A5022585851- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Retinal Development and Disorders
- Receptor Mechanisms and Signaling
- Breastfeeding Practices and Influences
- Neural dynamics and brain function
- Neuroscience and Neural Engineering
- Cognitive Abilities and Testing
- Photoreceptor and optogenetics research
- Neuroethics, Human Enhancement, Biomedical Innovations
- Genetics and Neurodevelopmental Disorders
- Forensic Toxicology and Drug Analysis
- Birth, Development, and Health
- Crime Patterns and Interventions
- Anthropological Studies and Insights
- Aging, Health, and Disability
- Neuroinflammation and Neurodegeneration Mechanisms
- LGBTQ Health, Identity, and Policy
- Sleep and Wakefulness Research
- Cannabis and Cannabinoid Research
- Circadian rhythm and melatonin
- Digital Storytelling and Education
- Food Security and Health in Diverse Populations
- Neuropeptides and Animal Physiology
- Neuroscience of respiration and sleep
Lehigh University
2019-2024
University of California, Los Angeles
2007-2018
New York University
2013-2018
Gènes, synapses et cognition
2012
Institut Pasteur
2012
Centre National de la Recherche Scientifique
2012
Walton Institute for Information and Communications Systems Science
1992
St. Anthony’s Hospital
1985
Significance The hypothalamic orexin (hypocretin) system controls survival-related processes such as food intake, arousal, and stress. Here we show that orexins also play an important role in learning about stimuli predict harm. We demonstrate blocking activity the noradrenergic locus coeruelus (LC) reduces, whereas increasing its enhances, threat a Pavlovian auditory conditioning paradigm. Moreover, direct functional connection between enhancement of LC amygdala-dependent memory processes....
The membrane‐associated guanylate kinases (MAGUKs) PSD‐95, PSD‐93 and SAP102 are thought to have crucial roles in both AMPA receptor trafficking formation of NMDA receptor‐associated signalling complexes involved synaptic plasticity. While PSD‐93, appear similar trafficking, it is not known whether these MAGUKs also functionally To explore this issue we examined several properties basal transmission the hippocampal CA1 region PSD‐95 mutant mice compared ability a number different stimulation...
Understanding the mechanisms whereby information encoded within patterns of action potentials is deciphered by neurons central to cognitive psychology. The multiprotein complexes formed NMDA receptors linked synaptic membrane-associated guanylate kinase (MAGUK) proteins including synapse-associated protein 102 (SAP102) and other associated are instrumental in these processes. Although humans with mutations SAP102 show mental retardation, physiological biochemical involved unknown. Using...
Activity-dependent insertion of AMPA-type glutamate receptors is thought to underlie long-term potentiation (LTP) at Schaffer collateral fiber synapses on pyramidal cells in the hippocampal CA1 region. Although it widely accepted that AMPA these contain receptor type 2 (GluR2) subunits, recent findings suggest LTP slices obtained from 2- 3-wk-old rodents dependent transient postsynaptic and activation Ca(2+)-permeable, GluR2-lacking receptors. Here we examined whether prepared adult animals...
Lesbian, gay, bisexual, transgender, queer, and additional marginalized genders sexualities LGBTQ+ campus resource centers provide essential services for college university communities are increasingly necessary in light of the ongoing reverberating impacts COVID-19 pandemic This commentary describes specific needs student populations accessing health care, psychosocial support, advocacy, academic support context We briefly review current literature suggesting a disproportionate effect on...
Serotonin (5-HT) mediates learning-related facilitation of sensorimotor synapses in Aplysia californica . Under some circumstances 5-HT-dependent requires the activity protein kinase C (PKC). One critical site PKC's contribution to synaptic is presynaptic sensory neuron. Here, we provide evidence that postsynaptic PKC also contributes facilitation. We investigated enhancement glutamate-evoked potential (Glu-EP) isolated siphon motor neurons cell culture. A 10 min application either 5-HT or...
Minimally invasive measurements of neuronal activity are essential for understanding how signal processing is performed by networks. While optical strategies making such hold great promise, sensors generally lack the speed and sensitivity necessary to record on a single-trial, single-neuron basis. Here we present additional biophysical characterization practical improvements two-component voltage sensor (2cVoS), comprised tracer dye, DiO, dipicrylamine (DiO/DPA). Using laser spot...
This final commentary, in comic format, frames this special issue using Graphic Medicine methodologies to explore broader themes and meanings related the scientific study of gender health. Comics can be seen as a way introduce complex human narratives an exploratory tool ask social-contextual ethical questions about health medicine. piece is also constructed through lens queer scholarship, which, together with comics provides opportunities build more embodied, complicated gender, sexuality...
Although plasticity at excitatory synapses is widely studied as a mechanism for memory formation, less known about the properties and mechanisms underlying activity-dependent changes in excitability. Using extracellular intracellular recordings hippocampal slices, we find that short trains (2–3 s) of Schaffer collateral fiber stimulation delivered 5 Hz induce robust persistent increase excitability CA1 pyramidal cells absence synaptic potentiation. This change input specific, NMDA receptor...
Although the activation of extrasynaptic GluN2B-containing N-methyl-d-aspartate (NMDA) receptors has been implicated in neurodegenerative diseases, such as Alzheimer’s and Huntington’s disease, their physiological function remains unknown. In this study, we found that GluN2B play a homeostatic role by antagonizing long-term potentiation (LTP) induction under conditions prolonged synaptic stimulation. particular, have previously brief theta-pulse stimulation (5 Hz for 30 s) triggers robust...
Summary The effect of lactation on menstrual cycles, ovulation and conception was studied in a group non-contracepting Amerindian Mopan Mayan women. Anthropological observations relevant events were made over 21-month period. Blood samples assayed to determine the plasma concentrations prolactin, luteinising hormone, follicle stimulating human chorionic gonadotrophin, placental lactogen, oestrogen, progesterone cortisol. data show that: frequent prolonged breast-feeding associated with...
Noradrenergic signaling in the amygdala is important for processing threats and other emotionally salient stimuli, β-adrenergic receptor activation known to enhance neuronal spiking lateral (LA) of juvenile animals. Nevertheless, intracellular recordings have not yet been conducted determine effect on spike properties adult LA, despite potential significance developmental changes between adolescence adulthood. Here we demonstrate that agonist isoproterenol (15 μM) enhances frequency dorsal...
The existence of recurrent excitatory synapses between pyramidal cells in the hippocampal CA1 region has been known for some time yet little is about activity-dependent forms plasticity at these synapses. Here we demonstrate that under certain experimental conditions, Schaffer collateral/commissural fiber stimulation can elicit robust polysynaptic postsynaptic potentials due to synaptic inputs onto cells. In contrast CA3 cell inputs, exhibited paired-pulse depression and a sustained, but...
Frantz Fanon practiced psychiatry in a colonized Algeria during its struggle for independence. In his 1961 work The Wretched of the Earth, described cases from treatment Algerian nationalists and French colonists. I present one Fanon's as an ethical inquiry into posttraumatic stress disorder (PTSD). A police inspector, who is employed torture, visits with symptoms PTSD after escalating domestic violence. patient asks "to help him torture … total peace mind." Is it possible to treat inspector...
Milk, Money, and Madness: The Culture Politics of Breastfeeding. NAOMI BAUMSLAG DIA L. MICHELS. Westport, CT: Bergin & Garvey, 1995. xxxil + 256 pp., figures, tables, appendixes, references, index.
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