Miles J. Wells
A5011852227- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Olfactory and Sensory Function Studies
- Memory and Neural Mechanisms
- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Photoreceptor and optogenetics research
- Receptor Mechanisms and Signaling
- Neural and Behavioral Psychology Studies
- Neuroendocrine regulation and behavior
- Neuroscience and Neural Engineering
- Multisensory perception and integration
- Animal testing and alternatives
- Stress Responses and Cortisol
- Retinal Development and Disorders
- Human Pose and Action Recognition
- Scientific Computing and Data Management
- Cognitive Science and Mapping
- Visual perception and processing mechanisms
- Color perception and design
- Advanced Vision and Imaging
- Zebrafish Biomedical Research Applications
- Neurotransmitter Receptor Influence on Behavior
University College London
2016-2025
National Hospital for Neurology and Neurosurgery
2019-2023
Institute of Ophthalmology
2019
Research in neuroscience increasingly relies on the mouse, a mammalian species that affords unparalleled genetic tractability and brain atlases. Here, we introduce high-yield methods for probing mouse visual decisions. Mice are head-fixed, facilitating repeatable stimulation, eye tracking, access. They turn steering wheel to make two alternative choices, forced or unforced. Learning is rapid thanks intuitive coupling of stimuli position. The decisions deliver high-quality psychometric curves...
Progress in science requires standardized assays whose results can be readily shared, compared, and reproduced across laboratories. Reproducibility, however, has been a concern neuroscience, particularly for measurements of mouse behavior. Here, we show that task to probe decision-making mice produces reproducible multiple We adopted head-fixed perceptual value-based decision making, training protocol experimental hardware, software, procedures. trained 140 seven laboratories three...
Deciding between stimuli requires combining their learned value with one's sensory confidence. We trained mice in a visual task that probes this combination. Mouse choices reflected not only present confidence and past rewards but also Their behavior conformed to model combines signal detection reinforcement learning. In the model, predicted of chosen option is product value. found precise correlates variable pre-outcome activity midbrain dopamine neurons medial prefrontal cortical neurons....
Abstract A key challenge in neuroscience is understanding how neurons hundreds of interconnected brain regions integrate sensory inputs with prior expectations to initiate movements. It has proven difficult meet this when different laboratories apply analyses recordings during behaviours. Here, we report a comprehensive set from 115 mice 11 labs performing decision-making task sensory, motor, and cognitive components, obtained 547 Neuropixels probe insertions covering 267 areas the left...
The brain can combine auditory and visual information to localize objects. However, the cortical substrates underlying audiovisual integration remain uncertain. Here, we show that mouse frontal cortex combines evidence; this combination is additive, mirroring behavior; it evolves with learning. We trained mice in an localization task. Inactivating impaired responses either sensory modality, while inactivating or parietal affected only stimuli. Recordings from >14,000 neurons indicated after...
The neural representations of prior information about the state world are poorly understood. To investigate them, we examined brain-wide Neuropixels recordings and widefield calcium imaging collected by International Brain Laboratory. Mice were trained to indicate location a visual grating stimulus, which appeared on left or right with probability alternating between 0.2 0.8 in blocks variable length. We found that mice estimate this thereby improve their decision accuracy. Furthermore,...
The visual responses of neurons in the primary cortex (V1) are influenced by animal's position environment [1-5]. V1 encode positions that co-fluctuate with those encoded place cells hippocampal area CA1 [2, 5]. This correlation might reflect a common influence non-visual spatial signals on both areas. Place CA1, indeed, do not rely only vision; their preference depends physical distance traveled [6-11] and phase 6-9 Hz theta oscillation [12, 13]. Are similarly these factors? We recorded...
Abstract Understanding brain function relies on the collective work of many labs generating reproducible results. However, reproducibility has not been systematically assessed within context electrophysiological recordings during cognitive behaviors. To address this, we formed a multi-lab collaboration using shared, open-source behavioral task and experimental apparatus. Experimenters in ten laboratories repeatedly targeted Neuropixels probes to same location (spanning secondary visual...
Understanding brain function relies on the collective work of many labs generating reproducible results. However, reproducibility has not been systematically assessed within context electrophysiological recordings during cognitive behaviors. To address this, we formed a multi-lab collaboration using shared, open-source behavioral task and experimental apparatus. Experimenters in ten laboratories repeatedly targeted Neuropixels probes to same location (spanning secondary visual areas,...
Progress in science requires standardized assays whose results can be readily shared, compared, and reproduced across laboratories. Reproducibility, however, has been a concern neuroscience, particularly for measurements of mouse behavior. Here we show that task to probe decision-making mice produces reproducible multiple We designed head-fixed combines established perceptual value-based decision making, training protocol experimental hardware, software, procedures. trained 140 seven...
Abstract Setting up an experiment in behavioral neuroscience is a complex process that often managed with ad hoc solutions. To streamline this process, we developed Rigbox, high-performance, open-source software toolbox facilitates modular approach to designing experiments ( https://github.com/cortex-lab/Rigbox ). Rigbox simplifies hardware input-output, time aligns datastreams from multiple sources, communicates remote databases, and implements visual auditory stimuli presentation. Its main...
Understanding brain function relies on the collective work of many labs generating reproducible results. However, reproducibility has not been systematically assessed within context electrophysiological recordings during cognitive behaviors. To address this, we formed a multi-lab collaboration using shared, open-source behavioral task and experimental apparatus. Experimenters in ten laboratories repeatedly targeted Neuropixels probes to same location (spanning secondary visual areas,...
Abstract Effective data management is a major challenge for neuroscience labs, and even greater collaborative projects. In the International Brain laboratory (IBL), ten experimental labs spanning 7 geographically distributed sites measure neural activity across brains of mice making perceptual decisions. Here, we report novel, modular architecture that allows users to contribute, access, analyze this collaboration. Users contribute using web-based electronic lab notebook (Alyx), which...
Summary To make accurate perceptual decisions, the brain often combines information across sensory modalities. For instance, localizing objects by integrating their image and sound. However, cortical substrates underlying this audiovisual integration remain uncertain. Here, we show that mouse frontal cortex auditory visual evidence; combination is additive, mirroring behavior; it evolves with learning. Scanning optogenetic inactivation demonstrated inactivating impaired choices based on...
Neurons in primary visual cortex (V1) are influenced by the animal’s position environment and encode positions that correlate with those encoded hippocampus (CA1). Might V1’s encoding of spatial be inherited from hippocampal regions? If so, it should depend on non-visual factors affect hippocampus, such as physical distance traveled phase theta oscillations. We recorded V1 CA1 neurons while mice ran through a virtual corridor confirmed these predictions. Spatial representations were...
Understanding brain function relies on the collective work of many labs generating reproducible results. However, reproducibility has not been systematically assessed within context electrophysiological recordings during cognitive behaviors. To address this, we formed a multi-lab collaboration using shared, open-source behavioral task and experimental apparatus. Experimenters in ten laboratories repeatedly targeted Neuropixels probes to same location (spanning secondary visual areas,...
Research in neuroscience relies increasingly on the mouse, a mammalian species that affords unparalleled genetic tractability and brain atlases. Here we introduce high-yield methods for probing mouse visual decisions. Mice are head-fixed, which facilitates repeatable stimulation, eye tracking, access. They turn steering wheel to make two-alternative choices, forced or unforced. Learning is rapid thanks intuitive coupling of stimuli position. The decisions deliver high-quality psychometric...
Setting up an experiment in behavioral neuroscience is a complex process that often managed with ad hoc solutions. To streamline this we developed Rigbox, high-performance, open-source software toolbox facilitates modular approach to designing experiments ( github.com/cortex-lab/Rigbox ). Rigbox simplifies hardware I/O, synchronizes data streams from multiple sources, communicates remote databases, and implements visual auditory stimuli presentation. Its main submodule, Signals, allows...
Summary Making efficient decisions requires combining present sensory evidence with previous reward values, and learning from the resulting outcome. To establish underlying neural processes, we trained mice in a task that probed such decisions. Mouse choices conformed to reinforcement model estimates predicted value (reward times confidence) prediction error (outcome minus value). Predicted was encoded pre-outcome activity of prelimbic frontal neurons midbrain dopamine neurons. Prediction...
Methodological advances in neuroscience have enabled the collection of massive datasets which demand innovative approaches for scientific communication. Existing platforms data storage lack intuitive tools exploration, limiting our ability to interact effectively with these brain-wide datasets. We introduce two public websites: Data and Atlas developed International Brain Laboratory provide access millions behavioral trials hundreds thousands individual neurons. These interfaces allow users...