A5067299714- Eicosanoids and Hypertension Pharmacology
- Cancer, Stress, Anesthesia, and Immune Response
- Bacterial Genetics and Biotechnology
- Inflammation biomarkers and pathways
- Cancer, Lipids, and Metabolism
- Acute Myeloid Leukemia Research
- Epigenetics and DNA Methylation
- Immune Response and Inflammation
- Enzyme Structure and Function
- Cancer, Hypoxia, and Metabolism
- Immune cells in cancer
- DNA Repair Mechanisms
- Fungal and yeast genetics research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Amino Acid Enzymes and Metabolism
- Vector-Borne Animal Diseases
- Microbial Metabolic Engineering and Bioproduction
- Peroxisome Proliferator-Activated Receptors
- Renal and related cancers
- S100 Proteins and Annexins
- interferon and immune responses
- Retinoids in leukemia and cellular processes
- Renal cell carcinoma treatment
- Galectins and Cancer Biology
- RNA Research and Splicing
Albert Einstein College of Medicine
2019-2024
Montefiore Medical Center
2020-2024
Indian Institute of Technology Delhi
2022
Cancer Institute (WIA)
2022
Mutations in the SF3B1 splicing factor are commonly seen myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), yet specific oncogenic pathways activated by mis-splicing have not been fully elucidated. Inflammatory immune shown to play roles pathogenesis of MDS, though exact mechanisms their activation mutant cases well understood.RNA-seq data from samples was analyzed functional interleukin-1 receptor-associated kinase 4 (IRAK4) isoforms were determined. Efficacy IRAK4 inhibition...
Significance This study demonstrates that underexpression of succinate dehydrogenase (SDH) subunits resulting in accumulation oncogenic is a common, adverse, epigenetic modulating feature clear cell renal carcinoma (ccRCC), during pathogenesis and progression. The sheds light on the mechanisms down-regulation SDH ccRCC deciphers consequent effects. It shows functional deficiency common (∼80% all kidney cancers), not just limited to 0.05 0.5% cancers with germline mutations.
<div>AbstractPurpose:<p>Even though smoking is associated with lung cancer, the exact molecular pathways that link carcinogens inflammation and oncogenic transformation are not well elucidated. Two major in cigarette smoke, nicotine-derived nitrosamine ketone, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), benzo(α)pyrene (BaP), have been tested models mimic inhaled exposure for prolonged periods of time.</p>Experimental Design:<p>Mouse were used intratracheal...
<p>Supplementary Figure S6. Downregulated phosphorylations after IRAK4 inhibitor treatment.</p>
<p>Supplementary Figure S5. Annotated MS/MS spectrum of the phosphopeptide MYH9 modified with serine 1943 phosphorylation. Red and blue lines indicate matches between observed expected fragment masses (red is b series, while y series). Fragments annotated as “-Phos” that phosphorylation fragmented out peptide leaving a diagnostic mass -96 Da.</p>
<p>Supplementary Figure S1. Uncropped Western Blots for 4C data presented in the manuscript. Also see Data Availability Statement.</p>
<p>Supplementary Figure S3. Exposure to carcinogens leads carcinogenesis in murine lungs: Representative histological examples of mouse lung observed during the study assess effect smoking carcinogens.</p>
<p>Supplementary Figure S2. Uncropped Western Blots for 6A data presented in the manuscript. Also see Data Availability Statement.</p>
<p>Supplementary Figure S4. Immunofluorescence using CD68 Cy5 on mouse lung tissues harvested after 18 months of intratracheal treatment. Magenta stain represent antibody and blue nuclear counterstain DAPI. Left, representative image for PBS administration. Right, mice administered NB (NNK BaP).</p>
<p>Supplementary Figure S6. Downregulated phosphorylations after IRAK4 inhibitor treatment.</p>
<p>Supplementary Figure S3. Exposure to carcinogens leads carcinogenesis in murine lungs: Representative histological examples of mouse lung observed during the study assess effect smoking carcinogens.</p>
<p>Supplementary Figure S1. Uncropped Western Blots for 4C data presented in the manuscript. Also see Data Availability Statement.</p>
<p>Supplementary Figure S4. Immunofluorescence using CD68 Cy5 on mouse lung tissues harvested after 18 months of intratracheal treatment. Magenta stain represent antibody and blue nuclear counterstain DAPI. Left, representative image for PBS administration. Right, mice administered NB (NNK BaP).</p>