A5048505585- Chemokine receptors and signaling
- Cancer Mechanisms and Therapy
- Cancer Immunotherapy and Biomarkers
- Glioma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Proteoglycans and glycosaminoglycans research
- Cancer Genomics and Diagnostics
- Glycosylation and Glycoproteins Research
- Single-cell and spatial transcriptomics
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Angiogenesis and VEGF in Cancer
- RNA modifications and cancer
- Genetic factors in colorectal cancer
- Ubiquitin and proteasome pathways
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Extracellular vesicles in disease
- Histone Deacetylase Inhibitors Research
- Caveolin-1 and cellular processes
- Carbohydrate Chemistry and Synthesis
Neurological Surgery
2016-2023
University of California, San Francisco
2016-2023
University of Washington
2021-2023
Cancer Research Center
2017
UCSF Helen Diller Family Comprehensive Cancer Center
2016
Abstract Pleomorphic xanthoastrocytoma ( PXA ) is an astrocytic neoplasm that typically well circumscribed and can have a relatively favorable prognosis. Tumor progression to anaplastic WHO grade III ), however, associated with more aggressive biologic behavior worse The factors drive are largely unknown. We performed comprehensive genomic profiling on set of 23 s from 19 patients, including 15 . Four patients had tumor tissue multiple recurrences, two progression. find genetically defined...
Abstract Cell-free DNA (cfDNA) has the potential to inform tumor subtype classification and help guide clinical precision oncology. Here we develop Griffin, a framework for profiling nucleosome protection accessibility from cfDNA study phenotype of tumors using as low 0.1x coverage whole genome sequencing data. Griffin employs GC correction procedure tailored variable fragment sizes, which generates better representation chromatin improves accuracy cancer detection classification. We...
Abstract Background IDH-mutant diffuse gliomas are heterogeneous, and improved methods for optimal patient therapeutic stratification needed. PI3K/AKT/mTOR signaling activity can drive disease progression potential inhibitors of the pathway available. Yet, prevalence in glioma is unclear few robust strategies to assess clinical samples exist. Methods was evaluated a retrospective cohort 132 (91 astrocytoma 41 oligodendroglioma, 1p/19q-codeleted) through quantitative multiplex immunoprofiling...
Abstract Purpose: The immunosuppressive tumor microenvironment present in the majority of diffuse glioma limits therapeutic response to immunotherapy. As determinants glioma-associated immune are relatively poorly understood, study with more robust tumor-associated responses may be particularly useful identify novel immunomodulatory factors that can promote T-cell effector function glioma. Experimental Design: We used multiplex immune-profiling, proteomic profiling, and gene expression...
Glioblastoma (GBM) is the most common primary malignant brain tumor of adults and confers a poor prognosis due, in part, to diffuse invasion cells. Heparan sulfate (HS) glycosaminoglycans, present on cell surface extracellular matrix, regulate signaling pathways cell-microenvironment interactions. In GBM, expression HS glycosaminoglycans enzymes that their function are altered, but actual content structure unknown. However, inhibition glycosaminoglycan emerging as promising therapeutic...
Abstract Cell-free DNA (cfDNA) has the potential to inform tumor subtype classification and help guide clinical precision oncology. Here we developed Griffin, a new method for profiling nucleosome protection accessibility from cfDNA study phenotype of tumors using as low 0.1x coverage whole genome sequencing (WGS) data. Griffin employs novel GC correction procedure tailored variable fragment sizes, which improves prediction chromatin accessibility. achieved excellent performance detecting in...
Glycosaminoglycans (GAGs) such as heparan sulfate and chondroitin decorate all mammalian cell surfaces. These mucopolysaccharides act coreceptors for extracellular ligands, regulating signaling, growth, proliferation, adhesion. In glioblastoma, the most common type of primary malignant brain tumor, dysregulated GAG biosynthesis results in altered chain length, sulfation patterns, ratio contributing monosaccharides. events contribute to loss normal cellular function, initiating sustaining...
<div>AbstractPurpose:<p>The immunosuppressive tumor microenvironment present in the majority of diffuse glioma limits therapeutic response to immunotherapy. As determinants glioma-associated immune are relatively poorly understood, study with more robust tumor-associated responses may be particularly useful identify novel immunomodulatory factors that can promote T-cell effector function glioma.</p>Experimental Design:<p>We used multiplex immune-profiling, proteomic...
Supplementary Figure from CXCL14 Promotes a Robust Brain Tumor-Associated Immune Response in Glioma
Supplementary Data from CXCL14 Promotes a Robust Brain Tumor-Associated Immune Response in Glioma
Supplementary Data from CXCL14 Promotes a Robust Brain Tumor-Associated Immune Response in Glioma
Supplementary Figure from CXCL14 Promotes a Robust Brain Tumor-Associated Immune Response in Glioma
Supplementary Figure from CXCL14 Promotes a Robust Brain Tumor-Associated Immune Response in Glioma
Supplementary Figure from CXCL14 Promotes a Robust Brain Tumor-Associated Immune Response in Glioma
Supplementary Figure from CXCL14 Promotes a Robust Brain Tumor-Associated Immune Response in Glioma
Supplementary Data from CXCL14 Promotes a Robust Brain Tumor-Associated Immune Response in Glioma
Supplementary Figure from CXCL14 Promotes a Robust Brain Tumor-Associated Immune Response in Glioma
Supplementary Figure from CXCL14 Promotes a Robust Brain Tumor-Associated Immune Response in Glioma
Supplementary Data from CXCL14 Promotes a Robust Brain Tumor-Associated Immune Response in Glioma
Supplementary Figure from CXCL14 Promotes a Robust Brain Tumor-Associated Immune Response in Glioma
Supplementary Figure from CXCL14 Promotes a Robust Brain Tumor-Associated Immune Response in Glioma
<div>AbstractPurpose:<p>The immunosuppressive tumor microenvironment present in the majority of diffuse glioma limits therapeutic response to immunotherapy. As determinants glioma-associated immune are relatively poorly understood, study with more robust tumor-associated responses may be particularly useful identify novel immunomodulatory factors that can promote T-cell effector function glioma.</p>Experimental Design:<p>We used multiplex immune-profiling, proteomic...
Supplementary Figure from CXCL14 Promotes a Robust Brain Tumor-Associated Immune Response in Glioma