A5036999003- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Atomic and Subatomic Physics Research
- Lung Cancer Diagnosis and Treatment
- Advanced Chemical Sensor Technologies
- Radiomics and Machine Learning in Medical Imaging
- Radiation Effects and Dosimetry
- Medical Imaging Techniques and Applications
- Radiation Detection and Scintillator Technologies
- Boron Compounds in Chemistry
- Photocathodes and Microchannel Plates
- Nuclear Physics and Applications
- Electron and X-Ray Spectroscopy Techniques
- Laser Design and Applications
- Particle accelerators and beam dynamics
- Advances in Oncology and Radiotherapy
- Advanced MRI Techniques and Applications
Paul Scherrer Institute
2022-2024
ETH Zurich
2022-2023
In proton therapy, the gantry, as final part of beamline, has a major effect on beam intensity and size at isocenter. Most conventional optics cyclotron-based gantries have been designed with an imaging factor between 1 2 from coupling point (CP) gantry entrance to isocenter (patient location) meaning that achieve clinically desirable (small) isocenter, small is also required CP. Here we will show such factors are limiting emittance which can be transported through gantry. We, therefore,...
Abstract Purpose Energy changes in pencil beam scanning proton therapy can be a limiting factor delivery time, hence, patient throughput and the effectiveness of motion mitigation techniques requiring fast irradiation. In this study, we investigate feasibility performing continuous energy modulation within momentum acceptance clinical beamline for therapy. Methods The alternative use local degrader at gantry coupling point has been compared with more common upstream regulation. Focusing on...
To investigate the impact of organ motion on hypoxia-guided proton therapy treatments for non-small cell lung cancer (NSCLC) patients.Hypoxia PET and 4D imaging data six NSCLC patients were used to simulate with different mitigation strategies including rescanning, breath-hold, respiratory gating tumour tracking. Motion-induced dose degradation was estimated treatment plans painting hypoxic sub-volumes at escalated levels. Tumour control probability (TCP) dosimetry indices assessed weigh...
Objective. Investigating the aspects of proton beam delivery to track organ motion with pencil scanning therapy. Considering current systems as a reference, specify requirements for next-generation units aiming at real-time image-guided treatments.Approach. Proton treatments six non-small cell lung cancer (NSCLC) patients were simulated using repeated 4DCTs model respiratory variability. Energy corrections required this treatment site evaluated different approaches tumour tracking, focusing...
Purpose
4D computed tomography (4DCT) is the clinical standard to image organ motion in radiotherapy, although it limited imaging breathing variability. We propose a method transfer across longitudinal datasets include intra-patient variability and verify its performance lung cancer patients. 
Methods 
Five repeated control 4DCTs for 6 non-small cell patients were combined into multi-breath (m4DCT) by merging stages of deformable registration isolate respiratory motion. The...
Background and purposeImaging of respiration-induced anatomical changes is essential to ensure high accuracy in radiotherapy lung cancer. We expanded here on methods for retrospective reconstruction time-resolved volumetric magnetic resonance (4DMR) the thoracic region benchmarked results against 4D computed tomography (4DCT).Materials methodMR data six cancer patients were collected by interleaving cine-navigator images with 2D frame images, acquired across thorax. The have been stacked...