A5043648973- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Neuroblastoma Research and Treatments
- Prostate Cancer Treatment and Research
- Neuroendocrine Tumor Research Advances
- Management of metastatic bone disease
- Medical Imaging and Pathology Studies
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Research Studies
- Adrenal and Paraganglionic Tumors
- Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Bone health and treatments
- Lymphoma Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Treatments and Mutations
- Boron Compounds in Chemistry
- Radiation Dose and Imaging
- Prostate Cancer Diagnosis and Treatment
- Advances in Oncology and Radiotherapy
- Radiomics and Machine Learning in Medical Imaging
- Radiation Therapy and Dosimetry
- Monoclonal and Polyclonal Antibodies Research
- Thyroid Cancer Diagnosis and Treatment
- MRI in cancer diagnosis
King's College London
2014-2024
Royal Marsden Hospital
2005-2022
St Thomas' Hospital
2012-2022
Guy's Hospital
2015-2021
Guy's and St Thomas' NHS Foundation Trust
2012-2019
Wellington Hospital
2019
Medical University of Warsaw
2017
The London College
2017
Royal Marsden NHS Foundation Trust
2006-2010
Hampton University
2008
In spite of advances in diagnostic methods, surgical techniques and clinical care, there are differences survival patients with thyroid cancer different countries, the outcome UK prior to 1989 appeared be worse than other western European nations.1 The reasons for this unclear may multifactorial. There is a sense that outcomes improving, but only long term national registry data can confirm or refute future. However, it not unreasonable speculate impact previous editions these guidelines,...
These guidelines update previous guidance published in 2005. They have been revised by a group who are members of the UK and Ireland Neuroendocrine Tumour Society with endorsement from clinical committees British Gastroenterology, for Endocrinology, Association Surgeons Great Britain (and its Surgical Specialty Associations), Gastrointestinal Abdominal Radiology others. The authorship represents leaders various groups Society, but large amount work has carried out other specialists, many...
Neuroblastoma is an enigmatic disease entity; some tumors disappear spontaneously without any therapy, while others progress with a fatal outcome despite the implementation of maximal modern therapy. However, strong prognostic factors can accurately predict whether children have "good" or "bad" at diagnosis, and clinical stage currently most significant clinically relevant factor. Therefore, for individual patient, proper staging paramount importance risk assessment selection optimal...
Gastrinomas are neuroendocrine tumors (NETs), usually located in the duodenum or pancreas, that secrete gastrin and cause a clinical syndrome known as Zollinger-Ellison (ZES). ZES is characterized by gastric acid hypersecretion resulting severe acid-related peptic disease (peptic ulcer disease, PUD; gastro-esophageal reflux GERD) [1,2,3] diarrhea. In this section ZES, due to both duodenal pancreatic gastrinomas, will be covered together because clinically they similar [2, 3]. Specific points...
Abstract In a multi-centre study strontium-89 was shown to be effective in relieving bone pain from prostatic carcinoma patients who had failed conventional therapies. Of 83 assessed at 3 months, following the administration of dose least 1.5 MBq/kg, 75% derived benefit and 22% became free. Symptomatic improvement usually occurred within 6 weeks continued for between 4 15 months (mean months). Based on estimation part this recommended is 150 MBq. Toxicity low, provided platelet levels were...
scintigraphy with 111 In-pentetreotide, published by the Society of Nuclear Medicine [1] .99m Tc-Depreotide (Neotect ) is another commercially available somatostatin analog that has been approved specifically for detection lung cancer in patients pulmonary nodules [2] .Because relatively high abdominal background and impossibility performing delayed imaging due to short half-life tracer, it less suited neuroendocrine tumors [3] .Somatostatin a regulatory peptide widely distributed human...
The aim of this single-site, open-label clinical trial was to determine the biodistribution, pharmacokinetics, absorbed doses, and safety from 2 sequential weight-based administrations (223)Ra-dichloride in patients with bone metastases due castration-refractory prostate cancer.
A qualitative assessment of conventional bone scintigraphy with 99mTc methylene diphosphonate is perceived as an insensitive method for monitoring the treatment response metastases, and we postulated that semi-quantitative 18F-fluoride positron emission tomography (PET) might serve a suitable alternative biomarker response. Five patients castrate-resistant prostate cancer metastases no known soft tissue disease received 100 kBq/kg radium-223 (223Ra)-chloride (Alpharadin) therapy at 0 6 weeks...
A robust method is required to standardise objective reporting of diagnostic 123I-mIBG images in neuroblastoma. Prerequisites for an appropriate system are low inter- and intra-observer error reproducibility across a broad disease spectrum. We present new method, developed tested SIOPEN by international expert panel. Patterns abnormal skeletal uptake were defined assigned numerical scores [0–6] based on extent within 12 body segments. Uptake intensity was excluded from the analysis. Data...
We report the safety, biodistribution, and internal radiation dosimetry, in humans with thyroid cancer, of <sup>18</sup>F-tetrafluoroborate (<sup>18</sup>F-TFB), a novel PET radioligand for imaging human sodium/iodide symporter (hNIS). <b>Methods:</b> Serial whole-body scans 5 subjects recently diagnosed cancer were acquired before surgery up to 4 h after injection 184 ± 15 MBq <sup>18</sup>F-TFB. Activity was determined whole blood, plasma, urine. Mean organ-absorbed doses effective...
aDepartment of Internal Medicine, Endocrine Unit, Uppsala University Hospital, Uppsala, Sweden; bDepartments Medicine and Endocrinological Metabolic Sciences, Genoa, Italy; cG. Genimatas Athens, Greece; dDepartment Surgery, Rigshospitalet, Copenhagen, Denmark; eNetherlands Cancer Centre, Amsterdam, The Netherlands; fDepartment Hepatology Gastroenterology, Campus Virchow-Klinikum, Charite-Universitatsmedizin Berlin, Germany
Despite its desirable half-life and low energy Auger electrons that travel further than for other radionuclides, 67Ga has been neglected as a therapeutic radionuclide. Here, is compared with electron emitter 111In potential Plasmid pBR322 studies allowed direct comparison between (1 MBq) in causing DNA damage, including the effect of chelators (EDTA DTPA) effects free radical scavenger (DMSO). The cytotoxicity internalized (by means delivery form oxine complexes) non-internalized was...
Phaeochromocytoma is initially imaged with computed tomography (CT) or magnetic resonance imaging (MRI) but functional commonly needed to assess disease activity, the presence of metastasis and response therapy. Traditionally, this done 123I -MIBG good sensitivity specificity. However, spatial resolution remains limited even SPECT. We aimed utility a new somatostatin analogue PET tracer, 68Ga-DOTATATE in management phaeochromocytoma.We retrospectively reviewed five patients malignant...