and Animal Physiology
- Caveolin-1 and cellular processes
- Cancer Cells and Metastasis
- Receptor Mechanisms and Signaling
- Ferroptosis and cancer prognosis
- Cytokine Signaling Pathways and Interactions
- Neuroblastoma Research and Treatments
- Cancer Mechanisms and Therapy
- Cellular Mechanics and Interactions
- Nanoplatforms for cancer theranostics
- Epigenetics and DNA Methylation
- Hedgehog Signaling Pathway Studies
- Cancer, Stress, Anesthesia, and Immune Response
- Circular RNAs in diseases
- Pharmacological Receptor Mechanisms and Effects
- Immune cells in cancer
- Neuroscience and Neuropharmacology Research
- Cancer-related molecular mechanisms research
- NF-κB Signaling Pathways
- Cell Image Analysis Techniques
University of California, San Francisco
2011-2023
Neurological Surgery
2012-2019
UCSF Helen Diller Family Comprehensive Cancer Center
2010-2019
Cancer Research Center
2016
McGill University
2016
St. Jude Children's Research Hospital
2016
Heidelberg University
2016
University Hospital Heidelberg
2016
Institute of Cancer Research
2016
German Cancer Research Center
2016
Abstract Background Glioblastoma multiforme (GBM) is an invariably fatal central nervous system tumor despite treatment with surgery, radiation, and chemotherapy. Further insights into the molecular cellular mechanisms that drive GBM formation are required to improve patient outcome. MicroRNAs emerging as important regulators of differentiation proliferation, have been implicated in etiology a variety cancers, yet role microRNAs remains poorly understood. In this study, we investigated...
Previous work has shown that voluntary running increases cell proliferation and neurogenesis in the dentate gyrus of adult hippocampus. Here we report long-term for 24 days results a down-regulation hippocampal progenitor to one-half level nonrunning controls compared with fivefold increase seen after 9 (short-term running). The negative effects on were prevented by restricting daily distances (by 30-50%) during days. Long-term response hypothalamic-pituitary-adrenal axis, an adrenal gland...
PI3K/mTOR inhibitors inhibit angiogenesis by blocking MYCN-dependent paracrine signaling between tumor and endothelial cells.
Abstract High grade gliomas (HGG) are classified into four subgroups based on transcriptional signatures and phenotypic characteristics. In particular, the proneural-to-mesenchymal transition (PMT) is associated with increased malignancy, poor prognosis, disease recurrence, but underlying causes of PMT still unclear. this study, we investigated whether radiotherapy promotes using a genetically engineered mouse model proneural HGG. We found that cranial ionizing radiation induced robust...
Abstract Opioids have previously been shown to affect proliferation and differentiation in various neural cell types. In the present study, cultured rat adult hippocampal progenitors (AHPs) were release β‐endorphin. Membrane preparations of AHPs found bind [ 125 I]β‐endorphin, immunoreactivity for mu‐ delta‐opioid receptors (MORs DORs), but not kappa‐opioid (KORs), was on cells culture. Both DNA content 3 H]thymidine incorporation reduced after a 48‐h incubation with 100 µ m naloxone, 10...
The weak immunogenicity of gliomas presents a barrier for effective immunotherapy. Na/H exchanger isoform 1 (NHE1) maintains alkaline intracellular pH (pHi) glioma cells and acidic microenvironment. In addition, NHE1 is expressed in tumor-associated microglia macrophages (TAMs) involved protumoral communications between TAMs. Therefore, we hypothesize that plays role developing tumor resistance immunosuppressive this study, investigated the efficacy pharmacological inhibition on...
Abstract cDNA microarrays and two‐dimensional gel‐electrophoresis in combination with mass spectrometry, were used to screen alterations mRNA protein levels, respectively, cerebral cortex of MK‐801‐treated rats. The rats divided two groups; group 1 (short‐term treated) 2 (long‐term treated). In 1, four genes up‐regulated five down‐regulated. 2, seven six the levels one was increased eight proteins reduced. Several altered (casein kinase glutamic acid decarboxylase, synaptotagmin, gamma...
Significance Glioblastoma is the most common and aggressive form of brain cancer. GBM patients typically respond poorly to conventional therapies. The tumor-suppressor protein 53 pathway disrupted in a majority cases. Using mouse model that mimics progression human GBM, we evaluate optimize therapeutic efficacy functional p53 restoration gliomas. We show therapy animal as well cells improved markedly by an episodic dosing regimen circumvents selective pressure for adaptive resistance when...
Glioblastoma multiforme (GBM) carries a poor prognosis and continues to lack effective treatments. stem cells (GSCs) drive tumor formation, invasion, drug resistance and, as such, are the focus of studies identify new therapies for disease control. Here, we involvement IKK NF-κB signaling in maintenance GSCs. Inhibition this pathway impairs self-renewal analyzed tumorsphere formation GBM expansion brain slice culture. Interestingly, both canonical non-canonical branches shown contribute...
Identifying cellular programs that drive cancers to be stem-like and treatment resistant is critical improving outcomes in patients. Here, we demonstrate constitutive extracellular signal-regulated kinase 1/2 (ERK1/2) activation sustains a state glioblastoma (GBM), the most common primary malignant brain tumor. Pharmacological inhibition of ERK1/2 restores neurogenesis during murine astrocytoma formation, inducing neuronal differentiation tumorspheres. Constitutive globally regulates miRNA...
Abstract Voluntary running in mice and forced treadmill rats have been shown to increase the amount of proliferating cells hippocampus. Little is known as yet about mechanisms involved these processes. It well that endogenous opioid system affected during other forms physical exercise. In this study, we evaluated involvement opioids regulation hippocampal proliferation non‐running voluntary rats. Nine days wheel was compared with spontaneously hypertensive (SHR), a rat strain run...
Glioblastoma (GBM) is the most common primary malignant brain tumor of adults and confers a poor prognosis due, in part, to diffuse invasion cells. Heparan sulfate (HS) glycosaminoglycans, present on cell surface extracellular matrix, regulate signaling pathways cell-microenvironment interactions. In GBM, expression HS glycosaminoglycans enzymes that their function are altered, but actual content structure unknown. However, inhibition glycosaminoglycan emerging as promising therapeutic...
Glioblastoma (GBM) is the most common malignant primary brain tumor. Radiotherapy fails to eliminate subpopulations of stem-like tumor-propagating cells (TPC), resulting in tumor regrowth. To identify kinases that promote TPC self-renewal rather than increasing proliferation human GBM cultures, we screened a library 54 nonselective tool compounds and determined their kinase inhibitor profiles vitro. Most inhibited aurora (AURK) activity blocked self-renewal, while inducing cell...
Slow-cycling and treatment-resistant cancer cells escape therapy, providing a rationale for regrowth recurrence in patients. Much interest has focused on identifying the properties of slow-cycling tumor glioblastoma (GBM), most common lethal primary brain tumor. Despite aggressive ionizing radiation (IR) treatment with alkylating agent temozolomide (TMZ), GBM patients invariably relapse ultimately succumb to disease. In patient biopsies, we demonstrated that expressing proliferation markers...