A5074470185- Laser-Matter Interactions and Applications
- Mass Spectrometry Techniques and Applications
- Spectroscopy and Quantum Chemical Studies
- Advanced Chemical Physics Studies
- Atomic and Molecular Physics
- Laser-Plasma Interactions and Diagnostics
- Photonic and Optical Devices
- Atomic and Subatomic Physics Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Myasthenia Gravis and Thymoma
- Semiconductor materials and devices
- Advancements in Semiconductor Devices and Circuit Design
- Lung Cancer Diagnosis and Treatment
- Photonic Crystals and Applications
- Photocathodes and Microchannel Plates
- Analog and Mixed-Signal Circuit Design
- Tracheal and airway disorders
- Semiconductor Lasers and Optical Devices
- Ion-surface interactions and analysis
- Semiconductor Quantum Structures and Devices
- Spectroscopy Techniques in Biomedical and Chemical Research
- Cancer-related Molecular Pathways
- Radiation Detection and Scintillator Technologies
- Silicon Carbide Semiconductor Technologies
- Advancements in PLL and VCO Technologies
SLAC National Accelerator Laboratory
2024-2025
Stanford University
2025
Stony Brook University
2017-2024
Jiujiang First People's Hospital
2024
Linkou Chang Gung Memorial Hospital
2017-2024
Chang Gung University
2002-2024
Union Hospital
2023
Huazhong University of Science and Technology
2021-2023
Wuhan Union Hospital
2021-2022
Chang Gung Memorial Hospital
2016-2019
Pediatric obstructive sleep apnea (OSA) is associated with chronic systemic inflammation and cognitive impairments. This study aimed to investigate the status of proinflammatory cytokines, particularly interleukin 17 (IL-17) 23 (IL-23) cognition in pediatric OSA. Controls OSA children participated study. Exclusion criteria were adenotonsillectomy, heart, neurological severe psychiatric diseases, craniofacial syndromes, obesity. Polysomnogram was followed by serum testing for inflammatory...
We demonstrate a coincidence velocity map imaging apparatus equipped with novel time-stamping fast optical camera, Tpx3Cam, whose high sensitivity and nanosecond timing resolution allow for simultaneous position time-of-flight detection. This single detector design is simple, flexible, capable of highly differential measurements. show detailed characterization the camera its application in strong field ionization experiments.
We extend covariance velocity map ion imaging to four particles, establishing cumulant mapping and allowing for measurements that provide insights usually associated with coincidence detection, but at much higher count rates. Without correction, a fourfold analysis is contaminated by the pairwise correlations of uncorrelated events, we have addressed this calculation full cumulant, which subtracts correlations. demonstrate approach on four-body breakup formaldehyde following strong field...
We describe the structural optimization of a hit compound, 1-(4-(1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)phenyl)-3-(3-methoxyphenyl)urea (1), which exhibits inhibitory activity but low potency against FLT3 and VEGFR2. A series pyrazolo[3,4-d]pyrimidine derivatives were synthesized, structure–activity relationship analysis using cell- transgenic-zebrafish-based assays led to discovery number compounds that exhibited both high FLT3-driven human acute myeloid leukemia (AML) MV4-11 cells...
Filming atomic motion within molecules is an active pursuit of molecular physics and quantum chemistry. A promising method laser-induced Coulomb Explosion Imaging (CEI) where a laser pulse rapidly ionizes many electrons from molecule, causing the remaining ions to undergo repulsion. The ion momenta are used reconstruct geometry which tracked over time (i.e., filmed) by ionizing at adjustable delay with respect start interatomic motion. Results distorted, however, ultrafast during pulse. We...
We compare trajectory-surface-hopping (TSH) calculations of the dissociation quadruply charged formaldehyde molecules with basic classical assuming Coulomb repulsion between singly atoms. The TSH show very different dynamics from calculations, illustrating that point charges does not accurately describe dynamics. By comparing covariance measurements, we see much better agreement experiments and evidence for production multiple electronic states tetracation via strong-field ionization.
Semiheavy water (HOD) is one of the simplest molecules in which bonds are labeled by isotope. We demonstrate that a pair intense few-femtosecond infrared laser pulses can be used to selectively tunnel ionize along two bonds. The first pulse doubly ionizes HOD, inducing rapid bond stretching and unbending. Femtoseconds later, second arrives further ionization enhanced OH bond. These conclusions arise from 3D time-resolved measurements <a:math...
We have developed new methods for the fabrication of high quality two-dimensional (2D) and three-dimensional (3D) photonic crystals. These techniques involve anisotropic etching steam oxidation AlAs mask layers. made manufacturable 2D crystals with aspect ratios use as micropolarizers measured extinction larger than 800 to 1 between TE TM modes transmitted through these structures. The Al2O3 technique also allows us fabricate 3D structures up six repeating layers in depth over 90%...
Radiocontrast-induced nephropathy (RIN) is one of the leading causes hospital-acquired acute kidney injury (AKI). The clinical strategies currently available for prevention RIN are insufficient. In this study, we aimed to determine whether resveratrol, a polyphenol phytoalexin, can be used prevent RIN. For purpose, in vitro experiments were performed using human renal proximal tubule epithelial cell line (HK-2 cells). Following treatment 48 h, highly toxic radiocontrast agent, ioxitalamate,...
ALTHOUGH various methods of neutralization have been employed for several years in vacuum-tube circuits,1 the unilateralization technique was introduced only recently. This is based on a study linear, active, four-terminal network theory, which has become increasingly important design transistor circuitry. Although neutralized circuits are usually treated as conventional balanced-bridge circuits, they can be analyzed more systematically problems. paper analyzes both and circuitry by means...
The combination of computer simulations and two powerful experimental methods for following molecular change on femtosecond timescales offers an unprecedented view how a photoexcited molecule breaks apart.
We demonstrate three-dimensional velocity map imaging of low energy electrons using a TPX3CAM, where the momentum information [px, py, pz] is encoded in position and timing [x, y, t] hits on camera sensor. make use sensor for y] constant fraction discriminator fast time to digital converter information. illustrate capabilities our apparatus by presenting above threshold ionization measurements xenon, which produces well defined structures resolved photoelectron yield.
Since their inception, velocity map imaging (VMI) techniques have received continued interest in expansion from 2D to 3D momentum measurements through either reconstructive or direct methods. Recently, much work has been devoted the latter of these by relating electron time-of-flight (TOF) third component. The challenge is having a timing resolution sufficient resolve structure narrow (<10 ns) TOF spread. Here, we build upon VMI lens design and measurement using plano-convex thick-lens...
Despite the recent introduction of technologically advanced single-port (SP) robotic systems, their use in field thoracic surgery has been rarely explored. Here, we report our preclinical experience concerning SP using da Vinci® system. The system was used to perform subcostal anatomical lung resection and subxiphoid thymectomy three cadavers. operative settings that best met surgeon’s requirements for each were also determined. Four resections two thymectomies completed. While both...
We describe the nanofabrication of first three-dimensional (3-d) photonic crystals with a forbidden bandgap lying in near infrared region electromagnetic spectrum, 1.1 μm < λ 1.5 μm, just beyond electronic band-edge GaAs. fabricated these structures by chemically assisted ion beam etching through triangular hole array mask, defined electron lithography on The 3-d was spectrally tuned 2-d lithographic control spatial periodicity. Optical transmission spectra were generally good agreement...
Abstract FLT3 has been identified as a valid target for the treatment of acute myeloid leukemia (AML) and some inhibitors have shown very good efficacy in treating AML clinical trials. Nevertheless, recent studies indicated that relapse drug resistance are still difficult to avoid stem cells (LSCs) considered one most important contributors. Here, we report characterization SKLB-677, new inhibitor developed by us recently. SKLB-677 exhibits low nanomolar potency biochemical cellular assays....
The angle-dependent single ionization of carbon dioxide by linearly and circularly polarized pulses is investigated experimentally. authors show that delay-dependent ion-momentum measurements from rotational wave packets can be used to test the validity axial recoil approximation.
Polyatomic molecules in strong laser fields can undergo substantial nuclear motion within tens of femtoseconds. Ion imaging methods based on dissociation or Coulomb explosion therefore have difficulty faithfully recording the geometry dependence field ionization that initiates process. Here we compare strong-field double and subsequent water (both H$_2$O D$_2$O) 10-fs 40-fs 800-nm pulses. We find pulses turn off before internuclear occurs, whereas rapid take place during process for The...
We investigate the role of nuclear motion and strong-field-induced electronic couplings during double ionization deuterated water using momentum-resolved coincidence spectroscopy. By examining three-body dicationic dissociation channel, ${\mathrm{D}}^{+}/{\mathrm{D}}^{+}/\mathrm{O}$, for both few- multicycle laser pulses, strong evidence intrapulse dynamics is observed. The extracted angle- energy-resolved yields are compared to classical trajectory simulations occurring from different...
We demonstrate the applicability of covariance analysis to three-dimensional velocity-map imaging experiments using a fast time stamping detector. Studying photofragmentation strong-field doubly ionized D2O molecules, we show that combining high count rate measurements with yields same level information typically limited "gold standard" true, low coincidence experiments, when averaging over large ensemble events. This increases effective data acquisition by approximately 2 orders magnitude,...
We present momentum-resolved coincidence measurements of strong-field single and double ionization deuterated water $({\mathrm{D}}_{2}\mathrm{O})$ using intense few-cycle laser pulses. measure the vector momentum electrons ions resulting from laser-molecule interaction. This enables us to photoelectron spectrum for in with fragment having different momenta, which can be related final states cation dication. The spectra ion momenta show striking differences, interpreted terms removal...
We present momentum resolved covariance measurements of entangled electronic-nuclear wave packets created and probed with octave spanning phaselocked ultrafast pulses. launch vibrational on multiple electronic states via multiphoton absorption, probe these strong field double ionization using a second pulse. Momentum mapping the fragment ions highlights nuclear motion, while yield as function relative phase between pump pulses highlight coherence. The combined allow us to directly visualize...
Abstract Objective To develop a prosthesis‐free medialization laryngoplasty for the treatment of glottal incompetence. Study Design Twenty‐two consecutive patients with incompetence underwent vocal fold using new paramedian approach to arytenoid adduction and/or strap muscle transposition. Methods Under local anesthesia, thyroid lamina on involved side was parasagittally separated 5 mm off midline. The inner perichondrium carefully freed from overlying cartilage. After dividing thyrohyoid...
This paper presents a single BCD technology platform with high performance power devices at wide range of operating voltages. The offers 6 V to 70 LDMOS devices. All offer best-in-class specific on-resistance 20 40 % lower than that the state-of-the-art IC-based and robustness better square SOA (safe-operating-area). Fully isolated devices, in which independent bias is capable for circuit flexibility, demonstrate superior (e.g. 11.9 mΩ-mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Hepatocellular carcinoma (HCC) is a serious life-threatening malignant disease of liver. Molecular targeted therapies are considered promising strategy for the treatment HCC. Sorafenib first, and so far only drug approved by US Food Drug Administration (FDA) clinical therapy Despite being effective in some HCC patients, demerits sorafenib HCC, such as modest survival benefits, resistance, have also been reported, which highlights unmet medical need among patients with Here, we report novel...