A5046503712- Medical Imaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Radiation Detection and Scintillator Technologies
- Advanced Radiotherapy Techniques
- Advanced X-ray and CT Imaging
- Radiopharmaceutical Chemistry and Applications
- Nuclear Physics and Applications
- Atomic and Subatomic Physics Research
- Cardiac Imaging and Diagnostics
- Bone health and osteoporosis research
- Diet and metabolism studies
- Bone health and treatments
- Medical Imaging and Pathology Studies
- Radiation Dose and Imaging
- Lung Cancer Diagnosis and Treatment
- Diabetes Management and Research
- Sarcoma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Bone and Joint Diseases
- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Glioma Diagnosis and Treatment
- MRI in cancer diagnosis
- Heart Rate Variability and Autonomic Control
King's College London
2016-2025
St Thomas' Hospital
2016-2025
King's College Hospital
1974-2024
The King's College
2004-2024
Health Service Executive
2010-2024
Lambeth Hospital
2002-2024
King's College School
2003-2022
Guy's and St Thomas' NHS Foundation Trust
1996-2019
Institute of Public Health
2018
Kings Health Partners
2012-2013
The aim of this guideline is to provide a minimum standard for the acquisition and interpretation PET PET/CT scans with [18F]-fluorodeoxyglucose (FDG). This will therefore address general information about[18F]-fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET/CT) provided help physician physicist assist carrying out,interpret, document quantitative FDG examinations,but concentrate on optimisation diagnostic quality information.
There is evidence in some solid tumors that textural features of tumoral uptake <sup>18</sup>F-FDG PET images are associated with response to chemoradiotherapy and survival. We have investigated whether a similar relationship exists non–small cell lung cancer (NSCLC). <b>Methods:</b> Fifty-three patients (mean age, 65.8 y; 31 men, 22 women) NSCLC treated underwent pretreatment PET/CT scans. Response was assessed by CT Evaluation Criteria Solid Tumors (RECIST) at 12 wk. Overall survival (OS),...
Since the seventies, positron emission tomography (PET) has become an invaluable medical molecular imaging modality with unprecedented sensitivity at picomolar level, especially for cancer diagnosis and monitoring of its response to therapy.More recently, combination X-ray computed (CT) or magnetic resonance (MR) added high precision anatomic information in fused PET/CT PET/MR images, thus compensating modest intrinsic spatial resolution PET.Nevertheless, a number challenges call further...
We have developed a prototype PET detector which is compatible with clinical MRI system to provide simultaneous and MR imaging. This single-slice consists of 48 2 x 10 mm3 LSO crystals in 38 mm diameter ring configuration that can be placed inside the receiver coil system, coupled three multi-channel photomultipliers housed outside main magnetic field via 4 m long optical fibres. The exhibits spatial resolution, 41% energy resolution at 511 keV 20 ns timing resolution. Simultaneous phantom...
The effect of basal insulin on global and regional brain glucose uptake metabolism in humans was studied using 18-fluorodeoxyglucose positron emission tomography (FDG-PET). Eight healthy male volunteers aged 49.3 ± 5.1 years were twice random order. On each occasion, they received an infusion 0.1 mg · kg−1 min−1 somatostatin to suppress endogenous production. In one study 0.3 mU infused replace circulating levels, the other a saline used as control. We sought stimulatory effects particularly...
Recent in vitro studies suggest that lactate, rather than glucose, may be the preferred fuel for neuronal metabolism. The authors examined effect of lactate on global brain glucose uptake euglycemic human subjects using 18 fluoro-deoxyglucose (FDG) positron emission tomography (PET). Eight healthy men, aged 40 to 54 years, underwent a 60-minute FDG-PET scan two occasions random order. On one occasion, 6.72% sodium was infused at rate 50 micro mol. kg-1. min-1 20 minutes and then reduced 30...
We report the development of a prototype positron emission tomography (PET) scanner compatible with clinical magnetic resonance imaging (MRI) scanners and nuclear (NMR) spectrometers. This single slice PET system consists 72 2/spl times/2/spl times/5 mm lutetium oxyorthosilicate (LSO) crystals coupled by 2 diameter, 4 meter long double clad optical fibers to three multi-channel photomultiplier tubes (MC-PMTs) shielded inside an aluminum closure. The ring diameter is 54 thickness /spl sim/1...
The rising prevalence of obesity and type 2 diabetes is a global challenge. A possible mechanism linking insulin resistance weight gain would be attenuation insulin-evoked responses in brain areas relevant to eating systemic resistance. We measured glucose metabolism, using [(18)F]fluorodeoxyglucose positron emission tomography, seven insulin-sensitive (homeostasis model assessment [HOMA-IR] = 1.3) insulin-resistant (HOMA-IR 6.3) men, during suppression endogenous by somatostatin, with...
The NanoPET/CT represents the latest generation of commercial preclinical PET/CT systems. This article presents a performance evaluation PET component system according to National Electrical Manufacturers Association (NEMA) NU-4 2008 standard. <b>Methods:</b> consists 12 lutetium yttrium orthosilicate:cerium modular detectors forming 1 ring, with 9.5-cm axial coverage and 16-cm animal port. Each detector crystal is 1.12 × 13 mm, module contains 81 39 these crystals. An optical light guide...
The development of a highly integrated and MRI-compatible PET detector remains as one the main challenges towards truly simultaneous PET/MR scanner. Here we present world's first scanner design "Hyperion II <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">D</sup> " with fully digital silicon photomultiplier technology (dSiPMs). It is based on HYPERImage Insert I" using analog SiPMs demonstrated by Schulz et a!. in [1] [2]. new architecture...
There is currently great interest in combining data from different imaging modalities, either by image registration methods that are performed after the has been acquired or using new devices can acquire two modalities simultaneously, near simultaneously. In this paper a small prototype NMR-compatible PET scanner capable of acquiring images simultaneously with NMR spectra described. an associated [1], Pamela Garlick describes some investigations cardiac metabolism have made system. One main...
Respiratory motion can adversely affect both PET and CT acquisitions. gating allows an acquisition to be divided into a series of motion-reduced bins according the respiratory signal, which is typically hardware acquired. In order that effects potentially corrected for, we have developed novel, automatic, data-driven method retrospectively derives signal from acquired data. data are in listmode analysed sinogram space, cine mode image space. Spectral analysis used identify regions within...
The human sodium/iodide symporter (hNIS) is a well-established target in thyroid disease and reporter gene imaging using gamma emitters 123I-iodide, 131I-iodide 99mTc-pertechnetate. However, no PET agent routinely available. aim of this study was to prepare evaluate 18F-labelled tetrafluoroborate ([18F]TFB) for hNIS. [18F]TFB prepared by isotopic exchange BF 4 − with [18F]fluoride hot hydrochloric acid purified an alumina column. Its identity, purity stability serum were determined HPLC,...
We have implemented and evaluated a framework for simulating simultaneous dynamic PET-MR data using the anatomic information from real MR acquisitions.PET radiotracer distribution is simulated by assigning typical FDG uptake values to segmented images with manually inserted additional virtual lesions.PET projection are analytic forward projections (including attenuation Poisson statistics) within image reconstruction package STIR.PET reconstructions also performed STIR.The simulation...
Cardiac PET is a versatile imaging technique providing important diagnostic information about ischemic heart diseases. Respiratory and cardiac motion of the can strongly impair image quality therefore accuracy scans. The aim this study was to investigate new PET/MR approach respiratory motion–compensated MR images in less than 5 min. <b>Methods:</b> Free-breathing 3-dimensional data were acquired retrospectively binned into multiple states. Three-dimensional fields obtained with nonrigid...
We report the safety, biodistribution, and internal radiation dosimetry, in humans with thyroid cancer, of <sup>18</sup>F-tetrafluoroborate (<sup>18</sup>F-TFB), a novel PET radioligand for imaging human sodium/iodide symporter (hNIS). <b>Methods:</b> Serial whole-body scans 5 subjects recently diagnosed cancer were acquired before surgery up to 4 h after injection 184 ± 15 MBq <sup>18</sup>F-TFB. Activity was determined whole blood, plasma, urine. Mean organ-absorbed doses effective...