A5038159820- Eicosanoids and Hypertension Pharmacology
- Cancer, Stress, Anesthesia, and Immune Response
- Cytomegalovirus and herpesvirus research
- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- Venous Thromboembolism Diagnosis and Management
- Acute Myeloid Leukemia Research
- Inflammation biomarkers and pathways
- Hematopoietic Stem Cell Transplantation
- Cancer, Lipids, and Metabolism
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diabetes and associated disorders
- Mycobacterium research and diagnosis
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Genomics and Diagnostics
- Vascular Malformations and Hemangiomas
- CAR-T cell therapy research
- Cardiac tumors and thrombi
- Neonatal Health and Biochemistry
- Biosimilars and Bioanalytical Methods
- Otolaryngology and Infectious Diseases
- Neurological Complications and Syndromes
- Ear Surgery and Otitis Media
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer-related gene regulation
Johns Hopkins University
2023-2024
Sidney Kimmel Comprehensive Cancer Center
2023-2024
Memorial Sloan Kettering Cancer Center
2019-2022
Jacobi Medical Center
2020-2022
University of Crete
2022
Albert Einstein College of Medicine
2020-2021
General Hospital of Athens G. Genimatas
2020
Montefiore Medical Center
2020
National and Kapodistrian University of Athens
2017-2019
Abstract Background Cytomegalovirus (CMV)–seropositive (R+) hematopoietic cell transplant (HCT) recipients have a survival disparity compared with CMV-seronegative recipient/donor (R–D–) pairs. We hypothesized that primary letermovir prophylaxis (LET) may abrogate this disparity. investigated the relationship between LET and mortality at 1 year post-HCT. Methods In retrospective cohort study, we included adult R–D– or R+ patients who received HCT pre-LET (between January 2013 through 15...
(Val)ganciclovir (vGCV) or foscarnet (FCN) as preemptive therapy (PET) for cytomegalovirus (CMV) after allogeneic hematopoietic cell transplantation (HCT) is associated with myelosuppression and nephrotoxicity, respectively. We analyzed a cohort of CMV-seropositive (R+) HCT recipients managed preemptively at single center. The objectives our study were to (1) quantify the frequencies neutropenia acute kidney injury (AKI) through day +100 (D100) post-HCT PET discontinuation (2) assess impact...
<div>AbstractPurpose:<p>Even though smoking is associated with lung cancer, the exact molecular pathways that link carcinogens inflammation and oncogenic transformation are not well elucidated. Two major in cigarette smoke, nicotine-derived nitrosamine ketone, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), benzo(α)pyrene (BaP), have been tested models mimic inhaled exposure for prolonged periods of time.</p>Experimental Design:<p>Mouse were used intratracheal...
<p>Supplementary Figure S6. Downregulated phosphorylations after IRAK4 inhibitor treatment.</p>
<p>Supplementary Figure S5. Annotated MS/MS spectrum of the phosphopeptide MYH9 modified with serine 1943 phosphorylation. Red and blue lines indicate matches between observed expected fragment masses (red is b series, while y series). Fragments annotated as “-Phos” that phosphorylation fragmented out peptide leaving a diagnostic mass -96 Da.</p>
<p>Supplementary Figure S1. Uncropped Western Blots for 4C data presented in the manuscript. Also see Data Availability Statement.</p>
<p>Supplementary Figure S3. Exposure to carcinogens leads carcinogenesis in murine lungs: Representative histological examples of mouse lung observed during the study assess effect smoking carcinogens.</p>
<p>Supplementary Figure S2. Uncropped Western Blots for 6A data presented in the manuscript. Also see Data Availability Statement.</p>
<p>Supplementary Figure S4. Immunofluorescence using CD68 Cy5 on mouse lung tissues harvested after 18 months of intratracheal treatment. Magenta stain represent antibody and blue nuclear counterstain DAPI. Left, representative image for PBS administration. Right, mice administered NB (NNK BaP).</p>
<p>Supplementary Figure S6. Downregulated phosphorylations after IRAK4 inhibitor treatment.</p>
<p>Supplementary Figure S3. Exposure to carcinogens leads carcinogenesis in murine lungs: Representative histological examples of mouse lung observed during the study assess effect smoking carcinogens.</p>
<p>Supplementary Figure S1. Uncropped Western Blots for 4C data presented in the manuscript. Also see Data Availability Statement.</p>
<p>Supplementary Figure S4. Immunofluorescence using CD68 Cy5 on mouse lung tissues harvested after 18 months of intratracheal treatment. Magenta stain represent antibody and blue nuclear counterstain DAPI. Left, representative image for PBS administration. Right, mice administered NB (NNK BaP).</p>