Over the last several decades, fast-scan cyclic voltammetry (FSCV) has proved to be a valuable analytical tool for real-time measurement of neurotransmitter dynamics in vitro and vivo. Indeed, FSCV found application wide variety disciplines including electrochemistry, neurobiology, behavioral psychology. The maturation as an vivo technique led users pose increasingly complex questions that require more sophisticated experimental design. To accommodate recent future advances application, our...

Abstract Objective To determine the degree of agreement between prenatal ultrasound diagnosis brain abnormalities and subsequent pathologic findings. Methods Between August 1993 1999 there were 62 cases where a fetus with abnormality other than neural tube defects underwent autopsy at Regional Department Pediatric Pathology. The cerebral was compared findings in all cases. Results In 47 61 (77%) same seen on autopsy. most common disparity Dandy–Walker malformation or variant, only six 14...

To examine the genital tract flora in women with preterm prelabour rupture of membranes and to determine relationship these microorganisms those found fetal blood amniotic fluid.Prospective study 97 patients membranes.Maternal-fetal medicine centre.High vaginal endocervical swabs were taken for routine culture aerobic anaerobic bacteria Ureaplasma urealyticum Mycoplasma hominis. Cordocentesis amniocentesis performed fluid cultured bacteria. Amniotic was also spp. The sensitivities...

Baseline morning and evening serum cortisol ACTH concentrations, diurnal changes in hormone levels, were measured 30 patients with chronic fatigue syndrome (CFS) but without concurrent depressive disorder a control group of 15 weight-, age- sex-matched healthy volunteers. Morning levels non-significantly lower CFS patients, while higher. concentrations higher both the evening. The change was significantly less than controls (p < 0.05). In subjects, correlated measures general health...

The brain is thought to exert a predominantly stimulatory action on ACTH secretion mediated mainly by corticotrophin-releasing factor-41 (CRF-41) and arginine vasopressin (AVP). Several data, however, also point the existence of an ACTH-inhibiting factor. Atrial natriuretic peptide (ANP), at concentrations found in hypophysial portal blood, inhibits release vitro. aim present studies was use ANP immunoneutralization determine whether does fact inhibit vivo. Intracerebroventricular infusion...

Selective serotonin reuptake inhibitors (SSRIs) were designed to treat depression by increasing levels throughout the brain via inhibition of clearance from extracellular space. Although increases in are observed after acute SSRI exposure, 3-6 weeks continuous use is required for relief symptoms depression. Thus, it now believed that plasticity multiple systems downstream serotonergic inputs contributes therapeutic efficacy SSRIs. The onset antidepressant effects also coincides with...

This study aimed to determine if fetal bacteraemia and amniotic fluid infection at the time of membrane rupture reduces interval between onset labour in pregnancies complicated by preterm prelabour amniorrhexis. Sixty nine with amniorrhexis 12-36 weeks9 gestation that were managed expectantly had spontaneous labour. In all cases cordocentesis amniocentesis performed blood cultured for aerobic anaerobic bacteria. group negative cultures (group 1) median from delivery was 41 days (range 1-161)...

Background:Poor dual-task gait (walking while performing a cognitively demanding task) has been linked to progression dementia in older adults with mild cognitive impairment (MCI). However, many of these findings come from research environments; performance across the spectrum not previously studied clinical setting. Objective:To examine whether patients memory clinic show differences usual and speed cost (DTC) based on diagnosis. Methods:Patients Aging Brain Memory Clinic (London, ON)...

Background Spontaneous spinal hematomas are rare in pregnancy, and only two cases have previously been described. This report reviews other similar discusses the aetiology management of this condition relation to pregnancy. Purpose A 26-year-old primigravida presented at 35 weeks gestation with a history sudden onset back pain weakness loss sensation her legs. On examination there was tenderness over seventh thoracic vertebra below level T7 dermatome reduced power both lower limbs. Magnetic...

This is an overview of current trends in online illicit crypto-markets or dark-nets, including the key role virtual crypto-currencies their operation. The focus on different kinds digital products that are found these on-line 'dark markets'. Primary data was collected from relevant websites accessed via Onion Router (Tor). Tor allows anonymous encrypted communication between web-sites, and capture over several months one largest currently active - Dream Market enabled a description...

Objective Improving Access to Psychological Therapies (IAPT) services in England have established a long‐term condition (LTC) pathway recent years, meaning that LTC therapies are now delivered via varied modes and by professionals with experiences. To gain insight into how this new is functioning practice, study aimed explore therapists’ perceptions of barriers facilitators uptake engagement therapy LTCs. Design A qualitative design was employed using semi‐structured interviews. Methods...

The aim of this study was to assess the value middle cerebral artery (MCA) Doppler time-averaged mean velocity (TAMV) for prediction fetal anaemia in at-risk cases without ultrasound evidence hydrops. included 35 pregnant women with non-hydropic fetuses and known red cell antibodies, referred either because a rapid increase antibody levels or previous history severely anaemic fetus neonate. After full examination fetus, MCA TAMV measured and, if severe suspected, blood sampling by...

ABSTRACT The role of atrial natriuretic peptide (ANP) in the ACTH response to stress and glucocorticoid negative feedback control release was investigated adult male homozygous Brattleboro adrenalectomized Wistar rats respectively, using technique immunoneutralization. relatively low lack arginine vasopressin make rat a more rigorous simpler preparation which test hypothesis that ANP is involved stress. In both sets experiments, blood sampling injection sheep anti-ANP or serum were carried...

SYNOPSIS The secretion of prolactin and growth hormone (GH), together with subjective ratings sedation hunger, were determined in 13 in-patients anorexia nervosa 15 controls during the intravenous infusion L-tryptophan (100 mg/kg). Prolactin responses not different between groups but GH markedly blunted patients. In addition patients attenuated compared controls. Hunger reduced by too variable to be interpreted Plasma amino acid levels also before after L-tryptophan. Tryptophan comparable...

Abstract. We have assessed fetal and maternal nitric oxide (NO) production in pregnancy. Exhaled NO amniotic fluid nitrite concentrations were measured by chemiluminescence between 10 42 weeks of did not alter significantly during gestation. In contrast, there was a significant change mean concentration late pregnancy ( P < 0.001). The finding decreased after 37 gestation support the hypothesis that reduced may contribute to increased uterine activity