A5023419181- Advanced Radiotherapy Techniques
- Management of metastatic bone disease
- Medical Imaging Techniques and Applications
- Brain Metastases and Treatment
- Lung Cancer Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Radiopharmaceutical Chemistry and Applications
- Glioma Diagnosis and Treatment
- Spine and Intervertebral Disc Pathology
- MRI in cancer diagnosis
- Rheumatoid Arthritis Research and Therapies
- Cancer Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Gastric Cancer Management and Outcomes
- Advances in Oncology and Radiotherapy
- Colorectal Cancer Surgical Treatments
- Advanced X-ray and CT Imaging
- Vascular Malformations Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Protease and Inhibitor Mechanisms
- Spinal Fractures and Fixation Techniques
- Brain Tumor Detection and Classification
- Peptidase Inhibition and Analysis
- Systemic Sclerosis and Related Diseases
University Hospital of Bern
2018-2024
University of Bern
2018-2024
Medical University of Vienna
2022
University Hospital of Zurich
2007-2019
University of Zurich
2007-2019
Swiss Integrative Center for Human Health
2009
Abstract Objective Rheumatoid arthritis (RA) is a chronic inflammatory disorder of unknown origin. Histone deacetylase (HDA) activity considered to play major role in the transcriptional regulation proinflammatory genes. We undertook this study investigate balance histone acetylase and HDA synovial tissue from RA patients compared with that osteoarthritis (OA) normal controls. Methods Activity acetylases HDAs was measured nuclear extracts total samples, which were obtained OA undergoing...
Abstract Objective Tissue fibrosis is a hallmark compromising feature of many disorders. In this study, we investigated the antifibrogenic effects histone deacetylase inhibitor trichostatin A (TSA) on cytokine‐driven fibrotic responses in vitro and vivo. Methods Skin fibroblasts from patients with systemic sclerosis (SSc) normal healthy control subjects were stimulated profibrotic cytokines combination TSA. Human Colα1(I) fibronectin measured using real‐time polymerase chain reaction, levels...
Abstract Background The purpose of this randomised study was to determine whether dose‐intensified stereotactic body radiotherapy (SBRT) for painful vertebral metastases results in increased rates pain improvement compared with conventional external beam (cEBRT) (control) 6 months after treatment. Methods This randomized, controlled phase 3 trial conducted between November 2016 and January 2023, when it stopped early. Patients were eligible if they aged 18 years or older; had one two...
Abstract Objective We have recently shown a significant reduction in cytokine‐induced transcription of type I collagen and fibronectin systemic sclerosis (SSc) skin fibroblasts upon treatment with trichostatin A (TSA). Moreover, mouse model fibrosis, TSA prevented the dermal accumulation extracellular matrix. The purpose this study was to analyze silencing histone deacetylase 7 (HDAC‐7) as possible mechanism by which exerts its antifibrotic function. Methods Skin from patients SSc were...
Background and introduction Optimal dose fractionation in stereotactic body radiotherapy (SBRT) for oligometastatic cancer patients remain unknown. In this interim analysis of OligoCare, we analyzed factors associated with SBRT fractionation. Materials methods Analysis was based on the first 1,099 registered patients. doses were converted to biological effective (BED) using α/β 10 Gy all primaries, cancer-specific non-small cell lung colorectal (NSCLC, CRC), 2.5 breast (BC), or 1.5 prostate...
Abstract Objective Since fibroblasts in the synovium of patients with rheumatoid arthritis (RA) express serine proteases fibroblast activation protein (FAP) and dipeptidylpeptidase 4 (DPP‐4)/CD26, we undertook current study to determine functional role both enzymes invasion RA synovial (RASFs) into articular cartilage. Methods Expression FAP DPP‐4/CD26 by RASFs was analyzed using fluorescence‐activated cell sorting immunocytochemistry. Serine protease activity measured cleavage fluorogenic...
Although volumetric modulated arc therapy (VMAT) is a well-accepted treatment technique in radiotherapy using coplanar delivery approach, VMAT might be further improved by including dynamic table and collimator rotations leading to trajectory (DTRT). In this work, an optimization procedure for DTRT was developed the potential benefit of investigated different sites.
Abstract Objective Pattern‐recognition receptors (PRRs), such as Toll‐like (TLRs) and nucleotide‐binding oligomerization domain–containing protein 2 (NOD‐2), have been shown to contribute the pathogenesis of rheumatoid arthritis (RA). The aim this study was analyze expression, regulation, function PRR NOD‐1 in RA synovial fibroblasts (RASFs), examine its interaction with other PRRs. Methods Expression analyzed by immunohistochemistry tissue from patients, psoriatic gout osteoarthritis (OA)...
Abstract Background The use of stereotactic body radiation therapy (SBRT) for tumor and pain control in patients with bone metastases is increasing. We report response assessment after SBRT using radiological changes through time clinical examination patients. Methods analyzed retrospectively oligo-metastatic/progressive bony lesions treated between 12/2008 10/2018, without in-field re-irradiation, our institution. Radiological data were obtained from imaging modalities used planning...
Abstract Background and purpose To assess the feasibility of postoperative stereotactic body radiation therapy (SBRT) for patients with hybrid implants consisting carbon fiber reinforced polyetheretherketone titanium (CFP-T) using CyberKnife. Materials methods All essential steps within a (RT) workflow were evaluated. First, contouring process target volumes organs at risk (OAR) was done CFP-T implants. Second, after RT-planning, accuracy calculated dose distributions tested in slab phantom...
Abstract Objective To search for novel autoantibodies in patients with rheumatoid arthritis (RA) an effort to better understand the processes of joint destruction this disease. Methods Using a modified SEREX technique and complementary DNA derived from RA synovium, serpin E2 was identified as autoantigen analyzed by immunohistochemistry. Levels anti–serpin serum synovial fluid RA, osteoarthritis (OA), psoriatic arthritis, ankylosing spondylitis, and/or healthy individuals were assessed...
Neo-adjuvant chemoradiotherapy (CRT) and perioperative chemotherapy are different strategies for treating non-metastatic esophageal cancer (EC). The advantages of neo-adjuvant therapies primarily seen in patients who achieve a pathologic complete response (pCR) therefore show higher survival rates better prognosis. In general, less than one-third with EC experience pCR after therapies; however, adenocarcinoma (AC) demonstrate lower compared to those squamous cell carcinoma (SCC),...