A5079210929- Nuclear physics research studies
- Radiation Therapy and Dosimetry
- Quantum Chromodynamics and Particle Interactions
- Particle physics theoretical and experimental studies
- Radiation Detection and Scintillator Technologies
- Nuclear Physics and Applications
- Particle Detector Development and Performance
- High-Energy Particle Collisions Research
- Advanced Radiotherapy Techniques
- Atomic and Molecular Physics
- Astronomical and nuclear sciences
- Nuclear reactor physics and engineering
- Superconducting Materials and Applications
- Advanced X-ray and CT Imaging
- Medical Imaging Techniques and Applications
- Boron Compounds in Chemistry
- Dark Matter and Cosmic Phenomena
- Advanced NMR Techniques and Applications
- Gamma-ray bursts and supernovae
- Electron and X-Ray Spectroscopy Techniques
- Nanoparticle-Based Drug Delivery
- Radiation Shielding Materials Analysis
- Microwave Engineering and Waveguides
- Quantum, superfluid, helium dynamics
- Radiomics and Machine Learning in Medical Imaging
University of Groningen
2010-2019
Ghent University Hospital
2015
Zorginstituut Nederland
2008-2014
Institute of Physics
2003-2013
Jagiellonian University
2013
Delft University of Technology
2011-2012
University of Silesia in Katowice
2003-2011
Campbell Collaboration
2010
The use of nanoparticles to enhance the effect radiation-based cancer treatments is a growing field study and recently, even nanoparticle-induced improvement proton therapy performance has been investigated. Aiming at clinical implementation this approach, it essential characterize mechanisms underlying synergistic effects combined with irradiation. In study, we investigated platinum- gadolinium-based on nanoscale damage induced by beam therapeutically relevant energy (150 MeV) using plasmid...
High-precision cross-section data of the deuteron-proton breakup reaction at 130 MeV are presented for 72 kinematically complete configurations. The cover a large region available phase space, divided into systematic grid kinematical variables. They compared with theoretical predictions, in which full dynamics three-nucleon (3N) system is obtained three different ways: realistic nucleon-nucleon (NN) potentials combined model 3N forces (3NF's) or an effective 3NF resulting from explicit...
Therapeutic proton and heavier ion beams generate prompt gamma photons that may escape from the patient. In principle, this allows for real-time, in situ monitoring of treatment delivery, particular, hadron range within patient, by imaging emitted rays. Unfortunately, neutrons simultaneously created with create a background obscure signal. To enhance accuracy dose verification imaging, we therefore propose time-of-flight (TOF) technique to reject neutron background, involving shifting time...
The only method for in vivo dose delivery verification proton beam radiotherapy clinical use today is positron emission tomography (PET) of the emitters produced patient during irradiation. PET imaging while on (so called beam-on PET) an attractive option, providing largest number counts, least biological washout and fastest feedback. In this implementation, all nuclides, independent their half-life, will contribute. As a first step towards assessing relevance short-lived nuclides (half-life...
High precision cross-section data of the deuteron-proton breakup reaction at 130 MeV deuteron energy are compared with theoretical predictions obtained a coupled-channel extension CD Bonn potential virtual Delta-isobar excitation, without and inclusion long-range Coulomb force. The effect is studied on basis set, extended in this work to about 1500 points by including geometries characterized small polar angles two protons. experimental clearly prefer interaction included. strongest effects...
High-precision data for vector and tensor analyzing powers the $^{1}\mathrm{H}$$(\mathrm{dP\vec},\mathit{pp})n$ reaction at a 130-MeV deuteron beam energy have been measured over large part of phase space. Theoretical predictions based on various approaches to describe three nucleon ($3N$) system reproduce very well power no three-nucleon force effect is observed these observables. Tensor are also reproduced by calculations in almost whole studied region, but locally certain discrepancies...
Observables in elastic proton-deuteron scattering are sensitive probes of the nucleon-nucleon interaction and three-nucleon force effects. The present experimental database for this reaction is large, but contains a large discrepancy between data sets differential cross section taken at 135 MeV/nucleon by two research groups. This article reviews background problem presents new Kernfysisch Versneller Instituute (KVI). Differential sections analyzing powers...
High precision vector and tensor analyzing power data of the deuteron-proton elastic scattering at 130 MeV deuteron beam energy have been measured in a large range angles. They are compared with theoretical predictions obtained various approaches: realistic potentials for pure $\mathit{NN}$ interactions, inclusion three-nucleon force, framework chiral perturbation theory. All calculations describe roughly main features distributions, but none them can reproduce all their details. This...
In 2016 and 2017, the 8th 9th 4D treatment planning workshop took place in Groningen (the Netherlands) Vienna (Austria), respectively. This annual brings together international experts to discuss research, advances clinical implementation as well problems challenges planning, mainly spot scanned proton therapy. last two years several aspects like beam delivery, Monte Carlo simulations, motion modeling monitoring, QA phantoms imaging were thoroughly discussed.This report provides an overview...
The measurement of exclusive deuteron-proton breakup for kinematics covering a large fraction the available phase space has been performed using $130\phantom{\rule{0.3em}{0ex}}\text{MeV}$ deuteron beam. High precision fivefold cross section data in 38 kinematical configurations have compared to predictions modern nuclear forces. To this aim three-nucleon $(3N)$ Faddeev equations solved rigorously nucleon-nucleon (NN) potentials AV18, charge-dependent Bonn, Nijm I, and II alone, combining...
High-precision measurements of the proton-deuteron elastic and break-up reaction have been performed in past at KVI elsewhere with aim to study three-nucleon force (3NF) effects. In present work, we explored 3NF effects scattering process by performing a measurement vector analyzing powers differential cross sections using 135 MeV polarized-proton beam impinging on liquid-deuterium target. For this study, used new experimental setup, Big Instrument for Nuclear-polarization Analysis, BINA,...
Set of vector analyzing power data the d⃗p elastic scattering and 1H(d⃗,pp)n breakup reactions at 130-MeV deuteron beam energy has been measured in domain very forward polar angles. The results are compared with theoretical predictions originating from various approaches: realistic nucleon-nucleon (NN) potentials NN combined a three-nucleon force (3NF) model based on ChPT framework. In case process, none calculations reveal sensitivity to any dynamical effects such as 3NF or Coulomb...
A major weakness of ion beam therapy is the lack tools for verifying particle range in clinical routine. The application Compton camera concept imaging prompt gamma rays, a by-product irradiation correlated to dose distribution, promising approach assessment and even three-dimensional vivo dosimetry.
In an experiment with a 65 MeV/nucleon polarized deuteron beam on liquid-deuterium target at KVI, several multi-body final states in deuteron-deuteron scattering were identified. For these measurements, unique and advanced detection system, called BINA, was utilized. We demonstrate the feasibility of measuring vector tensor polarization observables break-up reaction leading to three-body final-state. The determined high precision nearly background-free experiment. analysis procedure some...
High-quality vector analyzing power data for the 1 H(d,pp)n breakup reaction and elastic scattering at 100MeV beam energy have been measured in a large part of phase space these processes. The results are compared to theoretical predictions obtained using charge-dependent Bonn potential alone or combined with three-nucleon force TM99 as well calculations coupled-channel approach, without inclusion Coulomb interaction. In studied observables, effects 3NF almost absent. pairwise NN...
Precise monitoring of the particle range inside body, preferably in real-time, is a primary interest quality assurance therapy. Prompt-gamma (PG) detection aims at this task, but such system technically challenging to implement. For mechanically collimated PG detection, neutron-induced background radiation originating collimator material major issue. We study by Monte-Carlo simulations (Geant4), influence different designs and their geometric parameters - as distance source, size septa...
We have studied spin observables in the three-body break-up reaction deuteron–deuteron scattering phase-space regime that corresponds to quasi-free deuteron–proton process with neutron as spectator. The data are compared measurements of elastic and state-of-the-art Faddeev calculations. results for iT11 T22 agree very well previously published elastic-scattering data. A significant discrepancy is found T20, which could point a break-down assumption.
The development of a proton radiography system to improve the imaging patients in beam therapy is described. comprises gridpix based time projection chambers, which are on Timepix chip designed by Medipix collaboration, for tracking protons. This type detector was chosen have minimal impact actual determination tracks detectors. To determine residual energy protons, BaF 2 crystal with photomultiplier tube used. We present data taken feasibility experiment phantoms that represent tissue...
We successfully identified several multibody final states in deuteron-deuteron scattering at 65 MeV/nucleon KVI using a unique and advanced detection system called BINA. This facility enabled us to perform cross sections polarization measurements with an improved statistical systematic precision. The analysis procedure part of the results three-body break-up channel are presented.