A5090486036- Cancer Mechanisms and Therapy
- FOXO transcription factor regulation
- Endometrial and Cervical Cancer Treatments
- Cervical Cancer and HPV Research
- Colorectal and Anal Carcinomas
- Advanced Radiotherapy Techniques
- Cancer Cells and Metastasis
- Ubiquitin and proteasome pathways
- TGF-β signaling in diseases
- Genomics and Chromatin Dynamics
- Molecular Biology Techniques and Applications
- Cancer therapeutics and mechanisms
- Circular RNAs in diseases
- Gene expression and cancer classification
- Beetle Biology and Toxicology Studies
- MicroRNA in disease regulation
Xinjiang Medical University
2009-2024
Tumor Hospital of Xinjiang Medical University
2009-2022
Central South University
2017
Xiangya Hospital Central South University
2017
Abstract Paclitaxel is clinically used as a first-line chemotherapeutic regimen for several cancer types, including head and neck cancers. However, acquired drug resistance results in the failure of therapy, metastasis relapse. The efflux mediated by ATP-binding cassette (ABC) transporters survival signals activated forkhead box (FOX) molecules are critical development paclitaxel resistance. Whether FOX promote through remains unknown. In this study, we developed types paclitaxel-resistant...
The aim of the present study was to investigate effect forkhead box M1 (FOXM1) paclitaxel resistance in cervical cancer cells, determine underlying mechanism, and identify novel targets for treatment paclitaxel-resistant cancer.Paclitaxel-resistant Caski cells (Caski/Taxol cells) were established by intermittently exposing gradually increasing concentrations paclitaxel. association between FOXM1, ATP-binding cassette subfamily C member 5 (ABCC5), cell drug assessed overexpressing or knocking...
Previous studies suggest that SRPK1 (serine/arginine-rich protein-specific kinase 1) is involved in tumorigenesis and closely related to unfavorable outcomes. However, its expression pattern cervical squamous cell carcinoma (CESC) remains uncovered. In this study, we initially investigated the clinical significance function of human CESC. Data mining analysis on mRNA CESC samples were conducted using TCGA database, which indicated was significantly upregulated samples. Protein tested by...
Abstract This study analyses 1000 cases of patients with breast cancer and 2000 gynecological (1000 malignant tumor, benign tumors), where tumor comprise the observation group, while tumors control group. Through DNA extraction, STR genotyping variation verification, microdissection, individual mutation rate loci two groups were calculated. Results show that there are no significant (P > 0.05) differences in autosomes X chromosome between group those reference However, < intergroup...
Abstract Radiotherapy (RT) is a conventional cancer therapeutic modality. However, cells tend to develop radioresistance after period of treatment. Diagnostic markers and targets for radiosensitivity are severely lacking. Our recently published studies demonstrated that the cell division cycle (CDC6) critical molecule contributing radioresistance, maybe potential target overcome radioresistance. In present study, we first time reported Norcantharidin (NCTD), demethylated form cantharidin,...
To determine the vaginal flora distribution in cervical cancer patients and common pathogenic bacteria as well drug resistance, to explore correlation of bacterial infection high-risk human papillomavirus (HR-HPV) with cancer. A total 216 served an experimental group, 53 chronic cervicitis a control group. The patients' fluid two groups was collected before treatment for regular culture HPV testing. resistance secretion were observed, analyzed. gram-negative gram-positive accounted 74.38%...
Objective To evaluate the efficacy of intensity modulated radiotherapy in early stage cervical cancer with vaginal stump recurrence after surgery.Methods A retrospective concurrent comparative study included 60 patients surgery cancer.30 cases experimental group were treated intensity-modulated (IMRT),and 30 control conventional radiotherapy.The and complications between two groups compared 3 treatment cycles.Results Of group,22 achieved complete remission,7 had partial 1 progressed.But...
Objective To compare the dose distribution of mantle-field radiotherapy using conven-tional radiotherapy(CRT) and four intensity-modulated radiotherapy(IMRT) techniques in stage Ⅰ Ⅱ Hodgkin's lymphoma(HL). Methods Ten patients with patholocally proved early HL underwent CT simulation. Then both CRT IMRT planning performed ECLIPS treatment system(TPS). The dosimetric parameters different irradiation plans were analyzed, including conformal index (CI), homo-geneity (HI), D_(95) V_(95) target...