Mayo Faulkner
A5058756414- Electrical and Bioimpedance Tomography
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Neuroscience and Neural Engineering
- Neuroscience and Neuropharmacology Research
- Microfluidic and Bio-sensing Technologies
- Hemodynamic Monitoring and Therapy
- Flow Measurement and Analysis
- Photoreceptor and optogenetics research
- Receptor Mechanisms and Signaling
- Memory and Neural Mechanisms
- Olfactory and Sensory Function Studies
- Animal testing and alternatives
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Electrochemical Analysis and Applications
- Scientific Computing and Data Management
- Zebrafish Biomedical Research Applications
- Neural and Behavioral Psychology Studies
- Functional Brain Connectivity Studies
- Human Pose and Action Recognition
- Visual perception and processing mechanisms
- Cognitive Science and Mapping
- Analytical Chemistry and Sensors
- Geophysical and Geoelectrical Methods
University College London
2016-2025
Wolfson Foundation
2020-2021
Cranfield University
1994
Progress in science requires standardized assays whose results can be readily shared, compared, and reproduced across laboratories. Reproducibility, however, has been a concern neuroscience, particularly for measurements of mouse behavior. Here, we show that task to probe decision-making mice produces reproducible multiple We adopted head-fixed perceptual value-based decision making, training protocol experimental hardware, software, procedures. trained 140 seven laboratories three...
Abstract A key challenge in neuroscience is understanding how neurons hundreds of interconnected brain regions integrate sensory inputs with prior expectations to initiate movements. It has proven difficult meet this when different laboratories apply analyses recordings during behaviours. Here, we report a comprehensive set from 115 mice 11 labs performing decision-making task sensory, motor, and cognitive components, obtained 547 Neuropixels probe insertions covering 267 areas the left...
The neural representations of prior information about the state world are poorly understood. To investigate them, we examined brain-wide Neuropixels recordings and widefield calcium imaging collected by International Brain Laboratory. Mice were trained to indicate location a visual grating stimulus, which appeared on left or right with probability alternating between 0.2 0.8 in blocks variable length. We found that mice estimate this thereby improve their decision accuracy. Furthermore,...
A highly versatile Electrical Impedance Tomography (EIT) system, nicknamed the ScouseTom, has been developed. The system allows control over current amplitude, frequency, number of electrodes, injection protocol and data processing. Current is injected using a Keithley 6221 source, voltages are recorded with 24-bit EEG minimum bandwidth 3.2 kHz. Custom PCBs interface PC to measurement process, electrode addressing triggering external stimuli. performance was characterised resistor phantoms...
Recently developed probes for extracellular electrophysiological recordings have large numbers of electrodes on long linear shanks. Linear electrode arrays, such as Neuropixels probes, hundreds recording distributed over shanks that span several millimeters. Because the length probe in rodents usually cover multiple brain areas. Typical studies collate across sessions and animals. Neurons recorded different animals thus to be aligned each other a standardized coordinate system. Here, we...
Abstract Understanding brain function relies on the collective work of many labs generating reproducible results. However, reproducibility has not been systematically assessed within context electrophysiological recordings during cognitive behaviors. To address this, we formed a multi-lab collaboration using shared, open-source behavioral task and experimental apparatus. Experimenters in ten laboratories repeatedly targeted Neuropixels probes to same location (spanning secondary visual...
Understanding brain function relies on the collective work of many labs generating reproducible results. However, reproducibility has not been systematically assessed within context electrophysiological recordings during cognitive behaviors. To address this, we formed a multi-lab collaboration using shared, open-source behavioral task and experimental apparatus. Experimenters in ten laboratories repeatedly targeted Neuropixels probes to same location (spanning secondary visual areas,...
Imaging ictal and interictal activity with Electrical Impedance Tomography (EIT) using intracranial electrode mats has been demonstrated in animal models of epilepsy. In human epilepsy subjects undergoing presurgical evaluation, depth electrodes are often preferred. The purpose this work was to evaluate the feasibility EIT localise epileptogenic areas humans. accuracy localisation onset zone evaluated computer simulations 9M element FEM derived from three subjects. 5 mm radius perturbations...
Progress in science requires standardized assays whose results can be readily shared, compared, and reproduced across laboratories. Reproducibility, however, has been a concern neuroscience, particularly for measurements of mouse behavior. Here we show that task to probe decision-making mice produces reproducible multiple We designed head-fixed combines established perceptual value-based decision making, training protocol experimental hardware, software, procedures. trained 140 seven...
Electrical Impedance Tomography (EIT) is an emerging technique which has been used to image evoked activity during whisker displacement in the cortex of anaesthetised rat with a spatiotemporal resolution 200 μm and 2 ms. The aim this work was extend EIT not only from but also deeper structures active somatosensory processing, specifically ventral posterolateral (VPL) nucleus thalamus. direct response VPL following Hz forepaw stimulation were quantified using 57-channel epicortical electrode...
Electrical Impedance Tomography (EIT) is an emerging medical imaging technique which can produce tomographic images of internal impedance changes within object using non-penetrating surface electrodes. It has previously been used to image due neuronal depolarisation during evoked potentials in the rat somatosensory cortex with a resolution 2 ms and <200 μm, epicortical electrode array. The purpose this work was use elucidate intracortical spatiotemporal trajectory ictal spike-and-wave...
Electrical impedance tomography (EIT) is a medical imaging technique which reconstructs images of the internal changes within an object using non-penetrating surface electrodes. To date, EIT has been used to image fast neural during somatosensory evoked potentials and epileptiform discharges through rat cerebral cortex with resolution 2 ms <300 μm. However, activity in subcortical structures never achieved this technique. Here, we evaluated feasibility hippocampus electrodes implanted on...
Understanding brain function relies on the collective work of many labs generating reproducible results. However, reproducibility has not been systematically assessed within context electrophysiological recordings during cognitive behaviors. To address this, we formed a multi-lab collaboration using shared, open-source behavioral task and experimental apparatus. Experimenters in ten laboratories repeatedly targeted Neuropixels probes to same location (spanning secondary visual areas,...
Head imaging with electrical impedance tomography (EIT) is usually done time-differential measurements, to reduce time-invariant modelling errors. Previous research suggested that more accurate head models improved image quality, but no thorough analysis has been on the required accuracy. We propose a novel pipeline for creation of precise meshes from magnetic resonance and computed scans, which was applied four different heads. Voltages were simulated all heads perturbations magnitude,...
Electrical impedance tomography (EIT) can image changes associated with evoked physiological activity in the cerebral cortex using an array of epicortical electrodes. An change is observed as externally applied current, normally confined to extracellular space admitted into conducting intracellular during neuronal depolarisation. The response largest at DC and decreases higher frequencies due capacitative transfer current across membrane. Biophysical modelling has shown that this effect...
Electrical impedance tomography (EIT) is an imaging technique that produces tomographic images of internal changes within object using surface electrodes. It can be used to image the slow increase in cerebral tissue occurs over seconds during epileptic seizures, which attributed cell swelling due disturbances ion homeostasis following hypersynchronous neuronal firing and its associated metabolic demands. In this study, we characterised imaged response neocortical hippocampal epileptiform...
Objective. Electrical impedance tomography has the potential to image fast neural activity associated with physiological or epileptic throughout brain. These applications pose a particular challenge as expected voltage changes on electrodes are less than 1% and geometrical constraints of body under investigation mean that can not be evenly distributed around its boundary. Unlike other applications, however, information regarding location is typically available. An informative method for...
Objective: Methods have previously been reported for simultaneous EIT and EEG recording, but these relied on post-hoc signal processing to remove switching artefacts from the require dedicated hardware filters use of separate electrodes. This work aims demonstrate that an uncorrupted can be collected simultaneously with data by using frequency division multiplexing (FDM), show provides useful information when compared source localisation. Approach: A custom FDM current was created evaluated...
Understanding brain function relies on the collective work of many labs generating reproducible results. However, reproducibility has not been systematically assessed within context electrophysiological recordings during cognitive behaviors. To address this, we formed a multi-lab collaboration using shared, open-source behavioral task and experimental apparatus. Experimenters in ten laboratories repeatedly targeted Neuropixels probes to same location (spanning secondary visual areas,...
Electrical impedance tomography (EIT) can be used to image changes associated with epileptiform activity and so holds therapeutic potential for improving presurgical localisation of the ictal onset zone in patients treatment-resistant epilepsy. There are two principal which occur during seizures that may imaged EIT: (a) a fast, transient decrease over milliseconds due hypersynchronous neuronal depolarisation individual discharges; (b) larger, slow increase caused by cell swelling course...
Electrical impedance tomography (EIT) can be used to image changes which arise due fast electrical activity during neuronal depolarisation and so holds therapeutic potential for improving the localisation of epileptic seizure foci in patients with treatment-resistant epilepsy aid surgical resection epileptogenic tissue. Prolonged cortical stimulation may, however, induce neural injury through excitotoxicity electrochemical reactions at tissue-electrode interface. The purpose this work was...