A5047207259- Radiation Therapy and Dosimetry
- Advanced Radiotherapy Techniques
- Particle accelerators and beam dynamics
- Radiation Detection and Scintillator Technologies
- Particle Accelerators and Free-Electron Lasers
- Nuclear Physics and Applications
- Effects of Radiation Exposure
- Radiation Effects in Electronics
- Glioma Diagnosis and Treatment
- Management of metastatic bone disease
- Particle Detector Development and Performance
- Atomic and Subatomic Physics Research
- Boron Compounds in Chemistry
- Superconducting Materials and Applications
- Nuclear reactor physics and engineering
- Magnetic confinement fusion research
- Spacecraft and Cryogenic Technologies
- Radiation Effects and Dosimetry
- Gyrotron and Vacuum Electronics Research
- Nuclear physics research studies
- Astronomical and nuclear sciences
- Tracheal and airway disorders
- Oral health in cancer treatment
- Restraint-Related Deaths
- Magnetic Bearings and Levitation Dynamics
Paul Scherrer Institute
2014-2023
University of Groningen
2009-2022
University Medical Center Groningen
2009-2022
University of Zurich
2007-2008
Zorginstituut Nederland
1995-2006
Scherrer (Switzerland)
2003
Avoiding irradiation of the region parotid gland containing stem cells reduces risk xerostomia (dry mouth).
Background: This study aimed at evaluating spatially varying instantaneous dose rates for different intensity-modulated proton therapy (IMPT) planning strategies and delivery scenarios, comparing these with FLASH (>40 Gy/s).Material methods: In order to quantify in three-dimensions, we proposed the 'dose-averaged rate' (DADR) metric, defined each voxel as dose-weighted mean of all spots (i.e., pencil beams). concept was applied four head-and-neck cases, planned clinical (4 fields) various...
In left-sided breast cancer radiotherapy, tangential intensity modulated radiotherapy combined with breath-hold enables a dose reduction to the heart and left anterior descending (LAD) coronary artery. Aim of this study was investigate added value proton therapy (IMPT) regard decreasing radiation these structures.In comparative planning study, four treatment plans were generated in 20 patients: an IMPT plan IMRT plan, both free-breathing. At least 97 % target volume had be covered by at 95...
Purpose: The purpose of this work was to provide a flexible platform for FLASH research with protons by adapting former clinical pencil beam scanning gantry irradiations ultrahigh dose rates. Methods: PSI Gantry 1 treated patients until December 2018. We optimized the beamline parameters transport 250 MeV extracted from COMET accelerator treatment room, maximizing transmission intensity sample. characterized monitor on ensure good control dose, delivered in spot-scanning mode. different...
We present a design of superconducting magnets, optimized for application in gantry proton therapy. have introduced new magnet concept, called an alternating-gradient canted cosine theta (AG-CCT) which is compatible with achromatic layout. This layout allows large momentum acceptance. The 15 cm radius the bore aperture enables pencil beam scanning front SC-magnet. optical and dynamic performance based on these magnets has been analyzed using fields derived (via Biot-Savart law) from actual...
In many thoracic cancers, the radiation dose that can safely be delivered to target volume is limited by tolerance of surrounding lung tissue. It has been hypothesized irradiation heart may an additional risk factor for development early radiation-induced morbidity. current study, dependence on determined. Fifty percent rat lungs were irradiated either including or excluding heart. Proton beams used allow very accurate and conformal delivery. Lung function toxicity was scored using a...
Monte Carlo simulations based on the Geant4 simulation toolkit were performed for carbon wedge degrader used in beam line at Center of Proton Therapy Paul Scherrer Institute (PSI). The are part studies development and understanding GANTRY2 OPTIS2 treatment facilities PSI, but can also be applied to other lines. simulated stopping power, momentum distributions exit transmission have been compared accurate benchmark measurements. Because transport through magnetic elements is not easily...
Proton therapy can be particularly sensitive to changes or errors in range. Thus, methods for the vivo measurement of range could great use improve quality and accuracy proton-based radiotherapy. In this paper, we introduce concept 'range probe'. This is a low-dose, high-energy proton pencil beam that would pass through patient, whose integral Bragg peak measured on exit side using multi-layer detector. We propose by comparing with calculated based patient's planning CT, such probe provide...
When using superconducting (SC) magnets in a gantry for proton therapy, the will benefit from some reduction size and large weight. In this contribution we show an important additional advantage of SC therapy treatments. We present design with bending section achromatic beam optics very momentum acceptance [Formula: see text]15% (corresponding to about text]30% energy domain). Due related acceptance, approximately 70% treatments can be performed without changing magnetic field...
In proton therapy, the potential of using high-dose rates in cancer treatment is being explored. High-dose could improve efficiency and throughput standard clinical practice, allow efficient utilization motion mitigation techniques for moving targets, potentially enhance normal tissue sparing due to so-called FLASH effect. However, are difficult reach when lower energy beams applied cyclotron-based therapy facilities, because they result large beam sizes divergences downstream degrader,...
In proton therapy, the gantry, as final part of beamline, has a major effect on beam intensity and size at isocenter. Most conventional optics cyclotron-based gantries have been designed with an imaging factor between 1 2 from coupling point (CP) gantry entrance to isocenter (patient location) meaning that achieve clinically desirable (small) isocenter, small is also required CP. Here we will show such factors are limiting emittance which can be transported through gantry. We, therefore,...
An overview is given of different techniques dose delivery applied in currently operating and planned particle therapy systems. Their advantages disadvantages will be compared consequences the methods for rest instrumentation discussed. The interrelationship between beam at patient accelerator system shown by means several concrete examples. Apart from a description subsystems facility, design rules optimizing reliability an discussed, as well some remarks concerning how to deal with future...