A5023895343- Neurotransmitter Receptor Influence on Behavior
- Tryptophan and brain disorders
- Receptor Mechanisms and Signaling
- Genetic Associations and Epidemiology
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Bipolar Disorder and Treatment
- Substance Abuse Treatment and Outcomes
- Alcohol Consumption and Health Effects
- Neuroscience and Neuropharmacology Research
- Hormonal Regulation and Hypertension
- Attachment and Relationship Dynamics
- Schizophrenia research and treatment
- Epigenetics and DNA Methylation
- Treatment of Major Depression
- Attention Deficit Hyperactivity Disorder
- Cannabis and Cannabinoid Research
- Autism Spectrum Disorder Research
- Peroxisome Proliferator-Activated Receptors
- Genetics and Neurodevelopmental Disorders
- Eating Disorders and Behaviors
- Circadian rhythm and melatonin
- Pharmacogenetics and Drug Metabolism
- Digital Mental Health Interventions
- Diet and metabolism studies
Ludwig-Maximilians-Universität München
2015-2024
LMU Klinikum
2003-2024
Virginia Commonwealth University
2020
Medical Genetics Center
2013
University of Bonn
1996-2011
Institute of Psychiatry and Neurology
2011
TU Dresden
2011
Heidelberg University
2011
University of Regensburg
2011
Central Institute of Mental Health
2011
<h3>Context</h3> Brain-derived neurotrophic factor (BDNF) modulates hippocampal plasticity, which is believed to be altered in patients with major depression. <h3>Objective</h3> To examine the effect of the<i>BDNF</i>Val66Met polymorphism on and amygdala volumes depression healthy control subjects. <h3>Design</h3> Cross-sectional comparison between controls. <h3>Setting</h3> Inpatients from Department Psychiatry Psychotherapy controls community were recruited. <h3>Participants</h3> The study...
<h3>Context</h3> Alcohol dependence is a serious and common public health problem. It well established that genetic factors play major role in the development of this disorder. Identification genes contribute to alcohol will improve our understanding mechanisms underlie <h3>Objective</h3> To identify susceptibility for through genome-wide association study (GWAS) follow-up population German male inpatients with an early age at onset. <h3>Design</h3> The GWAS tested 524 396 single-nucleotide...
Abnormal signal transduction pathways have been implicated in the pathogenesis of bipolar disorder and major depression. G-proteins are key elements these regulation cellular responses by transmission signals from receptors to effector proteins. In recent years several studies reported altered levels activities G-protein α subunits depressive patients. A recently identified polymorphism a β3 subunit (C825T) has shown be associated with increased ion transport activity. Therefore, we...
<h3>Background</h3> Substantial evidence supports a role for dysfunction of the serotonin transporter in pathogenesis major depression. Several studies have found reciprocal interactions between serotonergic system and both brain-derived neurotrophic factor glutamate, which are known to modulate or affect hippocampal morphologic characteristics. <h3>Objective</h3> To examine influence polymorphism (<i>5-HTTLPR</i>) promoter region gene on volumes patients with depression healthy controls....
ABSTRACT Alcohol dependence (AD) is an important contributory factor to the global burden of disease. The etiology AD involves both environmental and genetic factors, disorder has a heritability around 50%. aim present study was identify susceptibility genes for by performing genome‐wide association (GWAS). sample comprised 1333 male in‐patients with severe according Diagnostic Statistical Manual Mental Disorders, 4th edition, 2168 controls. These included 487 patients 1358 controls from...
Circadian and stress-response systems mediate environmental changes that affect alcohol drinking. Psychosocial stress is an risk factor for abuse. rhythm gene period 1 (Per1) targeted by hormones transcriptionally activated in corticotropin releasing factor-expressing cells. The authors hypothesized Per1 involved integrating response circadian rhythmicity explored its relevance to drinking.In mice, the effects of on ethanol intake mPer1-mutant wild-type mice were assessed. In humans, single...
<h3>Background</h3> Gilles de la Tourette Syndrome is a neurodevelopmental disorder that caused by the interaction of environment with complex genetic background. The etiology remains, so far, elusive, although multiple promising leads have been recently reported. recent implication histamine decarboxylase (<i>HDC</i>) gene, key enzyme in production, raises intriguing hypothesis possible role histaminergic dysfunction leading to TS onset. <h3>Methods</h3> Following up on finding nonsense...
The interaction between adverse life events during childhood and genetic factors is associated with a higher risk to develop major depressive disorder (MDD). One of the polymorphisms found be MDD Val66MET polymorphism brain-derived neurotrophic factor (BDNF). aim our two-center study was determine how BDNF Val66Met adversity affect volumetric measures hippocampus in healthy individuals people MDD. In this study, 62 adult patients 71 matched controls underwent high-resolution magnetic...
Impaired social functioning and autistic symptoms are characteristics of schizophrenia. The hormones oxytocin (OT) arginine-vasopressin (AVP) both modulate interaction therefore may be involved in the pathogenesis We investigated whether men with schizophrenia show altered OT AVP levels compared healthy controls (HC) autism associated levels.Forty-one non-acute 45 matched HC were enrolled. Schizophrenia was assessed Positive Negative Syndrome Scale (PANSS). Blood samples collected on 2 days,...
Background The angiotensin converting enzyme (ACE) has been repeatedly discussed as susceptibility factor for major depression (MD) and the bi-directional relation between MD cardiovascular disorders (CVD). In this context, functional polymorphisms of ACE gene have linked to depression, antidepressant treatment response, serum concentrations, well hypertension, myocardial infarction CVD risk markers. mostly investigated Ins/Del polymorphism accounts ∼40%–50% concentration variance, remaining...
Interpersonal problems and affective dysregulation are core characteristics of borderline personality disorder (BPD). BPD patients predominantly show unresolved attachment representations. The oxytocin (OT) system is associated with human social affiliative behavior, OT may be related to distinct characteristics. Here, we investigated whether representations peripheral levels in patients. Twenty-one female 20 age-, gender-, education-matched healthy controls were assessed clinical scales...