A5077824291- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Nicotinic Acetylcholine Receptors Study
- Receptor Mechanisms and Signaling
- Cellular transport and secretion
- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Memory and Neural Mechanisms
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Lipid Membrane Structure and Behavior
- Genetics and Neurodevelopmental Disorders
- Neurogenesis and neuroplasticity mechanisms
- Neurobiology and Insect Physiology Research
- Neuroscience and Neural Engineering
- Mitochondrial Function and Pathology
- Retinal Development and Disorders
- Molecular Sensors and Ion Detection
- Epilepsy research and treatment
- Cannabis and Cannabinoid Research
- Sleep and Wakefulness Research
- Neurotransmitter Receptor Influence on Behavior
- RNA Interference and Gene Delivery
- Biochemical Analysis and Sensing Techniques
- Neurological disorders and treatments
Centre National de la Recherche Scientifique
2016-2025
Institut Interdisciplinaire de Neuroscience
2016-2025
Université de Bordeaux
2016-2025
Inserm
2021
Bordeaux Imaging Center
2021
University of Copenhagen
2017
University of Liège
2017
University of Milan
2015
Neurocentre Magendie
2000-2012
Fondazione Umberto Di Mario
2010
The effects of depriving thalamic relay and intralaminar nuclei from their reticularis thalami (RE) inputs were investigated in acute chronic experiments on cat. In acutely prepared animals, two (frontal parasagittal) transections made; extracellular intracellular recordings performed RE-disconnected nuclei. experiments, the RE nuclear complex was lesioned by means kainic acid injections; activity RE-deprived thalamocortical neurons extracellularly studied during wakefulness synchronized...
Abstract Synaptic plasticity in the autoassociative network of recurrent connections among hippocampal CA3 pyramidal cells is thought to enable storage episodic memory. Impaired memory an early manifestation cognitive deficits Alzheimer’s disease (AD). In APP/PS1 mouse model AD amyloidosis, we show that associative long-term synaptic potentiation (LTP) abolished at stage. This caused by activation upregulated neuronal adenosine A 2A receptors (A R) rather than dysregulation NMDAR signalling...
Presynaptic nicotinic ACh receptors (nAChRs) are abundant in the nervous system, where they thought to regulate release of various neurotransmitters. Whole-cell recordings performed on rat interpeduncular nucleus neurons using thin-slice technique showed that nicotine dramatically increased frequency postsynaptic GABAergic currents. This effect was observed at low micromolar concentration agonist; it mimicked by cytisine, dimethylphenylpiperazinium, and presence eserine. It blocked...
The putative channel-forming MII domains of the nicotinic, gamma-aminobutyric acid type A, and glycine receptors contain a highly conserved leucine residue. Mutation this hydrophobic amino in neuronal nicotinic receptor alpha 7 (Leu-247), reconstituted Xenopus oocytes, modifies ionic response to acetylcholine alters desensitization. Furthermore, Leu----Thr (L247T) mutant has two conducting states (46 pS 80 pS), contrast with wild-type (WT) receptor, which only one (45 pS). We now show that...
Reticularis thalami neurons (RE neurons) were identified morphologically, and their electrophysiological properties studied in cat under barbiturate anesthesia. Intracellular HRP injections showed that RE possessed very long dendrites bearing numerous filopodia-like appendages axons directed toward main thalamic nuclei. As a rule, small axonal branches also emitted within the nucleus itself. At rest, membrane potential of displayed 2 types oscillations: slow 0.1–0.2 Hz oscillation fast 7–12...
Kainate receptors are abundantly expressed in the hippocampus. Mice with disruption of kainate receptor subunits allow genetic dissection role each synaptic physiology hippocampus, as well excitotoxic processes. We have compared action domoate and on CA1 pyramidal neurons slices from wild-type GluR6−/− mice. The difference amplitude inward currents evoked by between mice demonstrates presence functional neurons. Block domoate-activated AMPA antagonists...
Calcitonin gene-related peptide (CGRP) is a neuropeptide that coexists with acetylcholine in spinal cord motoneurons. The effects of CGRP on the functional properties nicotinic receptor (AcChoR) were examined by electrophysiological methods. Using whole-cell patch-clamp technique and mouse cell line derived from soleus muscle, we found produces progressive reversible enhancement rapid-decay phase AcChoR desensitization. Single-channel data further show decreases acetylcholine-activated...
Neuronal nicotinic ACh receptors (nAChRs) are present in the rat medial habenula (MHB) and interpeduncular nucleus (IPN), two brain regions connected through fasciculus retroflexus (FR). The goal of study was to compare electrophysiological pharmacological characteristics nAChRs located at pre- postsynaptic sites within MHB-IPN system. on soma IPN neurons were studied using patch-clamp techniques a preparation acutely isolated neurons. Whole-cell currents evoked by Ach nicotine showed an...