A5003370359- Radiation Detection and Scintillator Technologies
- Nuclear Physics and Applications
- Radiation Therapy and Dosimetry
- Atomic and Subatomic Physics Research
- Medical Imaging Techniques and Applications
- Advanced Radiotherapy Techniques
- Particle Detector Development and Performance
- Nuclear physics research studies
- Nuclear reactor physics and engineering
- Advanced X-ray and CT Imaging
- Radioactive contamination and transfer
- Atomic and Molecular Physics
- High-Energy Particle Collisions Research
- Nuclear Materials and Properties
- Radiation Effects in Electronics
- Dark Matter and Cosmic Phenomena
- Silicon and Solar Cell Technologies
- Astronomical and nuclear sciences
- Calibration and Measurement Techniques
- Radioactivity and Radon Measurements
- Particle accelerators and beam dynamics
- Advanced MRI Techniques and Applications
- Luminescence Properties of Advanced Materials
- Ion-surface interactions and analysis
- Neutrino Physics Research
Target (Germany)
2005-2024
Target (United States)
2024
Helmholtz-Zentrum Dresden-Rossendorf
1999-2020
University Hospital Carl Gustav Carus
2014-2020
OncoRay
2013-2020
TU Dresden
1986-2020
Centro Brasileiro de Pesquisas Físicas
2016
European Synchrotron Radiation Facility
2016
Université Joseph Fourier
2016
Inserm
2016
Proton and ion beams open up new vistas for the curative treatment of tumors, but adequate technologies monitoring compliance dose delivery with plans in real time are still missing. Range assessment, meaning therapy-particle ranges tissue during (treatment), is a continuous challenge considered key tapping full potential particle therapies. In this context paper introduces an unconventional concept range assessment by prompt-gamma timing (PGT), which based on elementary physical effect not...
Ion beam therapy promises enhanced tumour coverage compared to conventional radiotherapy, but particle range uncertainties significantly blunt the achievable precision. Experimental tools for verification in real-time are not yet available clinical routine. The prompt gamma ray timing method has been recently proposed as an alternative collimated imaging systems. detection times of rays encode essential information about depth-dose profile thanks measurable transit time ions through matter....
In proton therapy, patients benefit from the precise deposition of dose in tumor volume due to interaction charged particles with matter. Currently, determination beam range patient's body during treatment is not a clinical standard. This lack causes broad safety margins around tumor, which limits potential therapy. To overcome this obstacle, different methods are under investigation aiming at verification real time irradiation. One approach prompt gamma-ray timing (PGT) method, where...
The finite range of a proton beam in tissue opens new vistas for the delivery highly conformal dose distribution radiotherapy. However, actual particle range, and therefore accurate deposition, is sensitive to composition path. Range uncertainties, resulting from limited knowledge this or positioning errors, are accounted form safety margins. Thus, unverified constrains principle benefit therapy. Detecting prompt γ-rays, side product proton-tissue interaction, aims at an on-line non-invasive...
In the context of ion beam therapy, particle range verification is a major challenge for quality assurance treatment. One approach measurement prompt gamma rays resulting from tissue irradiation. A Compton camera based on several position sensitive ray detectors, together with an imaging algorithm, expected to reconstruct emission density map, which correlated dose distribution. At OncoRay and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), setup being developed consisting two scatter planes:...
Proton therapy is an advantageous treatment modality compared to conventional radiotherapy. In contrast photons, charged particles have a finite range and can thus spare organs at risk. Additionally, the increased ionization density in so-called Bragg peak close particle be utilized for maximum dose deposition tumour volume. Unfortunately, accuracy of affected by uncertainties, which covered additional safety margins around A real-time verification therefore highly desired would key exploit...
Abstract Particle therapy (PT) used for cancer treatment can spare healthy tissue and reduce toxicity. However, full exploitation of the dosimetric advantages PT is not yet possible due to range uncertainties, warranting development range-monitoring techniques. This study proposes a novel technique introducing unexplored concept simultaneous detection imaging fast neutrons prompt-gamma rays produced in beam-tissue interactions. A quasi-monolithic organic detector array proposed, its...
The properties of CdWO/sub 4/ (CWO) crystals in gamma spectrometry were studied. Several small samples 10/spl times/10/spl times/3 mm size, typically used CT X-ray detectors, tested and then compared to the performance a larger crystal 20 diameter height. light output, energy resolution, nonproportionality CWO response versus gamma-ray energy, measured with those BGO discuss further origin intrinsic resolution pure undoped scintillating crystals. A high output 6500/spl plusmn/200 phe/MeV...
To ensure the optimal outcome of proton therapy, in vivo range verification is highly desired. Prompt γ-ray imaging (PGI) a possible approach for monitoring. For PGI, dedicated detection systems, e.g. Compton cameras, are currently under investigation. The presented paper deals with substantial requirements regarding hardware and software that camera used clinical routine has to meet. By means GEANT4 simulations, we investigate load on detectors percentage background expected realistic...
The dose deposition profile of protons is interesting for tumour treatment due to the increased ionization density at end their track. However, inaccurate knowledge proton stopping point limits precision therapy. Prompt gamma rays, a by-product irradiation, are candidates an indirect measurement particle range. Compton cameras have been proposed prompt ray imaging, but struggle with high trigger rates and low coincident efficiency. feasibility in clinical environment has yet be proved. At...
Range verification of particle beams in real time is considered a key for tapping the full potential radio-oncological therapies. The novel technique prompt gamma-ray timing (PGT), recently proposed and explored first proof-of-principle experiments, promises range assessment at reasonable expense but challenges detectors, electronics, data acquisition. Energy-selected distributions have to be measured very high throughput rates obtain statistics necessary with single pencil beam spots....
Prompt γ-ray imaging with a knife-edge shaped slit camera provides the possibility of verifying proton beam range in tumor therapy. Dedicated experiments regarding characterization system have been performed previously. Now, we aim at implementing prototype into clinical application monitoring patient treatments. Focused on this goal translation operation, systematically addressed remaining challenges and questions. We developed robust energy calibration routine corresponding quality...
The annihilation of energetic (1.2 GeV) antiprotons is exploited to deposit maximum thermal excitation (up 1000 MeV) in massive nuclei (Cu, Ho, Au, and U) while minimizing the contribution from collective such as rotation, shape distortion, compression. Excitation energy distributions $d\ensuremath{\sigma}/{\mathrm{dE}}^{*}$ are deduced eventwise observation whole nuclear evaporation chain with two $4\ensuremath{\pi}$ detectors for neutrons charged particles. produced this way found decay...
A BC523A liquid scintillator loaded with boron-10 was tested as a detector for both fast and thermal neutrons. pulse shape discrimination (PSD) method based on zero-crossing principle applied to distinguish between neutron gamma radiation. High quantum efficiency Photonis XP5500B photomultiplier used enhance light detection from the scintillator. This allowed good registration of energy spectrum capture events boron-10, corresponding about 60 keV gamma-rays. The PSD proved be useful n/gamma...
The performance of several BrilLanCe LaBr <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> crystals that range in size from Oslash 6 times mm <sup xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> up to 38 coupled XP5212 and R6231MOD photomultipliers were studied, the case small crystals, also large area avalanche photodiodes (LAAPD) Advanced Photonix, Inc. First, Photonis Hamamatsu with compared select best one, not affecting energy...
Boron-10 loaded liquid scintillators were studied in order to improve n/¿ separation. Pulse shape discrimination (PSD) was implemented by means of a zero-crossing (ZC) method distinguish between ¿-rays and fast/slow neutrons. Significant progress done for BC523A2 EJ339A2 with reduced amount <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">10</sup> B (2% 2.5%, respectively), as compared the results obtained earlier BC523A 4.4% B. The improvement...
Light yield nonproportionality and the intrinsic resolution of some low atomic number scintillators were studied by means Wide Angle Compton Coincidence (WACC) technique. The plastic liquid scintillator response to electrons was measured in energy range 10 keV up 4 MeV, whereas a CaF2:Eu sample scanned from 3 1 MeV. light has characteristics typical for inorganic multivalent halides group, tested organic show steeply increasing without saturation point. This is contrast behavior all known...