A5042202235- Pregnancy and preeclampsia studies
- Cardiovascular Issues in Pregnancy
- Gestational Diabetes Research and Management
- Maternal and fetal healthcare
- Prenatal Screening and Diagnostics
- Assisted Reproductive Technology and Twin Pregnancy
- Pregnancy and Medication Impact
- Congenital Heart Disease Studies
- Ectopic Pregnancy Diagnosis and Management
- Birth, Development, and Health
- Parathyroid Disorders and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Dermatological and Skeletal Disorders
- Healthcare Systems and Practices
- Hypertrophic osteoarthropathy and related conditions
- Cardiac Arrhythmias and Treatments
- Pediatric Urology and Nephrology Studies
- Congenital Anomalies and Fetal Surgery
- Tumors and Oncological Cases
- Tracheal and airway disorders
- Venous Thromboembolism Diagnosis and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Lipoproteins and Cardiovascular Health
- Child Abuse and Related Trauma
- Parvovirus B19 Infection Studies
National Maternity Hospital
2008-2022
University College Dublin
2008-2021
Objective Evaluate the feasibility and acceptability of routine aspirin in low-risk women, compared with screening-test indicated for prevention pre-eclampsia fetal growth restriction. Design Multicentre open-label randomised controlled trial. Setting Two tertiary maternity hospitals Dublin, Ireland. Participants 546 nulliparous women completed study. Interventions Women underwent computerised randomisation to: Group 1—routine 75 mg from 11 until 36 weeks; 2—no and; 3—aspirin based on Fetal...
The objective was to evaluate whether routine aspirin 75 mg is more cost-effective than the Fetal Medicine Foundation screen-and-treat approach for preeclampsia prevention in low-risk nulliparous women. A health economic decision analytical model devised estimate discounted net and cost outcomes of versus screening test-indicated a cohort 100 000 Both strategies were compared with no intervention. subanalysis also disaggregated components algorithm. analysis used data from hospital...
ABSTRACT Objective To construct monochorionic diamniotic ( MCDA ) and dichorionic DCDA twin reference ranges for umbilical artery UA pulsatility index PI ), resistance RI fetal middle cerebral MCA peak systolic velocity PSV cerebroplacental ratio CPR from 24 weeks' to 38 gestation compare these with published normal values singleton pregnancies. Methods This prospective multicenter cohort study included 1028 unselected pairs recruited over a 2‐year period. Participants twins underwent...
Objective This article evaluates the effect of low-dose aspirin on uterine artery (UtA) Doppler, placental volume, and vascularization flow indices in low-risk pregnancy. Study Design In this secondary analysis TEST randomized controlled trial, nulliparous women were originally at 11 weeks to: (1) routine 75 mg; (2) no aspirin; (3) based upon preeclampsia Fetal Medicine Foundation screening test. UtA three-dimensional (3D) assessed prior to 6 postaspirin commencement. Results A total 546...
Aims Higher rates of fetal macrosomia may occur in infants women with pre-gestational diabetes compared non-diabetic controls. Antenatal predication remains challenging. Ultrasound over-estimated weight could result over-classification fetuses as macrosomic corresponding inappropriate clinical interventions. Previously we had studied a measurement – the anterior abdominal wall (AAW) to predict estimation weight. The purpose study was whether specific third trimester ultrasound measurements...
Idiopathic infantile arterial calcification (IIAC) is a rare autosomal recessive disorder characterised by extensive and proliferation of the intimal layer large medium size arteries. We report 4 antenatal cases IIAC in our institution over 10 year period from 2006 to 2016. Clinical outcomes, prenatal ultrasound findings, radiological postmortem investigations are summarized. A literature review this disease presented. The possible aetiology condition role biphosphonates management...
Objective To assess the effect of aspirin use in low-risk pregnancy on: (1) pregnancy-associated plasma protein-A (PAPP-A) and placental-like growth factor (PLGF); (2) urinary albumin-to-creatinine ratio (ACR) blood pressure; (3) fetal parameters; (4) placental histopathology. Study Design This secondary analysis from T rial low-dose with an E arly S creening est for preeclampsia restriction randomized controlled trial was based on nulliparous women at 11 weeks to 75 mg; no aspirin; Fetal...
IIAC is a rare autosomal recessive disorder characterised by extensive calcification and proliferation of the intimal layer large medium size arteries. We report 4 cases over 10yrs in our centre. Case 1: 21yr old P1. Both aortic (Ao) pulmonary artery (PA) tricuspid valve were noted to be calcified at 20 week scan. The fetus became hydropic fetal demise occurred 29+ weeks. molecular diagnosis was confirmed from cultured amniocytes. 2: 35yr old.G2. CVS results indicated that homozygous carrier...
<h3>Objectives</h3> Pre-eclampsia (PET) and intrauterine growth restriction (IUGR), often associated with impaired placental function, are among the most common conditions contributing to increased perinatal mortality morbidity. This study investigates if three dimensional power Doppler (3DPD) of placenta computerised analysis calcification is different between PET/IUGR normal pregnancies. <h3>Methods</h3> A prospective cohort involving 50 women PET and/or IUGR. Gestational age ranged from...
Supporting information can be found in the online version of this abstract Please note: The publisher is not responsible for content or functionality any supporting supplied by authors. Any queries (other than missing content) should directed to corresponding author article.
<h3>Objective</h3> To compare mode of delivery in fetuses with known congenital heart disease (CHD) versus the background rate non-anomalous fetuses. <h3>Methods</h3> We examined all cases prenatally-diagnosed CHD over 5-year study period, 2007–2011. Data were extracted from computerised patient records. Control data for obtained published hospital records 2007. Categorical analysed using Fisher’s exact test (5% level significant). <h3>Results</h3> identified 242 period. excluded 25 lethal...
<h3>Background</h3> Our unit offers a comprehensive fetal echocardiograhy service to expectant mothers who are at increased risk of having fetus with cardiac defect. <h3>Methods</h3> A prospective study from January 2007 December 2011. Cases echocardiography were extracted and analysed for referral indication, the presence extra-cardiac anomalies on ultrasound and, where applicable, results invasive testing karyotype. Indications classified as abnormal anatomy scan, family history,...