A5074995586- Particle Detector Development and Performance
- Radiation Detection and Scintillator Technologies
- Nuclear Physics and Applications
- Radiation Therapy and Dosimetry
- Medical Imaging Techniques and Applications
- CCD and CMOS Imaging Sensors
- Advanced X-ray and CT Imaging
- Bone fractures and treatments
- Hip disorders and treatments
- Neurogenetic and Muscular Disorders Research
- Orthopedic Infections and Treatments
- Orthopaedic implants and arthroplasty
- Orthopedic Surgery and Rehabilitation
- Mass Spectrometry Techniques and Applications
- Advanced Radiotherapy Techniques
- Congenital limb and hand anomalies
- Hip and Femur Fractures
- Total Knee Arthroplasty Outcomes
- Ion-surface interactions and analysis
- Radiation Dose and Imaging
- Advanced Semiconductor Detectors and Materials
- Shoulder and Clavicle Injuries
- Child and Adolescent Health
- Musculoskeletal Disorders and Rehabilitation
- Foot and Ankle Surgery
National Institute for Subatomic Physics
1999-2017
Dialyse Centrum Groningen
2017
Cancer Research Center
2017
Centro de Investigación del Cáncer
2017
National Aeronautics and Space Administration
2015
Czech Academy of Sciences, Institute of Physics
2011
Czech Academy of Sciences
2011
Wilhelmina Children's Hospital
2010
University of Groningen
1982-1989
We demonstrate a coincidence velocity map imaging apparatus equipped with novel time-stamping fast optical camera, Tpx3Cam, whose high sensitivity and nanosecond timing resolution allow for simultaneous position time-of-flight detection. This single detector design is simple, flexible, capable of highly differential measurements. show detailed characterization the camera its application in strong field ionization experiments.
Summary: A method for the measurement of hip instability index and femoral acetabular torsion using computerized tomography is presented. The influence different positions was studied.
In mass spectrometry imaging, spatial resolution is pushed to its limits with the use of ion microscope spectrometric imaging systems. An magnifies and then projects original distribution ions from a sample surface onto position-sensitive detector, while retaining time-of-flight separation capabilities. Here, new type detector based on chevron microchannel plate stack in combination 512 × complementary metal-oxide-semiconductor pixel coupled an microscope. Spatial resolving power better than...
The realisation of the Timepix3 chip opened way for new opportunities in research areas such as particle tracking with both semiconductor sensors and gas filled time projection chambers, electron microscopy imaging mass spectrometry.
Highly parallel, active pixel detectors enable novel detection capabilities for large biomolecules in time-of-flight (TOF) based mass spectrometry imaging (MSI). In this work, a 512 × pixel, bare Timepix assembly combined with chevron microchannel plates (MCP) captures time-resolved images of several m/z species single measurement. Mass-resolved ion from measurements peptide and protein standards demonstrate the capability to return both mass-spectral localization information biologically...
The SPIDR (Speedy PIxel Detector Readout) system is a flexible general-purpose readout platform that can be easily adapted to test and characterize new existing detector ASICs. It originally designed for the of pixel ASICs from Medipix/Timepix family, but other types or front-end circuits read out as well. consists an FPGA board with memory various communication interfaces, firmware, CPU subsystem API library on PC . firmware by re-using IP blocks. available blocks include UDP packet...
- A delegation of 6 pediatric orthopedic surgeons from the Dutch Orthopedic Association (NOV) and 2 members board Parents' for children with clubfoot created guideline "The diagnosis treatment primary idiopathic clubfeet" between April 2011 February 2014. The development was supported by a professional methodologist Knowledge Institute Medical Specialists. This evidence-based process new unique, in sense that initiated parents' association. is first official orthopedics Netherlands, to our...
A prerequisite for the development of congenital dislocation hip is ligamentous laxity hip-joint, which demonstrable shortly after birth when can be easily dislocated and reduced. This situation described as dislocatable hip. Ligamentous naturally tends to disappear, 90% all hips in fact stabilize spontaneously. No develops unless an exogenous factor involved. In infants born breech presentation hyperextension knees with resulting increased tension hamstrings plays a role. During or birth,...
Short-term follow-up studies show good results in foot function, after surgical treatment of idiopathic clubfeet. Long-term are rare and probably represent a mixture experience different treating orthopedic surgeons. The purpose this study is to present the long-term posteromedial release (PMR) congenital clubfoot 1 surgeon.Thirty-eight patients with 58 clubfeet had an la carte PMRe, performed by experienced pediatric surgeon before age 2 years. This group mean 16 years (range 13 24 years)....
We demonstrate the capabilities of a highly parallel, active pixel detector for large-area, mass spectrometric imaging biological tissue sections. A bare Timepix assembly (512x512 pixels) is combined with chevron microchannel plates on an ion microscope matrix-assisted laser desorption time-of-flight spectrometer (MALDI TOF-MS). The registers position- and time-resolved images multiple m/z species in every measurement frame. prove applicability detection system to bio-molecular spectrometry...
The implementation of the Timepix complementary metal oxide semiconductor pixel detector in velocity map slice imaging is presented. This new approach eliminates need for gating detector. In time-of-flight mode, returns impact position and charged particles with 12.5 ns resolution a dynamic range about 100 μs. combination microchannel plate additionally allows high spatial information via center-of-mass centroiding. Here, was applied to study photodissociation NO(2) at 452 nm. energy...
When a childhood fracture of the proximal tibial metaphysis with valgus dislocation is not anatomically reduced, deformity comparable angulation seen on accident X-ray develops within few weeks.The tibia shows neither exacerbation nor regression, but in number cases correction mechanical axis occurs distal epiphyseal plate.
A 300 μm thick thin p-on-n silicon sensor was connected to an energy sensitive pixel readout ASIC and exposed a beam of highly energetic charged particles. By exploiting the spectral information fine segmentation detector, we were able measure evolution transverse profile charge carriers cloud in as function drift distance from point generation. The result does not rely on model assumptions or electric field calculations. data are also used validate numerical simulations predict detector...
The development of a proton radiography system to improve the imaging patients in beam therapy is described. comprises gridpix based time projection chambers, which are on Timepix chip designed by Medipix collaboration, for tracking protons. This type detector was chosen have minimal impact actual determination tracks detectors. To determine residual energy protons, BaF 2 crystal with photomultiplier tube used. We present data taken feasibility experiment phantoms that represent tissue...
Measurements are shown of GeV pions and muons in two 300µm thick, Si Medipix pixel detector assemblies that stacked on top each other, with a 25µm thick brass foil between.In such radiation imaging semiconductor matrix large number pixels along the particle trail, one can determine local space vectors for trajectory instead points.This improves pattern recognition track reconstruction, especially crowded environment.Stacking sensor planes is essential resolving directional ambiguities.Signal...
Some X-ray imaging applications demand sensitive areas exceeding the active area of a single sensor. This requires seamless tessellation multiple detector modules with edgeless sensors. Our research is aimed at minimising insensitive periphery that isolates from edge. Reduction edge-defect induced charge injection, caused by deleterious effects dicing, an important step. We report on electrical characterisation 300 μm thick silicon p+-ν-n+ diodes, diced using deep reactive ion etching....
A prototype computerized tomography (CT) setup has been recently built at Nikhef in order to exploit the material resolved capabilities of Medipix based detectors X-ray imaging. The CT scanner contains a Hamamatsu 90 kVp microfocus tube and an entirely remotely controllable sample alignment system. complete is fully integrated with detector operation software. Moreover 120 frames/s RelaxD readout system [1] allows real time imaging fast moving samples.
We study the influence of active edges on response edge pixels by comparing simulations electrostatic-potential distribution to position-defined measurements energy deposition. A laser setup was used measure edge-pixel function and shows sensitive is only about 2 μm from physical edge. 3D reconstruction tracks high-energy pions muons, produced at SPS H6 test beam facility CERN, enabled relate deposition particle's interaction depth. clear correlation observed between simulated electric-field...
Imaging technologies play a key role in many branches of science, especially biology and medicine. They provide an invaluable insight into both internal structure processes within broad range samples. There are techniques that allow one to obtain images object. Different based on the analysis particular sample property by means dedicated imaging system, as such, each modality provides researcher with different information. The use multimodal (imaging several techniques) can additional...
The quality of cancer treatment with protons critically depends on an accurate prediction the proton stopping powers for tissues traversed by protons. Today, planning in radiotherapy is based power calculations from densities X-ray Computed Tomography (CT) images. This causes systematic uncertainties calculated range a patient typically 3–4%, but can become even 10% bone regions [1,2,3,4,5,6,7,8]. may lead to no dose parts tumor and too high healthy [1]. A direct measurement high-energy will...
In view of applications in X-ray spectral computed tomography, we determine the energy response function a 300 μm thick silicon pixel detector, read out by Timepix ASIC, for wide range energies, using synchrotron radiation 5-32.5 keV.