A5018297789- Nanoparticle-Based Drug Delivery
- Ultrasound and Hyperthermia Applications
- Nanoplatforms for cancer theranostics
- Photoacoustic and Ultrasonic Imaging
- Traumatic Brain Injury and Neurovascular Disturbances
- bioluminescence and chemiluminescence research
- Atomic and Subatomic Physics Research
- Medical Imaging and Pathology Studies
- Dendrimers and Hyperbranched Polymers
- Advanced MRI Techniques and Applications
- Carbon Nanotubes in Composites
- Characterization and Applications of Magnetic Nanoparticles
- Hormonal Regulation and Hypertension
- Advanced biosensing and bioanalysis techniques
- Bone Tissue Engineering Materials
- Pharmacological Effects of Natural Compounds
- Erythrocyte Function and Pathophysiology
- Facial Trauma and Fracture Management
- Advanced Polymer Synthesis and Characterization
- Chemical and Physical Properties in Aqueous Solutions
- Hemostasis and retained surgical items
Karolinska Institutet
2013-2016
Karolinska University Hospital
2012-2014
Swedish Orphan Biovitrum (Sweden)
2004
Microbubbles (MBs) are commonly used as injectable ultrasound contrast agent (UCA) in modern ultrasonography. Polymer-shelled UCAs present additional potentialities with respect to marketed lipid-shelled UCAs. They more robust; that is, they have longer shelf and circulation life, surface modifications quite easily accomplished obtain enhanced targeting local drug delivery. The next generation of will be required support not only ultrasound-based imaging methods but also other complementary...
In the present study, we used multimodal imaging to investigate biodistribution in rats after intravenous administration of a new 99mTc-labeled delivery system consisting polymer-shelled microbubbles (MBs) functionalized with diethylenetriaminepentaacetic acid (DTPA), thiolated poly(methacrylic acid) (PMAA), chitosan, 1,4,7-triacyclononane-1,4,7-triacetic (NOTA), NOTA-super paramagnetic iron oxide nanoparticles (SPION), or DTPA-SPION.Examinations utilizing planar dynamic scintigraphy and...
Background: In the present investigation, we studied kinetics and biodistribution of a contrast agent consisting poly(vinyl alcohol) (PVA) microbubbles containing superparamagnetic iron oxide (SPION) trapped between PVA layers (SPION microbubbles). Methods: The biological fate SPION was determined in Sprague-Dawley rats after intravenous administration. Biodistribution elimination were using magnetic resonance imaging for period 6 weeks. sacrificed perfusion-fixated at different time points....
Multifunctional nanocarriers for controlled drug delivery, imaging of disease development and follow-up treatment efficacy are promising novel tools diagnosis treatment. In the current investigation, we present a multifunctional theranostic nanocarrier system anticancer delivery molecular imaging. Superparamagnetic iron oxide nanoparticles (SPIONs) as an MRI contrast agent busulphan model lipophilic antineoplastic drugs were encapsulated into poly (ethylene glycol)-co-poly (caprolactone)...
In the present study, we introduce a novel method for in vivo imaging of biodistribution single wall carbon nanotubes (SWNTs) labeled with recombinant thermo-stable Luciola cruciata luciferase (LcL). addition, highlight new application green fluorescent proteins which they are utilized as moieties SWNTs. Carbon show great positive potential compared to other drug nanocarriers respect loading capacity, cell internalization, and biodegradability. We have also studied effect binding mode...
Magnetic Resonance Imaging (MRI) is a noninvasive diagnostic method that provides information on morphological and physiological changes of the internal organs over time. measurements can be repeated same subject, thereby reducing inter-individual variability effects hence number subjects required. A potential MRI contrast agent consisting microbubbles embedded with superparamagnetic iron oxide nanoparticles (SPION) in shell (SPION MBs) was injected intravenously into rats to determine their...