Petrina Lau
A5088237428- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Genetics and Neurodevelopmental Disorders
- Photoreceptor and optogenetics research
- Circadian rhythm and melatonin
- RNA regulation and disease
- Sleep and Wakefulness Research
- Superconducting Materials and Applications
- Cellular transport and secretion
- Scientific Computing and Data Management
- Physics of Superconductivity and Magnetism
- Spacecraft and Cryogenic Technologies
- Particle physics theoretical and experimental studies
- Cognitive Science and Mapping
- Muon and positron interactions and applications
- Sleep and related disorders
- Visual perception and processing mechanisms
- Human Pose and Action Recognition
- Zebrafish Biomedical Research Applications
- EEG and Brain-Computer Interfaces
- Neural and Behavioral Psychology Studies
- Genetics, Aging, and Longevity in Model Organisms
- Neuroscience and Neural Engineering
- Neuroinflammation and Neurodegeneration Mechanisms
University College London
2023-2025
Wolfson Foundation
2023-2024
New York University
2024
Medical Research Council
2023
Mary Lyon Centre at MRC Harwell
2017-2020
University of Oxford
2008-2016
Memorial Sloan Kettering Cancer Center
2013
Abstract A key challenge in neuroscience is understanding how neurons hundreds of interconnected brain regions integrate sensory inputs with prior expectations to initiate movements. It has proven difficult meet this when different laboratories apply analyses recordings during behaviours. Here, we report a comprehensive set from 115 mice 11 labs performing decision-making task sensory, motor, and cognitive components, obtained 547 Neuropixels probe insertions covering 267 areas the left...
The neural representations of prior information about the state world are poorly understood. To investigate them, we examined brain-wide Neuropixels recordings and widefield calcium imaging collected by International Brain Laboratory. Mice were trained to indicate location a visual grating stimulus, which appeared on left or right with probability alternating between 0.2 0.8 in blocks variable length. We found that mice estimate this thereby improve their decision accuracy. Furthermore,...
Microtubule severing enzymes implement a diverse range of tissue-specific molecular functions throughout development and into adulthood. Although microtubule is fundamental to many dynamic neural processes, little known regarding the role family member Katanin p60 subunit A-like 1, KATNAL1, in central nervous system (CNS) function. Recent studies reporting that microdeletions incorporating KATNAL1 locus humans result intellectual disability microcephaly suggest may play prominent CNS;...
Understanding brain function relies on the collective work of many labs generating reproducible results. However, reproducibility has not been systematically assessed within context electrophysiological recordings during cognitive behaviors. To address this, we formed a multi-lab collaboration using shared, open-source behavioral task and experimental apparatus. Experimenters in ten laboratories repeatedly targeted Neuropixels probes to same location (spanning secondary visual areas,...
Loss-of-function mutations in a human AMPA receptor-associated protein, ferric chelate reductase 1-like (FRRS1L), are associated with devastating neurological condition incorporating choreoathetosis, cognitive deficits and epileptic encephalopathies. Furthermore, evidence from overexpression ex vivo studies has implicated FRRS1L receptor biogenesis, suggesting that changes glutamatergic signalling might underlie the disorder. Here, we investigated neurobehavioural correlates of disorder...
Long-term plasticity is well documented in synapses between glutamatergic principal cells the cortex both vitro and vivo. potentiation (LTP) -depression (LTD) have also been reported connections to hippocampal GABAergic interneurons expressing parvalbumin (PV+) or nitric oxide synthase (NOS+) brain slices, but these has not tested We investigated synaptically-evoked suprathreshold excitation of identified neurons CA1 area urethane-anaesthetized rats. Neurons were recorded extracellularly...
Abstract Learning to exploit the contingencies of a complex experiment is not an easy task for animals. Individuals learn in idiosyncratic manner, revising their approaches multiple times as they are shaped, or shape themselves, and potentially end up with different strategies. Their long-run learning curves therefore tantalizing target sort individualized quantitative characterizations that sophisticated modelling can provide. However, any such model requires flexible extensible structure...
A noninvasive sleep screen uncovers a Vamp2 mouse mutation with synaptic deficits underlying substantial disturbances.
The mammalian suprachiasmatic nucleus (SCN) is the principal circadian clock that synchronizes daily behavioral and physiological responses in response to environmental cues. Here, we present a protocol for harvesting mouse SCN by vibrating microtome diurnal transcriptome analysis. We describe steps entrainment, isolation of SCN, tissue preparation, slicing with vibratome, handling harvested RNA extraction. This can also be used other brain regions genomic studies.
The MICE focusing solenoids have three 4 K coolers (two for the superconducting magnet and one liquid absorber) four HTS leads that feed current to coils. produce large radial external fields when they operate with polarity of two coils in opposition (the gradient or flip mode). When at same solenoid non-flip mode), are much smaller parallel axis solenoid. worst-case magnetic field affects selection cooler leads. This can also determine height service towers house paper shows criteria used...
Methodological advances in neuroscience have enabled the collection of massive datasets which demand innovative approaches for scientific communication. Existing platforms data storage lack intuitive tools exploration, limiting our ability to interact effectively with these brain-wide datasets. We introduce two public websites: Data and Atlas developed International Brain Laboratory provide access millions behavioral trials hundreds thousands individual neurons. These interfaces allow users...
The muon ionization cooling experiment (MICE) consists of a target, beam line, pion decay channel, the MICE channel. Superconducting magnets are used in channel and This report describes progress design fabrication these magnets. three types superconducting solenoids; spectrometer solenoids, coupling solenoids focusing solenoids. being fabricated United States, China, UK respectively. to analyze before after cooling. couple sections keep contained within iris RF cavities that recover...
Summary statement In this study, we show that the loss of epilepsy-related gene Frrs1l in mice causes a dramatic reduction AMPA receptor levels at synapse. This change elicits severe motor and coordination disabilities, hyperactivity, cognitive defects, behavioural seizures abnormal electroencephalographic (EEG) patterns. Abstract Loss function mutations human receptor-associated protein, ferric chelate reductase 1-like (FRRS1L), are associated with devastating neurological condition...
The temporal resolution of existing streak cameras are limited by electron transit time dispersion. Here we present a state-of-art design compensating this to achieve breakthrough 100fs resolution.
Abstract Sleep-wake transitions are modulated through extensive subcortical networks although the precise roles of their individual components remain elusive. Using forward genetics and in vivo electrophysiology, we identified a recessive mouse mutant line characterised by reduced propensity to transition between all sleep states while profound loss total REM time was evident. The causative mutation, an Ile102Asn substitution VAMP2, associated with substantial synaptic changes vitro...