A5075420771- Substance Abuse Treatment and Outcomes
- Alcohol Consumption and Health Effects
- Neurotransmitter Receptor Influence on Behavior
- Alcoholism and Thiamine Deficiency
- Liver Disease Diagnosis and Treatment
- Schizophrenia research and treatment
- Prenatal Substance Exposure Effects
- Eicosanoids and Hypertension Pharmacology
- Treatment of Major Depression
- Neural and Behavioral Psychology Studies
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Neuroscience and Neuropharmacology Research
- Cannabis and Cannabinoid Research
- Peroxisome Proliferator-Activated Receptors
- Attention Deficit Hyperactivity Disorder
- Obsessive-Compulsive Spectrum Disorders
- Homelessness and Social Issues
- Gambling Behavior and Treatments
- Functional Brain Connectivity Studies
- Stress Responses and Cortisol
- Neurological and metabolic disorders
- Opioid Use Disorder Treatment
- Genetic Associations and Epidemiology
- Infectious Encephalopathies and Encephalitis
Medical University of South Carolina
2015-2024
Instituto de investigación sanitaria y biomédica de Alicante
2024
Research for Action
2024
Greek Rescue Team
2024
National Institute on Alcohol Abuse and Alcoholism
1997-2021
Yale University
1982-2021
Columbia University
2021
University of New Mexico
2021
Connecticut Mental Health Center
2021
Anthem (United States)
2021
Alcohol dependence treatment may include medications, behavioral therapies, or both. It is unknown how combining these treatments impact their effectiveness, especially in the context of primary care and other nonspecialty settings.To evaluate efficacy medication, combinations for alcohol to placebo effect on overall outcome.Randomized controlled trial conducted January 2001-January 2004 among 1383 recently alcohol-abstinent volunteers (median age, 44 years) from 11 US academic sites with...
It has been suggested that a crucial dimension of alcohol “craving” includes the concept both obsessive thoughts about use and compulsive behaviors toward drinking. An interview‐based rating scale, Yale‐Brown Obsessive Compulsive Scale‐heavy drinkers (YBOCS‐hd), found useful in quantifying this alcohol‐dependent individuals. A self‐rating Drinking Scale (OCDS) developed by us as modification YBOCS‐hd. The YBOCS‐hd showed excellent interrater reliability our hands. correlation between OCDS...
Objective: To evaluate the correspondence among measures of self-reported drinking, standard biological indicators and reports collateral informants, to identify patient characteristics associated with observed discrepancies these three sources research data. Method: Using data collected from a large-scale clinical trial treatment matching alcoholics (N = 1,726), alternative outcome were compared at time admission 12 months after end treatment. Results: Patient self-reports agreed most...
Naltrexone hydrochloride treatment for alcohol dependence works some individuals but not everyone. Asn40Asp, a functional polymorphism of the mu-opioid receptor gene (OPRM1), might predict naltrexone response.To evaluate whether with alcoholism who are heterozygous (Asp40/Asn40) or homozygous (Asp40/Asp40) OPRM1 Asp40 allele respond better to naltrexone.Pharmacogenetic analysis conducted between January 1, 2001, and 31, 2004.Eleven academic sites in COMBINE Study.Recently abstinent...
The opiate antagonist drug naltrexone has been shown in a few studies with limited sample sizes to be effective when combined psychosocial therapies for the treatment of alcohol dependence. goal this study was obtain additional information regarding its efficacy pertinent alcoholic populations and well-defined therapy.In study, 131 recently abstinent alcohol-dependent outpatients were treated 12 weekly sessions manual-guided cognitive behavioral therapy either 50 mg/day (N = 68) or placebo...
<h3>Background</h3> Functional imaging studies have recently demonstrated that specific brain regions become active in cocaine addicts when they are exposed to stimuli. To test whether there regional activity differences during alcohol cue exposure between alcoholic subjects and social drinkers, we designed a functional magnetic resonance (fMRI) protocol involving alcohol-specific cues. <h3>Methods</h3> Ten non–treatment-seeking adult (2 women) (mean [SD] age, 29.9 [9.9] years) as well 10...
<h3>Importance</h3> Although an estimated 30 million people meet criteria for alcohol use disorder (AUD), few receive appropriate pharmacotherapy. A more personalized, symptom-specific, approach might improve efficacy and acceptance. <h3>Objective</h3> To examine whether gabapentin would be useful in the treatment of AUD, especially those with most withdrawal symptoms. <h3>Design, Setting, Participants</h3> This double-blind randomized clinical trial conducted between November 2014 June 2018...
The opioid antagonist, naltrexone, is reported, in single centre studies, to improve the clinical outcome of individuals with alcohol dependence participating outpatient psychosocial programmes. This first multicentre controlled study evaluate efficacy and safety naltrexone as adjunctive treatment for or abuse. Patients who met criteria (n = 169) abuse 6) were randomly assigned receive double-blind oral 50 mg daily 90) placebo 85) 12 weeks an adjunct treatment. primary variable was time...
<h3>Context</h3> Medication for the treatment of alcoholism is currently not particularly robust. Neuroimaging techniques might predict which medications could be useful in alcohol dependence. <h3>Objective</h3> To explore effect naltrexone, ondansetron hydrochloride, or combination these on cue-induced craving and ventral striatum activation. <h3>Design</h3> Functional brain imaging was conducted during cue presentation. <h3>Setting</h3> Participants were recruited from general community...
<h3>Context</h3> The<i>5-HTTLPR</i>polymorphism in the promoter region of serotonin transporter gene<i>(SLC6A4)</i>has been found to moderate several categories emotional response after stressful life events. Previous studies generally focused on its effect depressive symptoms; little is known about moderation development posttraumatic stress disorder (PTSD). <h3>Objective</h3> To examine effects childhood adversity, adult traumatic events,<i>5-HTTLPR</i>genotypes, and gene × environment...
Introduction: Some anticonvulsants ameliorate signs and symptoms of alcohol withdrawal, but have an unacceptable side effect burden. Among the advantages using anticonvulsant agents in this capacity is their purported lack interaction with that could increase psychomotor deficits, cognitive impairment, or intoxication. The aim study was to evaluate use symptom reduction gabapentin when compared lorazepam treatment withdrawal a double‐blinded randomized clinical trial. Methods: One hundred...
Of 86 alcoholic men with severe alcohol withdrawal who began a double-blind controlled study comparing carbamazepine, 800 mg/day, to oxazepam, 120 66 (carbamazepine, N = 32; 34) completed the 7-day trial. In general, drugs were found be equally efficacious in treating syndrome and not significantly different respect side effects. The subjects taking oxazepam had an increase global psychological distress from day 3 7, those carbamazepine exhibited decline. suggests that is as effective safe...
Naltrexone, an efficacious medication for alcohol dependence, does not work everyone. Symptoms such as insomnia and mood instability that are most evident during early abstinence might respond better to a different pharmacotherapy. Gabapentin may reduce these symptoms help prevent relapse. This clinical trial evaluated whether the combination of naltrexone gabapentin was than alone and/or placebo drinking cessation phase (first 6 weeks), if so, this effect persisted.A total 150...
Alcohol use disorder (AUD) is a highly prevalent public health problem associated with considerable individual and societal costs. Abstinence from alcohol the most widely accepted target of treatment for AUD, but it severely limits options could deter individuals who prefer to reduce their drinking seeking treatment. Clinical validation reduced consumption as primary outcome clinical trials critical expanding options. One potentially useful measure reduction in World Health Organization...