A5040043542- Visual perception and processing mechanisms
- Vestibular and auditory disorders
- Neural dynamics and brain function
- Ophthalmology and Eye Disorders
- Multisensory perception and integration
- Tactile and Sensory Interactions
- Glaucoma and retinal disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Olfactory and Sensory Function Studies
- Memory and Neural Mechanisms
- Neurobiology and Insect Physiology Research
- Motor Control and Adaptation
- Ocular Surface and Contact Lens
- Neural Networks and Applications
- Neuroscience, Education and Cognitive Function
- Sleep and Wakefulness Research
- Spatial Cognition and Navigation
- Gaze Tracking and Assistive Technology
- Neuroscience and Neuropharmacology Research
- Cerebral Venous Sinus Thrombosis
- EEG and Brain-Computer Interfaces
- Neural and Behavioral Psychology Studies
- Autism Spectrum Disorder Research
- Retinal Development and Disorders
- Ophthalmology and Visual Impairment Studies
New York University
2018-2024
Baylor College of Medicine
2013-2022
ORCID
2022
Rice University
2015-2019
Google (United States)
2016
Washington University in St. Louis
2004-2014
University of Washington
2010
Central Institute for the Deaf
2000-2003
University Hospital of Zurich
1993-2003
University of Mississippi Medical Center
1995-2000
The perception of self-motion direction, or heading, relies on integration multiple sensory cues, especially from the visual and vestibular systems. However, reliability information can vary rapidly unpredictably, it remains unclear how brain integrates signals given this dynamic uncertainty. Human psychophysical studies have shown that observers combine cues by weighting them in proportion to their reliability, consistent with statistically optimal schemes derived Bayesian probability...
Robust perception of self-motion requires integration visual motion signals with nonvisual cues. Neurons in the dorsal subdivision medial superior temporal area (MSTd) may be involved this sensory integration, because they respond selectively to global patterns optic flow, as well translational darkness. Using a virtual-reality system, we have characterized three-dimensional (3D) tuning MSTd neurons heading directions defined by flow alone, inertial and congruent combinations two Among 255...
Progress in science requires standardized assays whose results can be readily shared, compared, and reproduced across laboratories. Reproducibility, however, has been a concern neuroscience, particularly for measurements of mouse behavior. Here, we show that task to probe decision-making mice produces reproducible multiple We adopted head-fixed perceptual value-based decision making, training protocol experimental hardware, software, procedures. trained 140 seven laboratories three...
According to Einstein’s equivalence principle, inertial accelerations during translational motion are physically indistinguishable from gravitational experienced tilting movements. Nevertheless, despite ambiguous sensory representation of in primary otolith afferents, primate oculomotor responses appropriately compensatory for the correct component head movement. The neural computational strategies used by brain discriminate two and reliably detect were investigated vestibulo-ocular system....
Convergence of vestibular and visual motion information is important for self-motion perception. One cortical area that combines optic flow signals the ventral intraparietal (VIP). We characterized unisensory multisensory responses macaque VIP neurons to translations rotations in three dimensions. Approximately one-half cells show significant directional selectivity response flow, tuning stimuli, one-third responses. Visual direction preferences could be congruent or opposite. When stimuli...
The parieto-insular vestibular cortex (PIVC) is thought to contain an important representation of information. Here we describe responses macaque PIVC neurons three-dimensional (3D) and optic flow stimulation. We found robust both translational rotational stimuli in the retroinsular (Ri) adjacent secondary somatosensory (S2) cortices. did not respond stimulation, were similar darkness during visual fixation. Cells upper bank tip lateral sulcus (Ri S2) responded sinusoidal with modulation at...
Recent studies have shown that most neurons in the dorsal medial superior temporal area (MSTd) signal direction of self-translation (i.e., heading) response to both optic flow and inertial motion. Much less is currently known about properties MSTd during self-rotation. We characterized three-dimensional tuning while monkeys passively fixated a central, head-fixed target. Rotational stimuli were either presented using motion platform or simulated visually flow. Nearly all cells significantly...
Significance Autism is a pervasive disorder that broadly impacts perceptual, cognitive, social, and motor functioning. Across individuals, the manifests with large degree of phenotypic diversity. Here, we propose autism symptomatology reflects alterations in neural computation. Using network simulations, show reduction amount inhibition occurring through computation called divisive normalization can account for perceptual consequences reported autism, as well proposed changes extent to which...
Humans and animals can integrate sensory evidence from various sources to make decisions in a statistically near-optimal manner, provided that the stimulus presentation time is fixed across trials. Little known about whether optimality preserved when subjects choose decision (reaction-time task), nor inputs have time-varying reliability. Using reaction-time version of visual/vestibular heading discrimination task, we show behavior clearly sub-optimal quantified with traditional metrics...