A5057230309- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Peroxisome Proliferator-Activated Receptors
- Neurogenesis and neuroplasticity mechanisms
- Bone and Dental Protein Studies
- Calpain Protease Function and Regulation
- Nerve injury and regeneration
- Immune Response and Inflammation
- Acute Ischemic Stroke Management
- Neurological Disorders and Treatments
- Metabolomics and Mass Spectrometry Studies
- Atherosclerosis and Cardiovascular Diseases
- Immune cells in cancer
- T-cell and B-cell Immunology
- Oral microbiology and periodontitis research
- Bone Metabolism and Diseases
University of Arizona
2018-2024
Stanford University
2021
Southern Arizona VA Health Care System
2021
The goal of this study was to evaluate changes in metabolic homeostasis during the first 12 weeks recovery a distal middle cerebral artery occlusion mouse model stroke. To achieve goal, we compared brain metabolomes ipsilateral and contralateral hemispheres from aged male mice up after stroke that age-matched naïve sham mice. There were 707 biochemicals detected each sample by liquid chromatography-mass spectroscopy (LC-MS). Mitochondrial fatty acid β-oxidation, indicated acyl carnitine...
<h3>Abstract</h3> Here we used mouse models of heart and brain ischemia to compare the inflammatory response in heart, a protein rich organ, brain, lipid organ. We report that ischemia-induced inflammation resolves between one four weeks compared eight 24 brain. Importantly, discovered second burst occurs following ischemia, which coincided with appearance cholesterol crystals within infarct. This wave shares similar cellular molecular profile atherosclerosis is characterized by high levels...
Globally, more than 67 million people are living with the effects of ischemic stroke. Importantly, many stroke survivors develop a chronic inflammatory response that may contribute to cognitive impairment, common and debilitating sequela is insufficiently studied currently untreatable. 2-Hydroxypropyl-β-cyclodextrin (HPβCD) an FDA-approved cyclic oligosaccharide can solubilize entrap lipophilic substances. The goal present study was determine whether repeated administration HPβCD curtails by...
Up to 30% of stroke patients experience cognitive decline within one year their stroke. There are currently no FDA-approved drugs that can prevent post-stroke decline, in part due a poor understanding the mechanisms involved. We have previously demonstrated B-lymphocyte response stroke, marked by IgA + cells, cause delayed dysfunction mice and similar adaptive immune occurs brains some human suffer from vascular dementia. The stimuli which trigger activation following target antigens, still...
Following ischemic stroke, the degradation of myelin and other cellular membranes surpasses lipid-processing capabilities resident microglia infiltrating macrophages. This imbalance leads to foam cell formation in infarct areas secondary neurodegeneration, instigating sustained inflammation furthering neurological damage. Given that mitochondria are primary sites fatty acid metabolism, augmenting mitochondrial biogenesis (MB) may enhance lipid processing, curtailing post-stroke chronic...
The aim of this study was to test whether poststroke oral administration a small molecule p75 neurotrophin receptor (p75<sup>NTR</sup>) modulator (LM11A-31) can augment neuronal survival and improve recovery in mouse model stroke. Mice were administered LM11A-31 for up 12 weeks, beginning 1 week after Metabolomic analysis revealed that 2 weeks daily treatment, mice received distinct from vehicle-treated by principal component had higher levels serotonin, acetylcholine, dopamine their...
Abstract Here we used mouse models of heart and brain ischemia to compare the inflammatory response in heart, a protein rich organ, brain, lipid organ. We report that ischemia-induced inflammation resolves between 1 4 weeks compared 8 24 brain. Importantly, discovered second burst occurs following ischemia, which coincided with appearance cholesterol crystals within infarct. This wave shares similar cellular molecular profile atherosclerosis is characterized by high levels osteopontin (OPN)...
Following ischemic stroke, the degradation of myelin and other cellular membranes surpasses lipid-processing capabilities resident microglia infiltrating macrophages. This imbalance leads to foam cell formation in infarct areas secondary neurodegeneration, instigating sustained inflammation furthering neurological damage. Given that mitochondria are primary sites fatty acid metabolism, augmenting mitochondrial biogenesis (MB) may enhance lipid processing, curtailing post-stroke chronic...
Abstract The goal of this study was to evaluate changes in metabolic homeostasis during the first 12 weeks recovery a distal middle cerebral artery occlusion mouse model stroke. To achieve goal, we compared brain metabolomes ipsilateral and contralateral hemispheres from aged male mice up after stroke that age-matched naïve sham operated mice. There were 707 biochemicals detected each sample by liquid chromatography-mass spectroscopy (LC-MS). Mitochondrial fatty acid β-oxidation, indicated...
Abstract Globally, more than 67 million people are living with the effects of ischemic stroke. Importantly, many stroke survivors develop a chronic inflammatory response that may contribute to cognitive impairment, common and debilitating sequela is insufficiently studied currently untreatable. 2-hydroxypropyl-β-cyclodextrin (HPβCD) an FDA-approved cyclic oligosaccharide can solubilize entrap lipophilic substances. The goal present study was determine whether repeated administration HPβCD...
ABSTRACT The aim of this study was to test whether post-stroke oral administration a small molecule p75 neurotrophin receptor (p75 NTR ) modulator (LM11A-31) can augment neuronal survival and improve recovery in mouse model stroke. Mice were administered LM11A-31 for up 12 weeks, beginning 1 week after Metabolomic analysis revealed that 2 weeks daily treatment, mice received distinct from vehicle treated by principal component had higher levels serotonin, acetylcholine, dopamine their...