A5004906997- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Medical Imaging Techniques and Applications
- Advanced X-ray and CT Imaging
- Radiation Detection and Scintillator Technologies
- Head and Neck Cancer Studies
- Lung Cancer Diagnosis and Treatment
- Radiation Dose and Imaging
- Wireless Body Area Networks
- Radiation Effects and Dosimetry
- Advances in Oncology and Radiotherapy
- Chemical Reactions and Isotopes
- Radiomics and Machine Learning in Medical Imaging
- Modular Robots and Swarm Intelligence
- BRCA gene mutations in cancer
- Boron Compounds in Chemistry
- Particle Detector Development and Performance
- Advanced Measurement and Metrology Techniques
- Soft Robotics and Applications
- Engineering Applied Research
- Brain Metastases and Treatment
- Radiation Effects in Electronics
- Assembly Line Balancing Optimization
- Diamond and Carbon-based Materials Research
- Robotic Locomotion and Control
University Hospital of Bern
2016-2024
University of Bern
2016-2024
German University in Cairo
2018
Istanbul Yeni Yüzyıl University
2018
Fachhochschule Wiener Neustadt
2010
We compared dynamic trajectory radiotherapy (DTRT) to state-of-the-art volumetric modulated arc therapy (VMAT) for 46 head and neck cancer cases. DTRT had lower dose salivary glands swallowing structure, resulting in predicted xerostomia dysphagia VMAT. is deliverable on C-arm linacs with high dosimetric accuracy.
Although volumetric modulated arc therapy (VMAT) is a well-accepted treatment technique in radiotherapy using coplanar delivery approach, VMAT might be further improved by including dynamic table and collimator rotations leading to trajectory (DTRT). In this work, an optimization procedure for DTRT was developed the potential benefit of investigated different sites.
The aim of this work is to develop and investigate an inverse treatment planning process (TPP) for mixed beam radiotherapy (MBRT) capable performing simultaneous optimization photon electron apertures.
Non-coplanar radiotherapy treatment techniques on C-arm linear accelerators have the potential to reduce dose organs-at-risk in comparison with coplanar techniques. Accurately predicting possible collisions between gantry, table and patient during planning is needed ensure safety. We offer a freely available collision prediction tool using Blender, free open-source 3D computer graphics software toolset. A geometric model of accelerator including library models created inside Blender. Based...
Objective.The computational effort to perform beamlet calculation, plan optimization and final dose calculation of a treatment planning process (TPP) generating intensity modulated plans is enormous, especially if Monte Carlo (MC) simulations are used for calculation. The goal this work improve the efficiency fully MC based TPP static dynamic photon, electron mixed photon-electron techniques by implementing multiple methods studying influence their parameters.Approach.A framework implemented...
Standard electron treatments are currently still performed using standard or molded patient-specific cut-outs placed in the applicator. Replacing and applicators with a photon multileaf collimator (pMLC) for beam collimation would make more efficient facilitate advanced treatment techniques like modulated radiotherapy (MERT) mixed (MBRT). In this work, multiple source Monte Carlo model pMLC shaped beams commissioned at source-to-surface distance (SSD) of 70 cm is extended SSDs up to 100...
Purpose The purpose of this study was to develop a treatment technique for dynamic mixed beam radiotherapy ( DYMBER ) utilizing increased degrees freedom (DoF) conventional unit including different particle types (photons and electrons), intensity energy modulation gantry, table, collimator rotations. Methods A planning process has been developed create plans combining photon trajectories DT s) step shoot electron apertures collimated with the multileaf pMLC ). gantry‐table path is...
Abstract Objective. The purpose of this study is to develop a treatment planning process (TPP) for non-isocentric dynamic trajectory radiotherapy (DTRT) using gantry rotation, collimator table longitudinal, vertical and lateral translations intensity modulation validate the dosimetric accuracy. Approach. TPP consists two steps. First, path describing rotation determined. Second, an optimization along performed. We demonstrate three use cases. DTRT plan brain case compared isocentric in terms...
To improve organ at risk (OAR) sparing, dynamic trajectory radiotherapy (DTRT) extends VMAT by table and collimator rotation during beam-on. However, comprehensive investigations regarding the impact of gantry-table (GT) gradient on DTRT plan quality have not been conducted.To investigate a user-defined GT plans in terms dosimetric quality, robustness, deliverability, delivery time.The trajectories are described gantry-collimator paths. The path is determined minimizing overlap OARs with...
Dynamic trajectory radiotherapy (DTRT) extends volumetric modulated arc therapy (VMAT) with dynamic table and collimator rotation during beam-on. The aim of the study is to establish DTRT path-finding strategies, demonstrate deliverability dosimetric accuracy compare state-of-the-art VMAT for common head neck (HN) cancer cases.A publicly available library seven HN cases was created on an anthropomorphic phantom all relevant organs-at-risk (OARs) delineated. plans were generated beam...
Abstract Objective. Presently electron beam treatments are delivered using dedicated applicators. An alternative is the usage of already installed photon multileaf collimator (pMLC) enabling efficient treatments. Currently, commissioning models a manual and time-consuming process. In this work an auto-commissioning procedure for Monte Carlo (MC) model part representing above pMLC developed TrueBeam systems with energies from 6 to 22 MeV. Approach. The analytical includes main source primary...
The purpose of this work was to develop a hybrid column generation (CG) and simulated annealing (SA) algorithm for direct aperture optimization (H-DAO) show its effectiveness in generating high quality treatment plans intensity modulated radiation therapy (IMRT) mixed photon-electron beam radiotherapy (MBRT). H-DAO overcomes limitations the CG-DAO with two features improving selection (branch-feature) enabling shape changes during (SA-feature). iteratively adds apertures plan. At each...
Evaluating plan robustness is a key step in radiotherapy.To develop flexible Monte Carlo (MC)-based calculation and evaluation tool to assess quantify dosimetric of intensity-modulated radiotherapy (IMRT) treatment plans by exploring the impact systematic random uncertainties resulting from patient setup, anatomy changes, mechanical limitations machine components.The consists two parts: first part includes automated MC dose multiple user-defined uncertainty scenarios populate space. An...
Dynamic trajectory radiotherapy (DTRT) and dynamic mixed-beam arc therapy (DYMBARC) exploit non-coplanarity and, for DYMBARC, simultaneously optimized photon electron beams. Margin concepts to account set-up uncertainties during delivery are ill-defined fields. We develop robust optimization DTRT&DYMBARC compare dosimetric plan quality robustness both techniques strategies four cases.
Abstract Purpose. To develop a novel treatment planning process (TPP) with simultaneous optimization of modulated photon, electron and proton beams for improved plan quality in radiotherapy. Methods. A framework fluence map Monte Carlo (MC) calculated beamlet dose distributions is developed to generate plans consisting spot scanning fields. Initially, in-house intensity therapy (IMPT) are compared created by commercial system (TPS). triple beam radiotherapy (TriB-RT) generated an exemplary...
Dynamic trajectory radiotherapy (DTRT) extends state-of-the-art volumetric modulated arc therapy (VMAT) by dynamic table and collimator rotations during beam-on. The effects of intrafraction motion DTRT delivery are unknown, especially regarding the possible interplay between patient machine with additional axes.To experimentally assess technical feasibility quantify mechanical dosimetric accuracy respiratory gating delivery.A VMAT plan created for a clinically motivated lung cancer case...
Objective. Electron arcs in mixed-beam radiotherapy (Arc-MBRT) consisting of intensity-modulated electron with dynamic gantry rotation potentially reduce the delivery time compared to containing beams static angle (Static-MBRT). This study aims develop and investigate a treatment planning process (TPP) for photon multileaf collimator (pMLC) based Arc-MBRT.Approach. An existing TPP Static-MBRT plans is extended integrate intensity modulation using sliding window technique. The consists manual...
This work aims to develop, implement and validate a Monte Carlo (MC)-based independent dose calculation (IDC) framework perform patient-specific quality assurance (QA) for multi-leaf collimator (MLC)-based CyberKnife® (Accuray Inc., Sunnyvale, CA) treatment plans. The IDC uses an XML-format plan as exported from the planning system (TPS) DICOM format patient CT data, MC beam model using phase spaces, CyberKnife MLC modifier transport EGS++ class library, sampling coordinate transformation...
Vendor-independent Monte Carlo (MC) dose calculation (IDC) for patient-specific quality assurance of multi-leaf collimator (MLC) based CyberKnife treatments is used to benchmark and validate the commercial MC engine MLC built into treatment planning system (Precision MC).The included profiles in water 15 mm depth curves rectangular shaped fields ranging from 7.6 × 7.7 115.0 100.1 mm, which were compared between IDC, Precision measurements terms difference distance agreement. Dose...
Abstract Background Non‐coplanar techniques have shown to improve the achievable dose distribution compared standard coplanar for multiple treatment sites but finding optimal beam directions is challenging. Dynamic collimator trajectory radiotherapy (colli‐DTRT) a new intensity modulated technique that uses non‐coplanar partial arcs and dynamic rotation. Purpose To solve angle optimization (BAO) problem colli‐DTRT VMAT (NC‐VMAT) by determining table‐angle gantry‐angle ranges of through...
Abstract Purpose The objectives of the work presented in this paper were to (1) implement a robust‐optimization method for deliverable mixed‐beam radiotherapy (MBRT) plans within previously developed MBRT planning framework; (2) perform an experimental validation delivery robust‐optimized plans; and (3) compare PTV‐based terms target dose robustness organs at risk (OAR) sparing clinical head neck brain patient cases. Methods A method, which accounts translational setup errors, was...
Most radiotherapy treatments are performed with high-energy photons. Particles have both advantages and disadvantages compared to photons regarding their dosimetric characteristics, availability, radiobiological properties. In this article, we investigate how optimally combine particles. We introduce treatment plan optimization methodology simultaneously optimize multiple radiation modalities for three applications: 1) electron–photon combinations illustrated a superficial tumor, where...
Non-isocentric dynamic trajectory radiotherapy (DTRT) involves table translations in synchrony with intensity modulation and gantry, table, and/or collimator rotation. This work aims to develop evaluate a novel dosimetrically motivated path determination technique for non-isocentric DTRT.