A5086888726- Neuroendocrine Tumor Research Advances
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Lung Cancer Research Studies
- Neuroblastoma Research and Treatments
- Helicobacter pylori-related gastroenterology studies
- Inflammatory Bowel Disease
- Monoclonal and Polyclonal Antibodies Research
- Crystallography and molecular interactions
- Gastrointestinal motility and disorders
- Escherichia coli research studies
- Glycosylation and Glycoproteins Research
- Metal complexes synthesis and properties
- Crystal structures of chemical compounds
- Pancreatic and Hepatic Oncology Research
- Neuropeptides and Animal Physiology
- Organometallic Complex Synthesis and Catalysis
- Coordination Chemistry and Organometallics
- Receptor Mechanisms and Signaling
- Viral gastroenteritis research and epidemiology
- Microscopic Colitis
- Adipose Tissue and Metabolism
- Pancreatic function and diabetes
- Vibrio bacteria research studies
- Ultrasound and Hyperthermia Applications
Karolinska Institutet
1994-2022
Norwegian University of Science and Technology
2008-2020
St Olav's University Hospital
2006-2020
Yale University
2008-2013
University of California, Davis
2006-2008
Chalmers University of Technology
1978-2005
Integrative Research Laboratories
1981-1985
University of Gothenburg
1978
Cancer Research Institute of the Slovak Academy of Sciences
1969
The National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) program has proven to be a significant resource in US neuroendocrine tumor (NET) epidemiology. Norway also holds robust detailed cancer registry: the Norwegian Registry of (NRC).SEER NET data were compared with corresponding NRC time period 1993 2004 determine whether there are differences epidemiology between United States.The SEER reported 17,312 2030 NETs, respectively. overall Caucasian incidence was 4.44,...
Background— The purpose of this study was to investigate whether rats dosed with serotonin develop changes similar those seen in human carcinoid heart disease. Methods and Results— Ten Sprague-Dawley were given injections subcutaneously once daily for 3 months; controls saline. A long-lasting hyperserotoninemia a >10-fold increase both platelet-poor plasma dialysate from the femoral muscles appeared. animals developed clinical signs such as flushing loose stools. After months, 6 10 had...
Mechanisms by which gut luminal content regulates secretion and motility are ill understood. We evaluated whether neuroendocrine enterochromaffin (EC) cells act as sensors for a wide variety of nutrients defined the secretory mechanisms this process. Pure (98-99%) FACS-sorted human EC neoplastic (KRJ-I) were studied. RT-PCR identified transcripts T2R1 (bitter), OR1G1 (class II olfactory) trace amine (TAR1) G protein-coupled receptors (GPCRs) transporters glutamine (SNAT1/2), glucose...
scintigraphy with 111 In-pentetreotide, published by the Society of Nuclear Medicine [1] .99m Tc-Depreotide (Neotect ) is another commercially available somatostatin analog that has been approved specifically for detection lung cancer in patients pulmonary nodules [2] .Because relatively high abdominal background and impossibility performing delayed imaging due to short half-life tracer, it less suited neuroendocrine tumors [3] .Somatostatin a regulatory peptide widely distributed human...
Complementary imaging modalities provide more information than either method alone can yield and we have developed a dual-mode probe for combined magnetic resonance (MR) positron emission tomography (PET) imaging. We PET/MRI active probes targeted to vascular inflammation present synthesis of (1) an aliphatic amine polystyrene bead (2) novel superparamagnetic iron oxide nanoparticle macrophages that were both coupled positron-emitting copper-64 isotopes. The groups the beads directly...
We have developed a new oral vaccine against enterotoxigenic Escherichia coli (ETEC), which is the most common cause of bacterial diarrhea in children developing countries and travelers.The was tested for safety immunogenicity alone together with double-mutant heat-labile toxin (dmLT) adjuvant double-blind, placebo-controlled Phase I study 129 Swedish adults. The consists four inactivated recombinant E. strains overexpressing major ETEC colonization factors (CFs) CFA/I, CS3, CS5, CS6 mixed...
Recent studies have proposed a role for serotonin and its transporter in regulation of bone cell function. In the present study, we examined vitro effects inhibitor fluoxetine "Prozac" on osteoblasts osteoclasts. Human mononuclear cells were differentiated into osteoclasts presence or fluoxetine. Both compounds affected total number as well resorption bell-shaped manner. RT-PCR human demonstrated several receptors, transporter, rate-limiting enzyme synthesis, tryptophan hydroxylase 1 (Tph1)....
Abstract Gut mucosal enterochromaffin (EC) cells are regarded as key regulators of intestinal motility and fluid secretion via serotonin (5HT), increased in numbers inflammation located close proximity to immune cells. We examined whether interleukin (IL)1β Escherichia coli lipopolysaccharide (LPS) induced EC cell 5HT release through Toll‐like/IL‐1 (TIL) receptor activation, nuclear factor kappa B (NFκB) mitogen‐activated protein kinase (MAPK) phosphorylation evaluated somatostatin could...
Neuroendocrine tumours (NETs) are increasing in both incidence and prevalence and, as a group, more prevalent than either gastric, pancreatic, oesophageal or hepatobiliary adenocarcinomas, any two of these cancers combined. Clinical awareness the protean intermittent symptoms NETs (eg, sweating, flushing, diarrhoea, bronchospasm) is critical for timely diagnosis; however, classical carcinoid syndrome relatively uncommon. The most useful diagnostic test gastrointestinal measurement plasma...
Serotonergic pathways in the central nervous system (CNS) are activated regulation of food intake and body weight. We hypothesized that adipocytes, like other cells mesenchymal origin, possess serotonin receptors thus could be regulated by peripherally circulating serotonin.In vivo studies: four Sprague-Dawley rats were given daily (5HT) injections subcutaneously (s.c., 25 mg/kg) for 5 days; controls received saline. In a long-term study, 12 s.c. 4 months, 10 Body weight was registered...
Microbubbles (MBs) are commonly used as injectable ultrasound contrast agent (UCA) in modern ultrasonography. Polymer-shelled UCAs present additional potentialities with respect to marketed lipid-shelled UCAs. They more robust; that is, they have longer shelf and circulation life, surface modifications quite easily accomplished obtain enhanced targeting local drug delivery. The next generation of will be required support not only ultrasound-based imaging methods but also other complementary...
The regenerating islet-derived (REG) gene family encodes a group of proteins highly expressed in several human pathologies, many which are associated with epithelial inflammation. All members, namely REG1A, REG1B, REG3A and REG4, closely related genomic sequence all part the c-type lectin superfamily. REGs during inflammatory bowel disease (IBD)-related colonic inflammation vivo expression pattern REG1A REG4 has been localised by using immunohistochemistry. However, function encoded is...
Background Rectal instillation of trinitrobenzene sulphonic acid (TNBS) in ethanol is an established model for inflammatory bowel disease (IBD). We aimed to 1) set up a TNBS-colitis protocol resulting endoscopic and histologic picture resembling IBD, 2) study the correlation between endoscopic, gene expression alterations at different time points after colitis induction, 3) compare rat human IBD mucosal transcriptomic data evaluate whether appropriate IBD. Methodology/Principal Findings Five...
Abstract Background and Aims Intestinal epithelial cells [IECs] secrete cytokines that recruit immune to the mucosa regulate responses drive inflammation in inflammatory bowel disease [IBD]. However, experiments patient-derived IEC models are still scarce. Here, we aimed investigate how innate immunity IEC-specific pattern recognition receptor [PRR] signalling can be involved an enhanced type I interferon [IFN] gene signature observed colon epithelium of patients with active IBD, a special...