A5057716754- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Receptor Mechanisms and Signaling
- Photoreceptor and optogenetics research
- Neural dynamics and brain function
- Regulation of Appetite and Obesity
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Cannabis and Cannabinoid Research
- Sleep and Wakefulness Research
- Genetics and Neurodevelopmental Disorders
- Epigenetics and DNA Methylation
- Neuroscience and Neural Engineering
- Neuroinflammation and Neurodegeneration Mechanisms
- Transcranial Magnetic Stimulation Studies
- Neurobiology and Insect Physiology Research
- Neuroscience of respiration and sleep
- Functional Brain Connectivity Studies
- Biochemical Analysis and Sensing Techniques
- Neurotransmitter Receptor Influence on Behavior
- Barrier Structure and Function Studies
- Acute Ischemic Stroke Management
- Single-cell and spatial transcriptomics
- Cellular transport and secretion
- Advanced Vision and Imaging
Princeton University
2023-2025
Weill Cornell Medicine
2017-2024
MIND Research Institute
2016-2024
Cornell University
2011-2024
Tri-Institutional PhD Program in Chemical Biology
2018-2023
New York Hospital Queens
2019-2020
Presbyterian Hospital
2019-2020
NewYork–Presbyterian Hospital
2019-2020
The neurobiological mechanisms underlying the induction and remission of depressive episodes over time are not well understood. Through repeated longitudinal imaging medial prefrontal microcircuits in living brain, we found that spinogenesis plays a critical role sustaining specific antidepressant behavioral effects maintaining long-term remission. Depression-related behavior was associated with targeted, branch-specific elimination postsynaptic dendritic spines on projection neurons....
Anxiety disorders peak in incidence during adolescence, a developmental window that is marked by dynamic changes gene expression, endocannabinoid signaling, and frontolimbic circuitry. We tested whether genetic alterations signaling related to common polymorphism fatty acid amide hydrolase (FAAH), which alters anandamide (AEA) levels, would impact the development of circuitry implicated anxiety disorders. In pediatric imaging sample over 1,000 3- 21-y-olds, we show effects FAAH genotype...
The accumulation of small strokes has been linked to cognitive dysfunction. Although most animal models have focused on the impact arteriole occlusions, clinical evidence indicates that venule occlusions may also be important. We used two-photon excited fluorescence microscopy quantify changes in blood flow and vessel diameter capillaries after occlusion single ascending or surface cortical venules as a function connectivity between measured capillary occluded venule. Clotting was induced by...
Stress has pleiotropic physiologic effects, but the neural circuits linking stress to these responses are not well understood. Here, we describe a novel population of lateral septum neurons expressing neurotensin (LS Nts ) in mice that selectively tuned specific types stress. LS increase their activity during active escape, responding when flight is viable option, associated with freezing or immobility. Chemogenetic activation decreases food intake and body weight, without altering...
Abstract Social hierarchies exert a powerful influence on behavior, but the neurobiological mechanisms that detect and regulate hierarchical interactions are not well understood, especially at level of neural circuits. Here, we use fiber photometry chemogenetic tools to record manipulate activity nucleus accumbens-projecting cells in ventromedial prefrontal cortex (vmPFC-NAcSh) during tube test social competitions. We show vmPFC-NAcSh projections signal learned relationships, selectively...
Animals learn the value of foods on basis their postingestive effects and thereby develop aversions to that are toxic1-10 preferences those nutritious11-13. However, it remains unclear how brain is able assign credit flavours experienced during a meal with feedback signals can arise after substantial delay. Here we reveal an unexpected role for reactivation neural flavour representations in this temporal credit-assignment process. To begin, leverage fact mice associate novel14,15, but not...
Animals learn the value of foods based on their postingestive effects and thereby develop aversions to that are toxic
Sensory inputs activate sparse neuronal ensembles in the dentate gyrus of hippocampus, but how eligibility individual neurons to recruitment is determined remains elusive. We identify thousands largely bistable (CpG methylated or unmethylated) regions within gene bodies, established during mouse development. Reducing DNA methylation and proportion epialleles at compromises novel context-induced activation. Conversely, increasing frequency enhances intrinsic excitability. Single-nucleus...
Converging findings have established that the endocannabinoid (eCB) system serves as a possible target for development of new treatments complement to opioid-based treatments. Here, we show in male and female mice enhancing levels eCB, 2-arachidonoylglycerol (2-AG), through pharmacological inhibition its catabolic enzyme, monoacylglycerol lipase (MAGL), either systemically or ventral tegmental area (VTA) with JZL184, leads substantial attenuation rewarding effects opioids using conditioned...
Recent evidence shows that seizures propagate primarily through supragranular cortical layers. To selectively modify these circuits, we developed a new technique using tightly focused, femtosecond infrared laser pulses to make as small ~100 µm-wide subsurface incisions surrounding an epileptic focus. We use this "laser scalpel" produce layers focus in acute rodent seizure model. Compared with sham animals, microtransections completely blocked initiation and propagation 1/3 of all animals. In...
Abstract Converging findings have established that the endocannabinoid (eCB) system serves as a possible target for development of new treatments pain complement to opioid-based treatments. Here we show in male and female mice enhancing levels eCB, 2-arachidonoylglycerol (2-AG), through pharmacological inhibition its catabolic enzyme, monoacylglycerol lipase (MAGL), either systemically or ventral tegmental area (VTA) with JZL184, leads substantial attenuation rewarding effects opioids using...
Abstract Stress and anxiety are precipitating factors for eating disorders, but the neural basis linking stress to alterations in feeding is not well understood. Here we describe a novel population of stress-responsive neurons lateral septum (LS) mice that express neurotensin (LS NTS ) sexually dimorphic, estrous cycle-dependent manner. We used vivo imaging show LS activated by stressful experiences when flight viable option, experience associated with freezing or immobility. activation...