A5088973985- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Medical Imaging Techniques and Applications
- Lung Cancer Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Congenital Diaphragmatic Hernia Studies
- Atomic and Subatomic Physics Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Radiomics and Machine Learning in Medical Imaging
- Gamma-ray bursts and supernovae
- Radiation Detection and Scintillator Technologies
- Particle Accelerators and Free-Electron Lasers
- Ultrasound in Clinical Applications
- Advances in Oncology and Radiotherapy
Paul Scherrer Institute
2020-2024
Proton (Malaysia)
2024
ETH Zurich
2020-2023
University Hospital of Bern
2021
University of Bern
2021
Respiratory motion is one of the major challenges in radiotherapy. In this work, a comprehensive and clinically plausible set 4D numerical phantoms, together with their corresponding "ground truths," have been developed validated for radiotherapy applications.The phantoms are based on CTs providing density information from multi-breathing-cycle Magnetic Resonance imagings (MRIs). Deformable image registration (DIR) has utilized to extract fields 4DMRIs establish inter-subject correspondence...
Objective.4D dose calculation (4DDC) for pencil beam scanned (PBS) proton therapy is typically based on phase-sorting of individual beams onto phases a single breathing cycle 4DCT. Understanding the dosimetric limitations and uncertainties this approach essential, especially realistic treatment scenario with irregular free motion.Approach.For three liver lung cancer patient CTs, deformable multi-cycle motion from 4DMRIs was used to generate six synthetic 4DCT(MRI)s, providing (11/15 cycles...
Objective.4D dose reconstruction in proton therapy with pencil beam scanning (PBS) typically relies on a single pre-treatment 4DCT (p4DCT). However, breathing motion during the fractionated treatment can vary considerably both amplitude and frequency. We present novel 4D method combining delivery log files patient-specific models, to account for dosimetric effect of intra- inter-fractional variability.Approach.Correlation between an external surrogate anatomical deformations p4DCT is...
Abstract Objective. Magnetic resonance (MR) is an innovative technology for online image guidance in conventional radiotherapy and also starting to be considered proton therapy as well. For MR-guided therapy, particularly plan adaptations, fast dose calculation essential. Monte Carlo (MC) simulations, however, which are the gold standard calculations, very time-consuming. To address need efficient approach MRI-guided we have developed a GPU-based modification of analytical algorithm...
Abstract Objective. Online magnetic resonance imaging (MRI) guidance could be especially beneficial for pencil beam scanned (PBS) proton therapy of tumours affected by respiratory motion. For the first time to our knowledge, we investigate dosimetric impact motion on MRI-guided compared scenario without field. Approach. A previously developed analytical dose calculation algorithm accounting perpendicular fields was extended enable 4D calculations. two geometrical phantoms and three liver...
Motion mitigation strategies are crucial for scanned particle therapy of mobile tumours in order to prevent geometrical target miss and interplay effects. We developed a patient-specific respiratory motion model based on simultaneously acquired time-resolved volumetric MRI 2D abdominal ultrasound images. present its effects 4D pencil beam treatment planning simulated dose distributions. Given an image the liver diaphragm, principal component analysis Gaussian process regression were applied...
Abstract Pencil beam scanned (PBS) proton therapy of lung tumours is hampered by respiratory motion and the motion-induced density changes along path. In this simulation study, we aim to investigate effectiveness tracking for both under ideal conditions in conjunction with a model guided real-time ultrasound imaging liver. Multiple-breathing-cycle 4DMRIs thorax abdominal 2D images were acquired simultaneously five volunteers. Deformation vector fields extracted from 4DMRI, referred as ground...
Abstract Purpose The objectives of the work presented in this paper were to (1) implement a robust‐optimization method for deliverable mixed‐beam radiotherapy (MBRT) plans within previously developed MBRT planning framework; (2) perform an experimental validation delivery robust‐optimized plans; and (3) compare PTV‐based terms target dose robustness organs at risk (OAR) sparing clinical head neck brain patient cases. Methods A method, which accounts translational setup errors, was...
Purpose
4D computed tomography (4DCT) is the clinical standard to image organ motion in radiotherapy, although it limited imaging breathing variability. We propose a method transfer across longitudinal datasets include intra-patient variability and verify its performance lung cancer patients. 
Methods 
Five repeated control 4DCTs for 6 non-small cell patients were combined into multi-breath (m4DCT) by merging stages of deformable registration isolate respiratory motion. The...
Abstract Background Numerical 4D phantoms, together with associated ground truth motion, offer a flexible and comprehensive data set for realistic simulations in radiotherapy radiology target sites affected by respiratory motion. Purpose We present an openly available upgrade to previously reported methods generating 4DCT lung numerical which now incorporate ribcage motion improved density representation throughout the breathing cycle. Methods Density information of reference CTs, toget her...