A5086084933- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Memory and Neural Mechanisms
- Alzheimer's disease research and treatments
- Ion channel regulation and function
- Photoreceptor and optogenetics research
- Neural dynamics and brain function
- Helicobacter pylori-related gastroenterology studies
- Neurogenesis and neuroplasticity mechanisms
- Regulation of Appetite and Obesity
- Veterinary medicine and infectious diseases
- Retinal Development and Disorders
- Biochemical Analysis and Sensing Techniques
- Galectins and Cancer Biology
- Genetics and Neurodevelopmental Disorders
- Functional Brain Connectivity Studies
- Molecular Sensors and Ion Detection
- Neuroscience and Neural Engineering
- Nerve injury and regeneration
- Cambodian History and Society
- melanin and skin pigmentation
- Phosphodiesterase function and regulation
- Nitric Oxide and Endothelin Effects
- Bacterial Genetics and Biotechnology
- Dementia and Cognitive Impairment Research
UK Dementia Research Institute
2022-2025
University of Edinburgh
2022-2025
Park Centre for Mental Health
2022-2023
The University of Queensland
2022-2023
Queens University
2022
Institut Interdisciplinaire de Neuroscience
2011-2021
Centre National de la Recherche Scientifique
2010-2021
Université de Bordeaux
2010-2021
University of California, Los Angeles
2001-2018
Toxicologie, Pharmacologie et Signalisation Cellulaire
2010
We have investigated the impact of neuromuscular activity on expression neurotrophins in lumbar spinal cord region and innervating skeletal muscle adult rats. Rats were exercised a treadmill for 1 day or 5 consecutive days euthanized at 0, 2 6 h after last bout exercise. By Day 1, there was no clear evidence an increase brain-derived neurotrophic factor (BDNF) mRNA soleus muscle. 5, significant BDNF post-training, showed robust between 0 post-training. Immunoassays increases protein by...
Inhibitors of both phosphatidylinositol-3-kinase (PI3-kinase) and MAPK/ERK (mitogen-activate protein kinase/extracellular signal-related kinase) activation inhibit NMDA receptor-dependent long-term potentiation (LTP). PI3-kinase inhibitors also block ERK by receptor stimulation, suggesting that LTP because is an essential upstream regulator activation. To examine this hypothesis, we investigated the effects on induction in CA1 region mouse hippocampal slices. Consistent with notion...
Understanding the mechanisms whereby information encoded within patterns of action potentials is deciphered by neurons central to cognitive psychology. The multiprotein complexes formed NMDA receptors linked synaptic membrane-associated guanylate kinase (MAGUK) proteins including synapse-associated protein 102 (SAP102) and other associated are instrumental in these processes. Although humans with mutations SAP102 show mental retardation, physiological biochemical involved unknown. Using...
Alzheimer's disease (AD) is emerging as a synaptopathology driven by metaplasticity. Indeed, reminiscent of metaplasticity, oligomeric forms the amyloid-β peptide (oAβ) prevent induction long-term potentiation (LTP) via prior activation GluN2B-containing NMDA receptors (NMDARs). However, downstream Ca2+-dependent signaling molecules that mediate aberrant metaplasticity are unknown. In this study, we show oAβ promotes Ca2+/calmodulin-dependent kinase II (CaMKII) NMDARs. Importantly, find...
Blocking the constitutive activity of ghrelin receptor impairs spatial and recognition memory.
Memory consolidation after learning involves spontaneous, brain-wide network reorganization during rest and sleep, but how this is achieved still poorly understood. Current theory suggests that the hippocampus pivotal for reshaping of connectivity. Using fMRI in male mice, we identify a different set spontaneous networks their hubs are instrumental consolidating memory post-learning rest. We found two types spatial training invoke distinct functional connections, sensory cortex subcortical...
ABSTRACT Erwinia chrysanthemi exports degradative enzymes by using a type I protein secretion system. The proteases secreted this system lack an N-terminal signal peptide but contain C-terminal signal. To explore the substrate specificity of system, we have expressed E. transporter ( prtDEF genes) in Escherichia coli and tested ability ABC to export hybrid proteins carrying fragments protease B. C terminus contains six glycine-rich repeated motifs, followed two repeats sequences DFLV DIIV....
Although the activation of extrasynaptic GluN2B-containing N-methyl-d-aspartate (NMDA) receptors has been implicated in neurodegenerative diseases, such as Alzheimer’s and Huntington’s disease, their physiological function remains unknown. In this study, we found that GluN2B play a homeostatic role by antagonizing long-term potentiation (LTP) induction under conditions prolonged synaptic stimulation. particular, have previously brief theta-pulse stimulation (5 Hz for 30 s) triggers robust...
This scientific commentary refers to ‘Alteration of functional connectivity network in population objectively-defined subtle cognitive decline’ by Zhang et al. (https://doi.org/10.1093/braincomms/fcae033) and ‘Posterior cingulate cortex reveals an expression profile resilience cognitively intact elders’ Kelley (https://doi.org/10.1093/braincomms/fcac162) Brain Communications ‘Determinants brain tau pathology: a longitudinal analysis’ Bocancea (https://doi.org/10.1093/brain/awad100)
We have previously cloned 10 Helicobacter pylori antigen genes from a Chilean strain including: cytotoxin VacA, truncated region of CagA (called A17), species‐specific protein (Ag26), urease subunits (UreA, UreB), flagellin, (FlaB), heat shock proteins (HspA and HspB), an adhesin (HpaA) lipoprotein (Lpp20). Immunogenicity these antigens was tested by immunoblot with sera infected patients, revealing that HpaA, A17, HspB VacA were more frequently recognized (86%, 82%, 68% 68%, respectively)....
We have cloned and sequenced ten Helicobacter pylori genes from a Chilean strain (CH-CTX1) including: cytotoxin VacA fragment, CagA fragment (A17), species-specific protein (TsaA), urease subunits (UreA, UreB), flagellin subunit (FlaB), heat shock proteins (HspA HspB), adhesin (HpaA) lipoprotein (Lpp20). compared their deduced amino acid sequences with the corresponding three unrelated H. strains, including fully strains 26695(UK) J99(USA), found that eight of them UreB, FlaB, HspA, HspB,...
Abstract Brain stores new information by modifying connections between neurons. When is learnt, a group of neurons gets activated and they are connected to each other via synapses. Dendritic spines protrusions along neuronal dendrites where excitatory synapses located. the first structures protrude out from dendrite reach establish connection. Thus, it expected that activity enhances spine initiation. However, molecular mechanisms linking initiation poorly known. Membrane binding BAR domain...
SUMMARY Memory consolidation after learning involves spontaneous, brain-wide network reorganization during rest and sleep, but how this is achieved still poorly understood. Current theory suggests that the hippocampus pivotal for reshaping connectivity. Here we identify a different set of spontaneous networks their hubs are instrumental in consolidating memory post-learning rest. We found two types spatial training invoke distinct functional connections, sensory cortex subcortical areas...
Abstract The ability of animals to store and retrieve food caches in the wild requires integration biological signals hunger, satiety memory. role ghrelin regulating feeding memory makes receptors an important target shape required cellular molecular responses. We investigated effects high ligand-independent activity receptor on physiology excitatory synapses. Blocking this type produced a decrease synaptic content AMPA hippocampal neurons reduction GluA1 phosphorylation at Ser845. Impaired...