A5020034508- Hip disorders and treatments
- Bone fractures and treatments
- Connective tissue disorders research
- Orthopaedic implants and arthroplasty
- Neurogenetic and Muscular Disorders Research
- Bone health and osteoporosis research
- Shoulder Injury and Treatment
- Orthopedic Infections and Treatments
- Total Knee Arthroplasty Outcomes
- Healthcare Policy and Management
- Lysosomal Storage Disorders Research
- Advanced X-ray and CT Imaging
- Hip and Femur Fractures
- Bone and Dental Protein Studies
- Sarcoma Diagnosis and Treatment
- Osteoarthritis Treatment and Mechanisms
- Bone Tissue Engineering Materials
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Orthopedic Surgery and Rehabilitation
- Child and Adolescent Health
- Shoulder and Clavicle Injuries
- Bone health and treatments
- Elbow and Forearm Trauma Treatment
- Bone Metabolism and Diseases
University Medical Center Utrecht
2016-2025
Heidelberg University
2021-2024
University Hospital Heidelberg
2021-2024
Wilhelmina Children's Hospital
2010-2023
Instituto Nacional de Cardiología
2023
Royal Manchester Children's Hospital
2022
Southwest Baptist University
2020
Shriners Hospitals for Children - Canada
2020
Erasmus University Rotterdam
2020
Erasmus MC
2020
Children with generalized hypermobility of the joints and musculoskeletal complaints frequently visit pediatric clinics, but many show no currently known collagen or other possibly related diseases. Whether symptoms are confined to system is unknown. We assessed whether such children have detectable differences in laxity connective tissue present organ systems than joints. also joint more profound systemic changes various as compared without complaints.Anthropometrics, range motion, muscle...
This study evaluated the accuracy of synthetic computed tomography (sCT), as compared to CT, for 3D assessment hip morphology. Thirty male patients with asymptomatic hips, referred magnetic resonance (MR) imaging and were included in this retrospective study. sCT images generated from three-dimensional radiofrequency-spoiled T1-weighted multi-echo gradient-echo MR using a commercially available deep learning-enabled software CT through mean error surface distance computation by means eight...
Severe osteogenesis imperfecta (OI) is a debilitating disease with no cure or sufficiently effective treatment. Mesenchymal stem cells (MSCs) have good safety profile, show promising effects and can form bone. The Boost Brittle Bones Before Birth (BOOSTB4) trial evaluates administration of allogeneic expanded human first trimester fetal liver MSCs (BOOST cells) for OI type 3 severe 4.
- A delegation of 6 pediatric orthopedic surgeons from the Dutch Orthopedic Association (NOV) and 2 members board Parents' for children with clubfoot created guideline "The diagnosis treatment primary idiopathic clubfeet" between April 2011 February 2014. The development was supported by a professional methodologist Knowledge Institute Medical Specialists. This evidence-based process new unique, in sense that initiated parents' association. is first official orthopedics Netherlands, to our...
Abstract Background Osteogenesis Imperfecta (OI) is a genetic disorder also known as ‘brittle bone disease’. The clinical manifestation of OI shows wide variation. Therefore, care for patients with requires an interdisciplinary approach. effectiveness particular interventions and treatment protocols teams not clear due to non-standardized variation patient outcomes thus making the comparison outcome measures available in literature difficult. It only by agreeing on common, standard set...
Although >80% of the mineral in mammalian bone is present collagen fibrils, limited information available about factors that determine a proper deposition mineral. This study investigates whether specific matrix required for fibril mineralization. Calcifying callus from dog tibias was obtained at various times (3-21 weeks) after fracturing. At 3 weeks, hydroxylysine (Hyl) levels were almost twice as high control bone, gradually reaching normal 21 weeks. The decrease Hyl can only be result...
We retrospectively studied the outcome of Pavlik harness treatment in late-diagnosed hip dislocation infants between 6 and 24 months age (Graf type 3 4 or dislocated hips on radiographs) treated our hospital 1984 2004. The was progressively applied to improve both flexion abduction hip. In case persistent adduction contracture, an splint added temporarily abduction.We included patients (26 hips) who presented with a primarily by mean at diagnosis 9 (range 23 mo). average follow-up years (2...
Abstract Background The effect of bracing over natural history stable dysplastic hips is not well known. This multicenter randomized trial aimed at objectifying the abduction treatment versus active surveillance in infants 3 to 4 months age. Methods Patients were either Pavlik harness or group. Ultrasound was repeated 6 and 12 weeks post randomization. primary outcome degree dysplasia using Graf α-angle measurement acetabular index (AI) on plain pelvis X-rays used identify persistent after 9...
Fractures in patients with osteogenesis imperfecta (OI) are caused by a decreased strength of bone due to quality and quantity matrix architecture. Mutations the collagen type 1 encoding genes cause altered formation I, one principal building blocks tissue. Due complexity disease high variation clinical problems between patients, treatment for these should be individually tailored. In general, short immobilization periods flexible casting material, use intramedullary implants, simultaneous...
Background: Preoperative planning of lower-limb realignment surgical procedures necessitates the quantification alignment parameters by using landmarks placed on medical scans. Conventionally, measurements are performed 2-dimensional (2D) standing radiographs. To enable fast and accurate 3-dimensional (3D) orthopaedic surgery, automatic calculation from 3D bone models is required. The goal this study was to develop, validate, apply a method that automatically quantifies defining computed...
In this prospective study of 18 hips we compared the efficacy ultrasound with CT in determining position femoral head a spica cast after closed or open reduction children developmental dysplasia hip. Ultrasound was performed through perineal opening cast. With transinguinal approach, superior ramus pubis, acetabulum, and neck can be depicted one plane. The images were blinded reviewed by two authors. inconclusive first reductions since too small to see all landmarks following 16 well defined...
SAKKERS, R. J. B. M.D.†; VAN DER HEUL, O. M.D., PH.D.†; KROON, H. M. TAMINIAU, A. HOGENDOORN, P. C. W. PH.D.†, LEIDEN, THE NETHERLANDS Author Information
In this double-blind randomised placebo-controlled trial it was investigated during a two-year follow-up whether oral bisphosphonates (Olpadronate 10 mg/m2/day) influence quality of life in children with osteogenesis imperfecta (OI). Thirty-four OI (classified according to Sillence criteria), aged 3 18 years age, restricted level ambulation were included. Randomisation performed using list computer generated random numbers allocate patients receive Olpadronate or placebo. Quality measured...
Purpose To collect and describe data on the natural history of abnormal ultrasound (US) findings in hips infants under six months age to serve as a reference design screening programmes treatment algorithms care for children with hip dysplasia. Methods A search PubMed terms “DDH” “ultrasound” was done find US that were not treated. In cases multiple periods follow-up, classification every period evaluated separately (individual follow-up periods). Results Data 13 561 16 991 collected...
Aims Open reduction is required following failed conservative treatment of developmental dysplasia the hip (DDH). The Ludloff medial approach commonly used, but poor results have been reported, with rates development avascular necrosis (AVN) varying between 8% and 54%. This retrospective cohort study evaluates long-term radiographic clinical outcome dislocated hips treated using this approach. Patients Methods Children a hip, younger than one year age at time surgery, who were eligible for...
Background: Dysostosis multiplex contributes substantially to morbidity in patients with Hurler syndrome (mucopolysaccharidosis type I phenotype [MPS I-H]), even after successful hematopoietic stem cell transplantation (HSCT). One of the hallmarks dysostosis MPS I-H is hip dysplasia, which often requires surgical intervention. We sought describe detail course dysplasia this group patients, as assessed by radiographic analysis, and identify potential outcome predictors. Methods: Longitudinal...