A5045254537- Advanced Radiotherapy Techniques
- Lung Cancer Diagnosis and Treatment
- Brain Metastases and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Glioma Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Management of metastatic bone disease
- Palliative Care and End-of-Life Issues
- Brain Tumor Detection and Classification
- Advances in Oncology and Radiotherapy
- Hepatocellular Carcinoma Treatment and Prognosis
- Radiopharmaceutical Chemistry and Applications
- Cancer survivorship and care
- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Grief, Bereavement, and Mental Health
- Patient Dignity and Privacy
- Head and Neck Cancer Studies
- Nutrition and Health in Aging
- Radiation Therapy and Dosimetry
- Childhood Cancer Survivors' Quality of Life
- Medical Imaging and Pathology Studies
- Diet and metabolism studies
- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
University Hospital of Zurich
2021-2025
University of Zurich
2021-2024
Charité - Universitätsmedizin Berlin
2024
Dana-Farber Brigham Cancer Center
2023
Harvard University
2015-2023
Brigham and Women's Hospital
2023
Dana-Farber Cancer Institute
2023
Beth Israel Deaconess Medical Center
2015
Abstract Background This study extended the original Dignity Therapy (DT) intervention by including partners and family caregivers (FCs) of terminally-ill cancer patients with overall aim evaluating whether DT can mitigate distress in both nearing end life their FCs. Methods In this multicenter, randomized controlled trial (RCT), a total 68 expectancy < 6 months clinically-relevant stress levels (Hospital Anxiety Depression score; HADS tot ≥ 8) FCs were randomly assigned to DT, +...
This multicenter study assessed the incidence and survival of patients with esophagogastric cancer oligometastatic disease (OMD) in two tertiary referral centers The Netherlands Switzerland.Between 2010 2021, metastatic were identified. Patients de-novo OMD included (first-time diagnosis ≤5 distant metastases on 18F-FDG-PET/CT). Control primary tumor was considered who underwent resection or definitive chemoradiotherapy without locoregional recurrence. Treatment categorized into (1) systemic...
To explore the prognostic value of oligometastatic disease (OMD) states as proposed by European Society for Radiotherapy and Oncology (ESTRO) Organisation Research Treatment Cancer (EORTC) classification system.This retrospective single-institution study included patients with 1-5 extracranial metastases from any solid malignancy treated SBRT to all metastases. OMD were defined according ESTRO EORTC classification. Overall survival (OS) progression-free (PFS) analyzed using Kaplan-Meier...
Although radiation therapy (RT) is an effective and inexpensive pillar of multidisciplinary cancer care, access to RT facilities remains highly inequitable globally. Numerous studies have documented this resource gap, yet many countries continue facing their raging epidemics ill-equipped. In study, we present estimation deficits in low- middle-income (LMICs) without any at all.This study builds on publicly available data country classification, population, incidence, requirements provided by...
Abstract Purpose To assess the effects of daily adaptive MR-guided replanning in stereotactic body radiation therapy (SBRT) liver metastases based on a patient individual longitudinal dosimetric analysis. Methods Fifteen patients assigned to SBRT for oligometastatic underwent target localization and on-table treatment plan re-optimization. Gross tumor volume (GTV) organs at risk (OARs) were adapted anatomy-of-the-day. A reoptimized (RP) rigidly shifted baseline (sBP) without re-optimization...
Abstract Background Surgical resection is the standard of care for patients with large or symptomatic brain metastases (BMs). Despite improved local control after adjuvant stereotactic radiotherapy, risk failure (LF) persists. Therefore, we aimed to develop and externally validate a pre-therapeutic radiomics-based prediction tool identify at high LF risk. Methods Data were collected from A Multicenter Analysis Stereotactic Radiotherapy Resection Cavity BMs (AURORA) retrospective study...
Metastatic disease has been proposed as a continuum, with no clear cut-off between oligometastatic and polymetastatic disease. This study aims to quantify tumor burden patterns of spread in unselected metastatic cancer patients referred for PET-based staging, response assessment restaging.
Background and introduction Optimal dose fractionation in stereotactic body radiotherapy (SBRT) for oligometastatic cancer patients remain unknown. In this interim analysis of OligoCare, we analyzed factors associated with SBRT fractionation. Materials methods Analysis was based on the first 1,099 registered patients. doses were converted to biological effective (BED) using α/β 10 Gy all primaries, cancer-specific non-small cell lung colorectal (NSCLC, CRC), 2.5 breast (BC), or 1.5 prostate...
The importance of timely integration palliative care has been confirmed over the past years for any patient suffering from a life-threatening or life-limiting disease. Palliative and supportive increases quality life patients caregivers in both oncological non-cancer diseases should therefore be offered on needs-based approach throughout disease trajectory. We analyzEd all in-patient consultation requests leading university hospital Switzerland 2019. Sociodemographics, symptoms, specific as...
Stereotactic radiotherapy is a standard treatment option for patients with brain metastases. The planning target volume based on gross tumor (GTV) segmentation. aim of this work to develop and validate neural network automatic GTV segmentation accelerate clinical daily routine practice minimize interobserver variability.We analyzed MRIs (T1-weighted sequence ± contrast-enhancement, T2-weighted sequence, FLAIR sequence) from 348 at least one metastasis different cancer primaries treated in...
Many automatic approaches to brain tumor segmentation employ multiple magnetic resonance imaging (MRI) sequences. The goal of this project was compare different combinations input sequences determine which MRI are needed for effective automated metastasis (BM) segmentation.We analyzed preoperative (T1-weighted sequence ± contrast-enhancement (T1/T1-CE), T2-weighted (T2), and T2 fluid-attenuated inversion recovery (T2-FLAIR) sequence) from 339 patients with BMs seven centers. A baseline 3D...
Surgical resection and stereotactic radiosurgery (SRS) are well-established treatment methods for patients with brain metastases, yet their respective roles in the management of metastases remain incompletely defined.To report on role SRS from malignant melanoma, a retrospective analysis 381 intracranial melanoma 103 consecutive who underwent between 2005 2011 at Beth Israel Deaconess Medical Center was conducted. The Cyberknife(®) system used to treat all patients. Clinical, technical,...
Background: Digital health technologies have potential to transform palliative care (PC) services. The global aging population poses unique challenges for PC, which digital may help overcome. Evaluation of attitudes and perceptions combined with quantification prior use habits favor an understanding psychological barriers PC patient acceptance including artificial intelligence (AI). Objectives: We aimed evaluate the patients regarding a broad range used in their routine monitoring treatment...
To evaluate the potential of artificial intelligence (AI) chatbot ChatGPT in supporting young clinical scientists with scientific tasks radio oncological research.Seven were to be completed 3 h by 8 radiation oncologists different experience working at a university hospital: creation synopsis, research question and corresponding trial hypotheses, writing first paragraph manuscript introduction, sample size calculation, data analyses (multivariate analysis, boxplot survival curve). No...
•Data on cardiac toxicity after SBRT for ultra-central lung tumors remains limited.•We analyzed the dose to 18 sub-structures and cardiovascular toxicity.•A regimen of 45 Gy in 8-10 fractions yields good local control low toxicity.•The highest doses were observed pulmonary artery left atrium.•Higher base heart seem be associated with non-cancer deaths.
BackgroundTreatment of metastatic cancer patients with multiple repeat courses radiotherapy has become more frequent due to their improved overall survival. However, very little is known about long-term outcome. This analysis reports on the quality-of-life, hematologic toxicity, patient-reported experiences and satisfaction, psychological distress treated radiotherapy.MethodsAll ≥5 between 2011 2019 at Department Radiation Oncology, University Hospital Zurich (USZ) were screened for this...
Accurate prediction of survival is important to facilitate clinical decision-making and improve quality care at the end life. While it well documented that poses a challenge for treating physicians, need clinically valuable predictive factors has not been met. This study aims quantify prevalence patient transfer 72 h before death onto acute palliative unit in tertiary center Switzerland, identify 72-h mortality.All patients hospitalized between January December 2020 on Competence Center...
Patients with oligometastatic disease (OMD) treated metastasis-directed definitive local therapy such as stereotactic body radiotherapy (SBRT) are at risk of developing new metastases. Here, we compare characteristics and outcomes patients a single course repeat SBRT.OMD SBRT to 1-5 metastases were included in this retrospective study, classified or SBRT. Progression-free survival (PFS), widespread failure-free (WFFS), overall (OS), systemic therapy-free (STFS) cumulative incidence different...
Choosing the right treatment for patient in a setting of metastatic cancer disease remains challenge. To facilitate clinical decision-making, predictive tools have been developed to personalize treatment. Here, we aim assess use recently proposed "METSSS score" as prognostic tool overall survival patients after palliative radiotherapy last phase life.All treated with at end-of-life Department Radiation Oncology University Hospital Zurich between January 2010 and December 2019 were included...
Patients who develop oligorecurrent disease may be treated with metastasis-directed stereotactic body radiotherapy (SBRT) to defer the start of systemic therapy and delay its potential side effects. We report oncological outcomes patterns failure in patients SBRT determine which factors impact interval initiation therapy.This retrospective study included (≤5 lesions) from any solid organ malignancy, all metastases no for a minimum one month after between 01/2014 12/2019. The Kaplan-Meier...