A5054994151- Venomous Animal Envenomation and Studies
- Amphibian and Reptile Biology
- Rabies epidemiology and control
- Marine Invertebrate Physiology and Ecology
- Healthcare and Venom Research
- Insect and Pesticide Research
- Vector-borne infectious diseases
- Biochemical and Structural Characterization
- Algal biology and biofuel production
- Antimicrobial Peptides and Activities
- Enzyme Catalysis and Immobilization
- Oral health in cancer treatment
- Breast Cancer Treatment Studies
- Primate Behavior and Ecology
- Curcumin's Biomedical Applications
- Adipokines, Inflammation, and Metabolic Diseases
- Yersinia bacterium, plague, ectoparasites research
- Head and Neck Cancer Studies
- Hemoglobinopathies and Related Disorders
- Adipose Tissue and Metabolism
- Microbial Metabolic Engineering and Bioproduction
- Turtle Biology and Conservation
- Blood groups and transfusion
- Bioactive Natural Diterpenoids Research
- Pesticide Residue Analysis and Safety
Instituto Butantan
2017-2025
Universidade de São Paulo
2013-2025
University Medical Center Utrecht
2024
Utrecht University
2024
Fundação Centro de Hematologia e Hemoterapia de Minas Gerais
2023
Instituto de Pesquisas Tecnológicas
2017-2022
Universidade Estadual Paulista (Unesp)
2020
Universidade Federal de São Paulo
2020
Museu de Ciências Naturais da Fundação Zoobotânica do Rio Grande do Sul
2020
Universidade Federal de Minas Gerais
2020
Five non-toxin producing cyanobacterial isolates from the genera Synechococcus, Trichormus, Microcystis, Leptolyngbya and Chlorogloea were examined in terms of quantity quality as lipid feedstock for biofuel production. Under conditions used this study, biomass productivity ranged 3.7 to 52.7 mg·L−1·day−1 relation dry biomass, while varied between 0.8 14.2 mg·L−1·day−1. All strains evaluated yielded lipids with similar fatty acid composition those present seed oils successfully biodiesel...
Crotalus durissus is considered one of the most important species venomous snakes in Brazil, due to high mortality its snakebites. The venom contains four main toxins: crotoxin, convulxin, gyroxin and crotamine. Venoms can vary their crotamine content, being crotamine-negative or -positive. This heterogeneity great importance for producing antivenom, different mechanisms action. possibility that antivenom produced by Butantan Institute might have a immunorecognition capacity between...
Background: Variability in snake venoms is a well-studied phenomenon. However, sex-based variation of Bothrops atrox venom using siblings poorly investigated. responsible for the majority snakebite accidents Brazilian Amazon region. Differences composition genus have been linked to several factors such as ontogeny, geographical distribution, prey preferences and sex. Thus, current study, samples male female were analyzed order compare their biochemical biological characteristics. Methods:...
Snakebite envenoming is a global health problem, leading to the search for different sources of biomolecules supplement current antivenom therapy. Snake venom serine proteases are abundant in Viperidae venoms and responsible disruptions hemostatic system. Previous studies have shown that English potato (Solanum tuberosum) source Kunitz-type protease inhibitors. In this work, inhibitor from S. tuberosum was isolated, its inhibitory capacity on proteolytic activities Bothrops jararaca snake...
Phospholipases A2 (PLA2) are enzymes acting on the cell membrane phospholipids resulting in fatty acids and lysophospholipids deconstructing membrane. This protein is commonly found snake venoms, causing tissue inflammation affected area. Evidence indicates that snakes have natural resistance to their own venom due protective properties plasma, inhibit action of proteins present venom. Given that, this study aimed purify characterize a γPLI from Bothrops jararaca serum, named γBjPLI. PLA2...
The Brazilian lancehead (Bothrops moojeni) has a wide distribution in Brazil and represents serious public health hazard. Previous works reported that the symptoms of snakebites caused by B. moojeni juveniles' bites were mainly related to coagulation, while those adults' had more prominent local damage. In this work, we analyzed venoms at different life stages better understand ontogeny shift species. Snakes grouped age sex, venom pools formed accordingly. Compositional analyses...
South American rattlesnakes are represented in Brazil by a single species, Crotalus durissus, which has public health importance due to the severity of its envenomation and wide geographical distribution. The species is subdivided into several subspecies, but current classification controversial. In Brazil, venoms C. d. terrificus collilineatus used for hyperimmunization horses antivenom production, even though distinction these two subspecies mostly their this context, we described...
Snake venoms are complex protein mixtures with different biological activities that can act in both their preys and human victims. Many of these proteins play a role prey capture the digestive process animals. It is known some snakes resistant to toxicity own venom by mechanisms not yet fully elucidated. However, it was observed Laboratory Herpetology Instituto Butantan Bothrops moojeni individuals injured same snake species showed mortalities caused envenoming effects. This study analyzed...
Plasma in several organisms has components that promote resistance to envenomation by inhibiting specific proteins from snake venoms, such as phospholipases A2 (PLA2s). The major hypothesis for inhibitor's presence would be the protection against self-envenomation venomous snakes, but occurrence of inhibitors non-venomous snakes and other animals opened new perspectives this molecule. Thus, study showed first time structural functional characterization PLA2 inhibitor Boa constrictor serum...
Antithrombin inhibits blood coagulation through the interaction with serine proteases in both intrinsic and extrinsic pathways. In addition, antithrombin also shows anti-inflammatory properties, which are independent of its effects on coagulation. This work for first time cloning sequencing from a snake species. predicted protein is composed by 430 amino acids presents about 64.5% sequence identity to human antithrombin. Biacore experiments revealed that binding affinity Bothrops jararaca...
In Brazil, the genus Bothrops is responsible for most ophidian accidents. Snake venoms have a wide variety of proteins and peptides exhibiting broad repertoire pharmacological toxic effects that elicit systemic injury characteristic local effects. The snakes’ natural resistance to envenomation caused by presence inhibitory compounds on their plasma been extensively studied. However, these inhibitors in different developmental stages yet be further discussed. aim this study was evaluate...