A5080067027- Neurotransmitter Receptor Influence on Behavior
- Functional Brain Connectivity Studies
- Neural and Behavioral Psychology Studies
- Substance Abuse Treatment and Outcomes
- Mental Health Research Topics
- Heart Rate Variability and Autonomic Control
- Advanced Neuroimaging Techniques and Applications
- Cannabis and Cannabinoid Research
- Attention Deficit Hyperactivity Disorder
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neural dynamics and brain function
- Smoking Behavior and Cessation
- Memory and Neural Mechanisms
- Olfactory and Sensory Function Studies
- Child and Adolescent Psychosocial and Emotional Development
- Biochemical Analysis and Sensing Techniques
- Advanced MRI Techniques and Applications
- Transcranial Magnetic Stimulation Studies
- EEG and Brain-Computer Interfaces
- Alcohol Consumption and Health Effects
- Behavioral Health and Interventions
- Mind wandering and attention
- Nicotinic Acetylcholine Receptors Study
- Genetic Associations and Epidemiology
- Mindfulness and Compassion Interventions
Pennsylvania State University
2020-2025
Mind Research Network
2015-2024
Lovelace Respiratory Research Institute
2016-2024
Biomedical Research Institute
2019-2024
National Institute of Arthritis and Musculoskeletal and Skin Diseases
2024
KU Leuven
2023
Mental Research Institute
2019
University of New Mexico
2011-2017
Radiology Associates of Albuquerque
2015
Environmental Research Institute
2014
Contemporary perspectives on age differences in risk taking, informed by advances developmental neuroscience, have emphasized the need to examine ways which emotional and cognitive factors interact influence decision making. In present study, a diverse sample of 901 individuals between ages 10 30 were administered modified version Iowa Gambling Task, is designed measure affective Results indicate that approach behaviors (operationalized as tendency play increasingly from advantageous decks...
Poor decision-making is a hallmark of addiction, whether to substances or activities. Performance on widely used test decision-making, the Iowa Gambling Task (IGT), can discriminate controls from persons with ventral medial frontal lesions, substance-dependence, and pathological gambling. Positron emission tomography (PET) studies indicate that substance-dependent individuals show altered prefrontal activity task. Here we adapted IGT an fMRI setting hypothesis defects in processing are...
The past few years have seen an emergence of approaches that leverage temporal changes in whole-brain patterns functional connectivity (the chronnectome). In this chronnectome study, we investigate the replicability human brain's inter-regional coupling dynamics during rest by evaluating two different dynamic network (dFNC) analysis frameworks using 7 500 magnetic resonance imaging (fMRI) datasets. To quantify extent to which emergent (FC) are reproducible, characterize deriving several...
Background: Studies suggest that polymorphisms in the D4 dopamine receptor (DRD4) and opioid receptor, μ1 (OPRM1) genes are involved differential response to effects of alcohol cues. However, date, mechanisms underlie these differences remain largely unknown. Methods: Using functional magnetic resonance imaging, hemodynamic mesocorticolimbic structures after exposure tastes was contrasted with a control taste compared between DRD4 variable number tandem repeats (VNTR) genotypes OPRM1 A118G...
The inhibition of unwanted behaviors is considered an effortful and controlled ability. However, also requires the detection contexts indicating that old may be inappropriate – in other words, ability to monitor context service goals, which we refer as context-monitoring. Using behavioral, neuroimaging, electrophysiological computational approaches, tested whether motoric stopping per se cognitively-controlled process supporting response inhibition, or context-monitoring fill this role. Our...
Background Adolescence is commonly characterized by impulsivity, poor decision-making, and lack of foresight. However, the developmental neural underpinnings these characteristics are not well established. Methodology/Principal Findings To test hypothesis that adolescent behaviors linked to under-developed proactive control mechanisms, present study employed a hybrid block/event-related functional Magnetic Resonance Imaging (fMRI) Stroop paradigm combined with self-report questionnaires in...
Background: Alcohol dependence has repeatedly been associated with impulsive choice, or the inability to choose large delayed rewards over smaller, but more immediate rewards. However, neural basis of choice in alcohol use disorders (AUDs) is not well understood. Methods: One hundred fifty-one individuals a range from social drinking severe completed delay discounting task while undergoing functional magnetic resonance imaging. Participants received customized trials designed ensure an...
Abstract This pilot study investigated psilocybin-induced changes in neural reactivity to alcohol and emotional cues patients with use disorder (AUD). Participants were recruited from a phase II, randomized, double-blind, placebo-controlled clinical trial investigating psilocybin-assisted therapy (PAT) for the treatment of AUD (NCT02061293). Eleven adult completed task-based blood oxygen dependent functional magnetic resonance imaging (fMRI) approximately 3 days before 2 after receiving 25...
In a recent study of fall prevention in 301 community-living older persons (the Yale FICSIT Trial, 1990–1993), participants the murtifactorial targeted intervention (Tl) group experienced significantly fewer falls than social visit (SV) control group. present paper, authors explore relation between changes studied risk factors and occurrence falling. comparison with SV participants, Tl showed greater improvements postural blood pressure change (p = 0.01), step length 0.004), use ≥4...
Objective: The current study examined the relationship between severity of alcohol use disorders (AUDs) and neural circuits that underlie response inhibition error monitoring. In addition, we explored pre- post-inhibition trial processes to determine potential causal mechanisms responsible for disinhibition in AUDs. Method: One hundred sixty-four individuals with a range drinking from non-treatment-seeking adults problematic treatment-seeking dependence completed Go/NoGo task while...
Mindfulness-based relapse prevention (MBRP) and transcranial direct current stimulation (tDCS) have independently shown benefits for treating alcohol use disorder (AUD). Recent work suggests tDCS may enhance mindfulness. The combination of MBRP provide synergistic target both behavioral neurobiological dysfunctions in AUD. goal this double-blind sham-controlled randomized trial was to examine the efficacy a rolling group treatment combined with among individuals interested reducing their...
A bstract : Background: The mesocorticolimbic dopamine system is implicated in motivation and reward may be involved the development of alcoholism. Methods: We used functional magnetic resonance imaging to study blood oxygen level–dependent (BOLD) response alcohol‐related olfactory stimuli (AROS; odors beer whiskey) non‐alcohol‐related (NAROS; grass leather) 10 high‐risk (HR) drinkers (average drinks per week, 19.99; SD, 6.99; all with ≥2 first‐ or second‐degree alcoholic relatives) 5...
Substance-dependent individuals make poor decisions on the Iowa Gambling Task, a reward-related decision-making task that involves risk and uncertainty. Task performance depends several factors, including how sensitive are to feedback well they learn based such feedback. A physiological signal guides decision making is prediction error. The authors investigated whether disruptions in neural systems underlying error processing substance-dependent could account for modified Task.