A5075848871- Head and Neck Cancer Studies
- Oral health in cancer treatment
- Cancer Diagnosis and Treatment
- Salivary Gland Disorders and Functions
- Advanced Radiotherapy Techniques
- Salivary Gland Tumors Diagnosis and Treatment
- Oral Health Pathology and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Cancer Genomics and Diagnostics
- Hematopoietic Stem Cell Transplantation
- Cytomegalovirus and herpesvirus research
- Voice and Speech Disorders
- Botulinum Toxin and Related Neurological Disorders
- Healthcare cost, quality, practices
- Oral and gingival health research
- Herpesvirus Infections and Treatments
- Drug Transport and Resistance Mechanisms
- Liver Disease Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Biochemical Analysis and Sensing Techniques
- Oral and Maxillofacial Pathology
- Effects of Radiation Exposure
- Respiratory and Cough-Related Research
- Liver Diseases and Immunity
- T-cell and B-cell Immunology
BC Cancer Agency
2004-2025
University of British Columbia
2003-2014
University of California, San Diego
2014
Simon Fraser University
2006
Vancouver Hospital and Health Sciences Centre
2006
Avoiding irradiation of the region parotid gland containing stem cells reduces risk xerostomia (dry mouth).
Despite advances in transplant medicine, prevalence of complications after hematopoietic stem cell transplantation (HSCT) remains high. The impact pre-HSCT oral health factors on the incidence and severity post-HSCT is poorly understood. aim this prospective, observational study was to analyze patients planned for HSCT. Patients ≥18 years requiring HSCT were included from five sites between 2011–2018. General health, findings patient-reported symptoms registered 272 patients. Oral around...
The oral cavity is a common site of complications related to the cytotoxic effect high-dose chemotherapy and radiation therapy. Considering our limited understanding burden illness in from various therapies, it difficult produce evidence-based, preventive management protocols. A prospective multicenter study necessary collect data on regimens.The objectives this international observational hematopoietic stem cell transplant (HSCT) patients are establish nature, incidence temporal...
Xerostomia, or subjective oral dryness, is a serious complaint after haematopoietic cell transplantation (HCT). Xerostomia rated as one of the most bothersome symptoms by HCT recipients, affecting quality life negatively. This sub-study Orastem study, prospective, longitudinal, international, observational, multicentre aims to describe prevalence and severity xerostomia following HCT. Furthermore, effect conditioning regimen, type mucosal changes related chronic graft-versus-host disease...
Parotid glands are treated clinically as though the distribution of functional burden were homogeneous. Radiotherapy treatments planned using whole parotid mean dose to predict risk salivary dysfunction. Recent progress has identified specific non-homogeneities by demonstrating existence regional, bath-and-shower, and dose-volume effects. In this work, regional effects their impact on function quantified a non-parametric (model-free) approach. Regional have implications for clinical sparing...
Xerostomia is one of the most likely late toxic effects radiotherapy treatment in patients with head-and-neck cancers. Modern techniques can incorporate knowledge complication risk into plans. To this end, authors attempt to quantify regional dose-dependence salivary output loss and recovery a prospective study.Salivary was collected from undergoing for cancers at BC Cancer Agency between February 2008 May 2013. Regional (i.e., dose susceptibility) quantified using nonparametric (Spearman's...
Abstract Background This study leverages a large retrospective cohort of head and neck cancer patients in order to develop machine learning models predict radiation induced hyposalivation from dose-volume histograms the parotid glands. Methods The pre post-radiotherapy salivary flow rates 510 were used fit three predictive hypofunction, (1) Lyman-Kutcher-Burman (LKB) model, (2) spline-based (3) neural network. A fourth LKB-type model using literature reported parameter values was included...
Abstract Introduction Chronic graft-versus-host disease (cGVHD) is a debilitating side effect of allogeneic hematopoietic cell transplantation (HCT), affecting the quality life patients. We used whole exome sequencing to identify candidate SNPs and complete multi-marker gene-level analysis using cohort cGVHD( +) ( N = 16) −) 66) HCT Methods Saliva samples were collected from patients 82) pre-conditioning in multi-center study March 2011 May 2018. Exome was performed FASTQ files processed for...