A5065914652- Radiation Therapy and Dosimetry
- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Nuclear Physics and Applications
- Radiation Detection and Scintillator Technologies
- Radiomics and Machine Learning in Medical Imaging
- Advanced X-ray and CT Imaging
- Gamma-ray bursts and supernovae
- Particle Detector Development and Performance
- Radiation Effects in Electronics
- Advanced MRI Techniques and Applications
- Laser-Plasma Interactions and Diagnostics
- Radiation Effects and Dosimetry
- Atomic and Subatomic Physics Research
- CCD and CMOS Imaging Sensors
- Laser-induced spectroscopy and plasma
- Atomic and Molecular Physics
- Photocathodes and Microchannel Plates
- Astro and Planetary Science
- Boron Compounds in Chemistry
- Astronomy and Astrophysical Research
- demographic modeling and climate adaptation
- Optical Imaging and Spectroscopy Techniques
- Cellular Automata and Applications
- Particle accelerators and beam dynamics
Ludwig-Maximilians-Universität München
2015-2024
MSB Medical School Berlin
2023
Metropolitan University
2021
Maastro Clinic
2018
Maastricht University
2018
University Hospital Heidelberg
2013-2017
Heidelberg University
2013-2017
Politecnico di Milano
2011-2016
Jagiellonian University
2016
Institute of Physics
2016
Artifacts affect 4D CT images due to breathing irregularities or incorrect phase identification. The purpose of this study is the reduction artifacts in sorted images. assumption that use multiple respiratory related signals may reduce uncertainties and increase robustness identification.Multiple were provided by infrared 3D localization a configuration markers placed on thoracoabdominal surface. Multidimensional K-means clustering was used for retrospective image sorting, which based marker...
Ion computed tomography (iCT) represents a potential replacement for x-ray CT (xCT) in ion therapy treatment planning to reduce range uncertainties, inherent the semi-empirical conversion of xCT information into relative stopping power (RSP). In this work, we aim quantify increase dosimetric accuracy associated with using proton-, helium- and carbon-CT compared conventional clinical scenarios proton therapy. Three cases imaged active beam-delivery an ideal single-particle-tracking detector...
Several techniques are under development for image-guidance in particle therapy. Positron (β+) emission tomography (PET) is use since many years, because accelerated ions generate positron-emitting isotopes by nuclear fragmentation the human body. In heavy ion therapy, a major part of PET signals produced β+-emitters generated via projectile fragmentation. A much higher intensity signal can be obtained using β+-radioactive beams directly treatment. This idea has always been hampered low...
Particle therapy (PT) has shown positive therapeutic results in local control of locally advanced pancreatic lesions. PT effectiveness is highly influenced by target localization accuracy both space, since the pancreas located proximity to radiosensitive vital organs, and time as it subject substantial breathing-related motion. The purpose this preliminary study was quantify range motion under typical treatment conditions. Three common immobilization devices (vacuum cushion, thermoplastic...
Ion beam therapy offers the possibility of a highly conformal tumor-dose distribution; however, this technique is extremely sensitive to inaccuracies in treatment procedures. Ambiguities conversion Hounsfield units planning x-ray CT relative stopping power (RSP) can cause uncertainties estimated ion range up several millimeters. (iCT) represents favorable solution allowing directly assess RSP. In simulation study we investigate performance integration-mode configuration for carbon iCT,...
Intensity modulated radiation therapy (IMRT) and volumetric arc (VMAT) are relatively complex treatment delivery techniques require quality assurance (QA) procedures. Pre-treatment dosimetric verification represents a fundamental QA procedure in daily clinical routine therapy. The purpose of this study is to develop an EPID-based approach reconstruct 3D dose distribution as imparted virtual cylindrical water phantom be used for plan-specific pre-treatment IMRT VMAT plans. For each depth, the...
The new developments of the FLUKA Positron-Emission-Tomography (PET) tools are detailed. is a fully integrated Monte Carlo (MC) particle transport code, used for an extended range applications, including Medical Physics. Recently, it provided medical community with dedicated simulation clinical PET package. well-established imaging technique in nuclear medicine, and promising method vivo treatment verification hadrontherapy. application clinically established scanners to irradiation...
The dosimetric advantages of ion therapy come at the cost an increased sensitivity to range inaccuracies in treatment planning and delivery stages. This prompts development imaging techniques capable accurate assessment relative stopping power (RSP). We investigate carbon-ion based on a prototype integration-mode detector working as telescope. Experiments were conducted Heidelberg Ion-Beam Therapy Center with active pencil beam scanning. aim this article is experimentally operate system...
A novel irradiation platform for preclinical proton therapy studies foresees imaging accurate setup and treatment planning. Imaging at modern synchrocyclotron-based centers with high instantaneous particle flux is possible an integration mode setup. The aim of this work to determine object’s water-equivalent thickness (WET) a commercially available large-area CMOS sensor. Image contrast achieved by recording the energy deposition in detector pixels several incoming beam energies (here,...
A common approach for spectrum determination of polyenergetic proton bunches from laser-ion acceleration experiments is based on the time-of-flight (TOF) method. However, spectra obtained using this method are typically given in relative units or estimated some prior assumptions energy distribution accelerated ions. In work, we present a new TOF that allows an absolute reconstruction current signal acquired with sub-nanosecond fast and 10 µm thin silicon detector. The solving linear...
The purpose of this work is to investigate the potentiality using a limited number in-room proton radiographies compensate anatomical changes in adaptive therapy. treatment planning CT adapted delivery scenario relying on 2D-3D deformable image registration (DIR). radiographies, expressed water equivalent thickness (WET) are simulated for both list-mode and integration-mode detector configurations pencil beam scanning. Geometrical analytical simulations an anthropomorphic phantom presence...
Abstract The aim of this work is to investigate in-room proton radiographies compensate realistic rigid and non-rigid transformations in clinical-like scenarios based on 2D–3D deformable image registration (DIR) framework towards future clinical implementation adaptive radiation therapy (ART). Monte Carlo simulations (pRads) x-ray CT a head neck, brain tumor patients are simulated for two different detector configurations (i.e. integration-mode list-mode detectors) including high low...
Objective.We designed a geometrical solution for small animal in-beam positron emission tomography (PET) scanner to be used in the project SIRMIO (Small proton irradiator research molecular image-guided radiation-oncology). The system is based on 56 scintillator blocks of pixelated LYSO crystals. crystals are arranged providing pyramidal-step shape optimize coverage spherical configuration.Approach.Different arrangements have been simulated and compared terms spatial resolution sensitivity....
The purpose of the study is to evaluate performance a novel strategy, referred as "virtual 4D PET", aiming at optimization hybrid CT-PET scan for radiotherapy treatment planning. virtual PET strategy applies CT motion modeling avoid time-resolved image acquisition. This leads reduction radioactive tracer administered patient and total acquisition time comparable free-breathing studies. proposed method exploits model derived from CT, which applied recover respiratory blur. warped according...
A clinical trial named PROMETHEUS is currently ongoing for inoperable hepatocellular carcinoma (HCC) at the Heidelberg Ion Beam Therapy Center (HIT, Germany). In this framework, 4D PET-CT datasets are acquired shortly after therapeutic treatment to compare irradiation induced PET image with a Monte Carlo prediction resulting from simulation of delivery. The extremely low count statistics measured represents major limitation technique, especially in presence target motion. purpose study...
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