A5044032807- Radiation Therapy and Dosimetry
- Advanced Radiotherapy Techniques
- Radiation Detection and Scintillator Technologies
- Advanced MRI Techniques and Applications
- Nuclear Physics and Applications
- Atomic and Subatomic Physics Research
- Radiation Effects in Electronics
- Advanced NMR Techniques and Applications
- Healthcare Technology and Patient Monitoring
- Medical Imaging Techniques and Applications
- Particle Detector Development and Performance
- Surgical Simulation and Training
- Solar and Space Plasma Dynamics
- Electromagnetic Fields and Biological Effects
- Radiation Effects and Dosimetry
- Radiation Dose and Imaging
TU Dresden
2018-2024
Helmholtz-Zentrum Dresden-Rossendorf
2017-2024
OncoRay
2017-2024
University Hospital Carl Gustav Carus
2018-2024
Zittau/Görlitz University of Applied Sciences
2023-2024
On-line image guidance using magnetic resonance (MR) imaging is expected to improve the targeting accuracy of proton therapy. However, date no combined system exists. In this study, for first time a low-field open MR scanner was integrated with static research beam line test feasibility simultaneous irradiation and imaging. The field-of-view aligned by taking into account Lorentz force induced deflection. Various sequences extremities were performed on healthy volunteer patient soft-tissue...
Abstract Particle therapy (PT) used for cancer treatment can spare healthy tissue and reduce toxicity. However, full exploitation of the dosimetric advantages PT is not yet possible due to range uncertainties, warranting development range-monitoring techniques. This study proposes a novel technique introducing unexplored concept simultaneous detection imaging fast neutrons prompt-gamma rays produced in beam-tissue interactions. A quasi-monolithic organic detector array proposed, its...
The integration of magnetic resonance imaging (MRI) and proton therapy for on-line image-guidance is expected to reduce dose delivery uncertainties during treatment. Yet, the beam experiences a Lorentz force induced deflection inside field MRI scanner, several methods have been proposed quantify this effect. We analyze their structural differences compare results both analytical Monte Carlo models. find that existing models are limited in accuracy applicability due critical approximations,...
Given the sensitivity of proton therapy to anatomical variations, this cancer treatment modality is expected benefit greatly from integration with magnetic resonance (MR) imaging. One obstacles hindering such an are strong field induced dose distortions. These have been predicted in simulation studies, but no experimental validation has performed so far. Here we show first measurement planar distributions deposited by therapeutic pencil beams traversing a one-Tesla transversal while...
The main advantage proton beams offer over photon in radiation therapy of cancer patients is the dose maximum at their finite range, yielding a reduction deposited healthy tissues surrounding tumor. Since no direct method exists to measure beam's range during delivery, safety margins around tumor are applied, compromising conformality and reducing targeting accuracy. Here, we demonstrate that online MRI can visualize beam reveal its irradiation liquid-filled phantoms. A clear dependence on...
Abstract For accurate and simultaneous imaging of fast neutrons (FNs) prompt gamma rays (PGs) produced during proton therapy, the selection a highly performant detector material is crucial. In this work, promising candidate known as organic glass scintillator (OGS) characterized for task. To end, precisely-timed source Bremsstrahlung radiation by n ELBE facility was used to study light output neutron/gamma ray pulse shape discrimination (PSD) properties 1 × 20 cm 3 OGS bar with double-sided...
Proton therapy (PT) is expected to benefit from integration with magnetic resonance (MR) imaging. However, the field distorts dose distribution and enhances at tissue-air interfaces by electron return effect (ERE). The objectives were (a) provide experimental evidence for ERE in proton beams (b) systematically characterise dependence of enhancement ratio (DER) on strength, orientation, energy voxel size computer simulations. EBT3 films irradiated 200 MeV protons without a 0.92 T transverse...
We present an improved method for in-vivo proton range verification by prompt gamma-ray timing based on multivariate statistical modelling. To this end, distributions acquired during pencil beam irradiation of acrylic glass phantom with air cavities different thicknesses were analysed. Relevant distribution features chosen using forward variable selection and the Least Absolute Shrinkage Selection Operator (LASSO) from a feature assortment recommendations Image Biomarker Standardisation...
Robust and fast in vivo treatment verification is expected to increase the clinical efficacy of proton therapy. The combined detection prompt gamma rays neutrons has recently been proposed for this purpose shown monitoring accuracy. However, potential technique not fully exploited yet since range reconstruction relies only on a simple landmark particle production distributions. Here, we apply machine learning based feature selection multivariate modelling improve accuracy system an exemplary...
Purpose To report on experimental results of a high spatial resolution silicon‐based detector exposed to therapeutic quality proton beams in 0.95 T transverse magnetic field. These are important for the development accurate and novel dosimetry methods future potential real‐time MRI‐guided therapy systems. Methods A permanent magnet device was utilized generate field over 4 × 20 15 cm 3 volume. Within this volume, high‐resolution silicon diode array positioned inside PMMA phantom 12 . This...
ConclusionFor the first time, ERE for proton beams in a transverse magnetic field was demonstrated experimentally.The significant dose enhancement is predictable and limited to within 1 mm from air interface under clinically relevant conditions.Although smaller than MRXT, may affect clinical treatment of e.g.lung tumors dosimetry with airfilled ionization chambers.
Image guidance using <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">in-beam</i> real-time magnetic resonance (MR) imaging is expected to improve the targeting accuracy of proton therapy for moving tumors, by reducing treatment margins, detecting interfractional and intrafractional anatomical changes enabling beam gating. The aim this study quantitatively characterize static field image quality a 0.22T open MR scanner that has been integrated...
. Prompt gamma-ray timing is an emerging technology in the field of particle therapy treatment verification. This system measures arrival times gamma rays produced patient body and uses cyclotron radio frequency signal as time reference for beam micro-bunches. Its translation into clinical practice currently hindered by observed instabilities phase relation between measured prompt rays. To counteract this, two proton bunch monitors are presented, integrated workflow evaluated.
Particle therapy has proven highly sensitive range uncertainties, making online verification essential. Here we present a status update on work by the NOVO collaboration investigating through simultaneous imaging of prompt gamma-rays and fast neutrons. The proposed system is designed to offer high detection sensitivity shifts with smaller footprint cost than current state-of-the art systems, where proton can be calculated elastically scattered neutrons emitted from patient tissues during...
Range verification is essential to develop the full potential of proton therapy. The prompt gamma-ray timing method [1]-[2] a promising candidate for its clinical realization, since it light-weight system with small footprint, which can be easily integrated into existing treatment facilities.To verify applicability this system, range deviations were introduced on realistic head phantom using plastic plates up 7 mm thickness. produced gamma radiation was detected simultaneously by eight...
ConclusionThe proposed method of analysis isolated errors gives the magnitude errors.In general, most important are leaf gap width errors.Exception and further is required for VMAT patients with low DR.ArcCheck positioning should not affect gamma results while being in specification tolerance.
ConclusionThis study demonstrates that in both cohorts, PET textural features derived using a fixed bin count are largely independent from SUVmax, SUVmean, and MATV.Their independency decreases when width.Clear guidelines for feature analysis, including SUV binning, selection necessary to avoid collinearity.The next step is assess the prognostic value of its variability multiple patient cohorts pre-treatment response imaging.
Abstract Particle therapy (PT) used for cancer treatment can spare healthy tissue and reduce toxicity. However, full exploitation of the dosimetric advantages PT is not yet possible due to range uncertainties, warranting development range-monitoring techniques. This study proposes a novel technique introducing unexplored concept simultaneous detection imaging fast neutrons prompt-gamma rays produced in beam-tissue interactions. A quasi-monolithic organic detector array proposed, its...