A5009356670- Radiation Detection and Scintillator Technologies
- Radiation Therapy and Dosimetry
- Advanced Radiotherapy Techniques
- Nuclear Physics and Applications
- Medical Imaging Techniques and Applications
- Advanced X-ray and CT Imaging
- Prostate Cancer Diagnosis and Treatment
- Radiation Effects in Electronics
- Digital Radiography and Breast Imaging
- Laser Design and Applications
- Solid State Laser Technologies
- Particle Detector Development and Performance
- Advanced Fiber Laser Technologies
- Prostate Cancer Treatment and Research
- Laser-Matter Interactions and Applications
- Calibration and Measurement Techniques
- Nuclear reactor physics and engineering
- Particle accelerators and beam dynamics
- Soft Robotics and Applications
- Gyrotron and Vacuum Electronics Research
- Radiopharmaceutical Chemistry and Applications
- Radioactivity and Radon Measurements
- Dark Matter and Cosmic Phenomena
- Space Satellite Systems and Control
Instituto de Física Corpuscular
2021-2025
Universitat de València
2015-2024
Massachusetts General Hospital
2017-2024
Harvard University
2017-2024
Helmholtz-Zentrum Dresden-Rossendorf
2014-2018
Target (Germany)
2016-2017
University Hospital Carl Gustav Carus
2014-2016
OncoRay
2013-2016
Technische Universität Dresden
2013-2016
Colorado State University
1988
We present a full-scale clinical prototype system for in vivo range verification of proton pencil-beams using the prompt gamma-ray spectroscopy method. The detection consists eight LaBr3 scintillators and tungsten collimator, mounted on rotating frame. Custom electronics calibration algorithms have been developed measurement energy- time-resolved spectra during irradiation at dose rate. Using experimentally determined nuclear reaction cross sections GPU-accelerated Monte Carlo simulation,...
Proton and ion beams open up new vistas for the curative treatment of tumors, but adequate technologies monitoring compliance dose delivery with plans in real time are still missing. Range assessment, meaning therapy-particle ranges tissue during (treatment), is a continuous challenge considered key tapping full potential particle therapies. In this context paper introduces an unconventional concept range assessment by prompt-gamma timing (PGT), which based on elementary physical effect not...
Ion beam therapy promises enhanced tumour coverage compared to conventional radiotherapy, but particle range uncertainties significantly blunt the achievable precision. Experimental tools for verification in real-time are not yet available clinical routine. The prompt gamma ray timing method has been recently proposed as an alternative collimated imaging systems. detection times of rays encode essential information about depth-dose profile thanks measurable transit time ions through matter....
In proton therapy, patients benefit from the precise deposition of dose in tumor volume due to interaction charged particles with matter. Currently, determination beam range patient's body during treatment is not a clinical standard. This lack causes broad safety margins around tumor, which limits potential therapy. To overcome this obstacle, different methods are under investigation aiming at verification real time irradiation. One approach prompt gamma-ray timing (PGT) method, where...
The finite range of a proton beam in tissue opens new vistas for the delivery highly conformal dose distribution radiotherapy. However, actual particle range, and therefore accurate deposition, is sensitive to composition path. Range uncertainties, resulting from limited knowledge this or positioning errors, are accounted form safety margins. Thus, unverified constrains principle benefit therapy. Detecting prompt γ-rays, side product proton-tissue interaction, aims at an on-line non-invasive...
In the context of ion beam therapy, particle range verification is a major challenge for quality assurance treatment. One approach measurement prompt gamma rays resulting from tissue irradiation. A Compton camera based on several position sensitive ray detectors, together with an imaging algorithm, expected to reconstruct emission density map, which correlated dose distribution. At OncoRay and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), setup being developed consisting two scatter planes:...
Proton therapy is an advantageous treatment modality compared to conventional radiotherapy. In contrast photons, charged particles have a finite range and can thus spare organs at risk. Additionally, the increased ionization density in so-called Bragg peak close particle be utilized for maximum dose deposition tumour volume. Unfortunately, accuracy of affected by uncertainties, which covered additional safety margins around A real-time verification therefore highly desired would key exploit...
The IRIS group of IFIC-Valencia has developed a Compton camera prototype. system detectors are made Lanthanum (III) bromide scintillator crystals coupled to silicon photomultipliers. Two models photomultipliers arrays with different micro pixel pitch (25 and 50 μm) have been chosen as possible candidates improve the response new system. Characterization studies 22Na point-like source indicated that 25 μm photodetector provided better performance in terms energy resolution (5.2% FWHM at 511...
To ensure the optimal outcome of proton therapy, in vivo range verification is highly desired. Prompt γ-ray imaging (PGI) a possible approach for monitoring. For PGI, dedicated detection systems, e.g. Compton cameras, are currently under investigation. The presented paper deals with substantial requirements regarding hardware and software that camera used clinical routine has to meet. By means GEANT4 simulations, we investigate load on detectors percentage background expected realistic...
The dose deposition profile of protons is interesting for tumour treatment due to the increased ionization density at end their track. However, inaccurate knowledge proton stopping point limits precision therapy. Prompt gamma rays, a by-product irradiation, are candidates an indirect measurement particle range. Compton cameras have been proposed prompt ray imaging, but struggle with high trigger rates and low coincident efficiency. feasibility in clinical environment has yet be proved. At...
Range verification of particle beams in real time is considered a key for tapping the full potential radio-oncological therapies. The novel technique prompt gamma-ray timing (PGT), recently proposed and explored first proof-of-principle experiments, promises range assessment at reasonable expense but challenges detectors, electronics, data acquisition. Energy-selected distributions have to be measured very high throughput rates obtain statistics necessary with single pencil beam spots....
Irradiation with protons and light ions offers new possibilities for tumor therapy but has a strong need novel imaging modalities treatment verification. The development of detector systems, which can provide an in vivo range assessment or dosimetry, requires accurate knowledge the secondary radiation field reliable Monte Carlo simulations. This paper presents multiple measurements to characterize prompt γ-ray emissions during proton irradiation benchmarks latest Geant4 code against...
Compton camera prototype for a position-sensitive detection of prompt <i>γ<i/> rays from proton-induced nuclear reactions is being developed in Garching. The detector system allows to track the Comptonscattered electrons. consists monolithic LaBr<sub>3<sub/>:Ce scintillation absorber crystal, read out by multi-anode PMT, preceded stacked array 6 double-sided silicon strip detectors acting as scatterers. crystal has been characterized with radioactive sources. Online commissioning...
A major weakness of ion beam therapy is the lack tools for verifying particle range in clinical routine. The application Compton camera concept imaging prompt gamma rays, a by-product irradiation correlated to dose distribution, promising approach assessment and even three-dimensional vivo dosimetry.
The use of Compton cameras for medical imaging and its interest as a hadron therapy treatment monitoring has increased in the last decade with development silicon photomultipliers. MACACOp is camera prototype designed assembled at IRIS group IFIC-Valencia. This based on monolithic Lanthanum (III) Bromide crystals photomultipliers, employs novel TOFPET2 ASIC readout electronics. system emerged an alternative to MACACO II prototype, aim improving limited time resolution. To test performance...
Particle therapy in oncology is advantageous compared to classical radiotherapy due its well-defined penetration depth. In the so-called Bragg peak, highest dose deposited; tissue behind cancerous area not exposed. Different factors influence range of particle and thus target area, e.g. organ motion, mispositioning patient or anatomical changes. order avoid over-exposure healthy under-dosage regions, depth has be monitored, preferably already during ongoing session. The verification ion can...
In cancer patients undergoing proton therapy, a very intense secondary radiation is produced during the treatment, which lasts around one minute. About billion prompt gamma-rays are emitted per second, and their detection with fast scintillation detectors useful for monitoring correct beam delivery. To cope expected count rate pile-up, as well scarce statistics due to short treatment duration, we developed an eidetic data acquisition system capable of continuously digitizing detector signal...
Abstract Objective . To compare in reproducible and equalized conditions the performance of two independent proton range verification systems based on prompt gamma-ray detectors from different therapy centers. Approach An anthropomorphic head phantom with calibrated stopping power, serving as ground truth, was irradiated comparable treatment plans, spot positions energies both facilities. Clinical beam current, tumor contour dose were used. The absolute measurement compared to expected value...
Proton therapy has a substantial physical advantage over conventional cancer radiation treatment with X-rays. reduces the dose to healthy tissues and therefore toxicity side effects patients. However, current high capital cost required space make proton very limited resource. In therapy, patient is fixed on table gantry used bend beam for treatment. We propose change model by precisely moving relative rather than patient. This requires robot move strong immobilization device ensure that...
We present an open-source platform to aid medical dosimetrists in preventing collisions between gantry head and patient or couch during photon particle beam therapy treatment planning. This generic framework uses the native scripting interface of particular planning software import STL files machine elements. These are visualized 3D together with contoured scanned surface. A graphical dialog sliders allows interactive rotation couch, real-time feedback. To prevent a future replanning,...
The paper "SPICE Model of Photomultiplier Tube Under Different Bias Conditions" is commented.We revisit the mathematical formulation to compensate for some ambiguities in original manuscript, and point out inconsistencies results reproducibility simulations, as well optimized parameters originally obtained with PSPICE simulation engine.All simulations are recalculated NGSPICE software using corrected compared against figures.The our independently verified PSPICE, by numerically solving...
The electron amplification and transport within a photomultiplier tube (PMT) has been investigated by developing an in-house Monte Carlo simulation code. secondary emission in the dynodes is implemented via effective model Modified Vaughan's model, whereas computed with Boris leapfrog algorithm. PMT gain, rise time transit have studied as function of supply voltage external magnetostatic field. A good agreement experimental measurements using Hamamatsu R13408-100 was obtained. simulations...