A5103198087- Particle physics theoretical and experimental studies
- Particle Detector Development and Performance
- Radiation Therapy and Dosimetry
- Advanced Radiotherapy Techniques
- Dark Matter and Cosmic Phenomena
- High-Energy Particle Collisions Research
- Radiation Effects in Electronics
- Radiation Detection and Scintillator Technologies
- Neutrino Physics Research
- Astrophysics and Cosmic Phenomena
- Big Data Technologies and Applications
- Scientific Computing and Data Management
- Quantum Chromodynamics and Particle Interactions
- Computational Physics and Python Applications
- Nuclear Physics and Applications
- Particle Accelerators and Free-Electron Lasers
- Particle accelerators and beam dynamics
- Advanced Data Storage Technologies
- Distributed and Parallel Computing Systems
- Data Visualization and Analytics
- Geomagnetism and Paleomagnetism Studies
- Boron Compounds in Chemistry
- Astronomical Observations and Instrumentation
- Inertial Sensor and Navigation
Paul Scherrer Institute
2014-2024
University Hospital of Zurich
2018
RWTH Aachen University
2008-2010
Institute of High Energy Physics
2010
There are several general recommendations for quality assurance (QA) measures, which have to be performed at proton therapy centres. However, almost each centre uses a different system. In particular, there is no standard procedure centres employing pencil beam scanning and applies specific QA program. Gantry 2 an operating system was developed PSI relies on the most advanced technological innovations. We comprehensive daily program in order verify main characteristics assure functionality...
In 2016 and 2017, the 8th 9th 4D treatment planning workshop took place in Groningen (the Netherlands) Vienna (Austria), respectively. This annual brings together international experts to discuss research, advances clinical implementation as well problems challenges planning, mainly spot scanned proton therapy. last two years several aspects like beam delivery, Monte Carlo simulations, motion modeling monitoring, QA phantoms imaging were thoroughly discussed.This report provides an overview...
An on-line beam position monitoring and regular stability tests are of utmost importance for the Quality Assurance (QA) patient treatment at any particle therapy facility. The Gantry 2 Paul Scherrer Institute uses a strip ionization chamber verification. design placed in front allows small penumbra order to achieve high-quality lateral delivery. error 1 mm plane (plane perpendicular direction) can result dose inhomogeneity more than 5%. Therefore goal commissioning was reach sub-millimeter...
Objective.In pencil beam scanning particle therapy, a short treatment delivery time is paramount for the efficient of moving targets with motion mitigation techniques (such as breath-hold, rescanning, and gating). Energy spot position change are limiting factors in reducing time. In this study, we designed universal dynamic energy modulator (ridge filter, RF) to broaden Bragg peak, reduce number energies spots required cover target volume, thus lowering time.Approach. Our RF unit comprises...
Fast energy switching is of fundamental importance to implement motion mitigation techniques in pencil beam scanning proton therapy, allowing efficient irradiation and high patient throughput. However, depending on magnet design, when between different layers, eddy currents arise the bending magnets' yoke, damping speed magnetic field change lengthening settling time field. In a therapy gantry, this can cause temporary displacement trajectory consequently an incorrect position direction,...
We present a procedure for reconstructing particle cascades from event data measured in high energy physics experiment. For evaluating the hypothesis of specific process causing observed data, all possible reconstruction versions scattering are constructed final state objects. describe as well examples processes different complexity studied at hadron-hadron colliders. estimate performance by 20 microseconds per reconstructed decay vertex, and 0.6 kByte trees.
VISPA is a development environment for high energy physics analyses which enables physicists to combine graphical and textual work. A analysis cycle consists of prototyping, performing, verifying the analysis. The main feature multipurpose window visual steering steps, creation templates, browsing event data at different steps an follows experiment-independent approach incorporates various tools controlling required in typical Connection frameworks experiments achieved by using types...
VISPA is a novel development environment for high energy physics analyses, based on combination of graphical and textual steering. The primary aim to support physicists in prototyping, performing, verifying data analysis any complexity. We present example screenshots, describe the underlying software concepts.
At the Paul Scherrer Institute (PSI) in Switzerland, cancer patients are treated with protons. The PSI Gantries work Pencil Beam Scanning (PBS) technology. For beam profile characterization, a new 2-D planar pixel detector based on Printed Circuit Board technology was developed. main challenge of design limited amount 256 readout channels while several thousands signals had to be processed. With PBS, only few pixels will hit by proton and give significant signal, most them not capture any...
Gantry 2 at PSI is a Pencil Beam Scanning (PBS) cyclotron-based proton therapy system. The main principle of PBS sequential dose-spot delivery to all positions (spots) within the tumour. This technique proved be an effective treatment method for static tumours, however mobile targets (e.g. lung or liver) organ motion interferes with beam lowering quality. A common mitigate effects re-scan volume multiple times. One distinguishes between iso-layered re-scanning (LR) where re-scans are...
Abstract Sub-millimetre precision is a crucial criterion for beam delivery in Pencil Beam Scanning (PBS) proton therapy. Nowadays, most of the therapy systems use PBS technique where single beams with regulated number protons are delivered sequentially to different locations within target. energy defines depth target and scanner magnets deflect desired lateral position. The PSI Gantry 2 was among first gantries technique. Available clinical energies ranging from 70 MeV 230 achieved by...
Objective.The treatment of mobile tumours using Pencil Beam Scanning (PBS) has become more prevalent in the last decade. However, to achieve same beam delivery quality as for static tumours, treatments have be combined with motion mitigation techniques, not limited but including, breath hold, gating and re-scanning, which typically prolong time. In this article we present a novel method bi-directional energy modulation demonstrate our initial experience improvement efficiency. Approach.At...
Gantry 2 at PSI is a Pencil Beam Scanning (PBS) cyclotron-based proton therapy system. The main principle of PBS sequential dose-spot delivery to all positions (spots) within the tumour. This technique proved be an effective treatment method for static tumours, however mobile targets (e.g. lung or liver) organ motion interferes with beam lowering quality. A common mitigate effects re-scan volume multiple times. One distinguishes between iso-layered re-scanning (LR) where re-scans are...
S5363rd ESTRO Forum 2015 the low penetration of kV x-rays limits their useful depth range.An interesting solution is to bring x-ray tube close GNP-loaded tumors.But this can result in non-uniform tumor dose distributions.Although a sharp falloff brachytherapy, it may not be desirable for thick tumors.Here, DE was investigated with additional aim creating uniformity, idea being that using different concentrations GNP within potentially as means compensating falloff.Materials and Methods: A...
VISPA is a novel graphical development environment for physics analysis, following an experiment-independent approach.It introduces new way of steering data combining and textual programming.The purpose to speed up the design facilitate its control.As software basis C++ toolkit Physics eXtension Library (PXL) used which successor project Analysis eXpert (PAX) package.The most prominent features this are management relations, copyable container holding different aspects events, ability store...
Abstract Spot-scanning is a highly dynamic treatment method in proton therapy, tailored to each tumor shape individually. By superimposing many single spots all three spatial axes, prescribed dose applied the volume. To minimize inhomogeneity across this volume, tight constraints on beam position accuracy apply: for below 1%, longitudinal of order 1 mm necessary, whereas lateral plane, needs be roughly one magnitude better. Longitudinal control achieved through selecting energy; laterally,...
VISPA is a novel development environment for high energy physics analyses, based on combination of graphical and textual steering. The primary aim to support physicists in prototyping, performing, verifying data analysis any complexity. We present example screenshots, describe the underlying software concepts.
Purpose In PBS particle therapy, short treatment delivery time is paramount for the efficient of moving targets with motion mitigation techniques (such as breath-hold, rescanning, and gating). Energy spot position change are limiting factors in reducing time. this study, we designed a universal dynamic energy modulator (ridge filter, RF) to broaden Bragg peak, reduce number energies spots required cover target volume, thus lowering Methods Our RF unit comprises two identical RFs placed just...