A5073484647- Radiation Detection and Scintillator Technologies
- Medical Imaging Techniques and Applications
- Atomic and Subatomic Physics Research
- Radiation Therapy and Dosimetry
- Advanced MRI Techniques and Applications
- Nuclear Physics and Applications
- Advanced Optical Sensing Technologies
- Radiopharmaceutical Chemistry and Applications
- Neutrino Physics Research
- Advanced Radiotherapy Techniques
Delft University of Technology
2012-2018
Istituto Nazionale di Fisica Nucleare, Sezione di Napoli
2010
New applications for positron emission tomography (PET) and combined PET/magnetic resonance imaging (MRI) are currently emerging, example in the fields of neurological, breast, pediatric imaging. Such require improved image quality, reduced dose, shorter scanning times, more precise quantification. This can be achieved by means dedicated scanners based on ultrahigh-performance detectors, which should provide excellent spatial resolution, depth-of-interaction (DOI) estimation, outstanding...
Gamma-ray detectors based on thick monolithic scintillator crystals can achieve spatial resolutions <2 mm full-width-at-half-maximum (FWHM) and coincidence resolving times (CRTs) better than 200 ps FWHM. Moreover, they provide high sensitivity depth-of-interaction (DOI) information. While these are excellent characteristics for clinical time-of-flight (TOF) positron emission tomography (PET), the application of scintillators has so far been hampered by lengthy complex procedures needed...
Recently, a monolithic scintillator detector for time-of-flight (TOF)/depth-of-interaction (DOI) positron emission tomography (PET) was developed. It has spatial resolution of ~1.7 mm full-width-at-half-maximum (FWHM), coincidence resolving time (CRT) ~215 ps FWHM, and ~4.7 FWHM DOI resolution. Here, we demonstrate, the first time, imaging performance this in 70 cm diameter PET geometry. We built tomographic setup representative whole-body clinical scanner, comprising two coaxially rotating...
A digital silicon photomultiplier (dSiPM) consists of an array single photon avalanche diodes (SPADs) operating in Geiger-mode. Each SPAD is connected to a dedicated CMOS quenching and digitization circuit. One type dSiPM the Digital Photon Counter (DPC) manufactured by Philips Counting (PDPC). Due architecture device, DPC can be adapted optimized for different applications through set adjustable acquisition parameters. The influence these parameters must well understood correct use sensor....
Monolithic scintillator detectors can achieve excellent spatial resolution and coincidence resolving time. However, their practical use for positron emission tomography (PET) other applications in the medical imaging field is still limited due to drawbacks of different methods used estimate position interaction. Common statistical example require collection an extensive dataset reference events with a narrow pencil beam aimed at fine grid positions. Such procedures are time consuming not...
Positron emission tomography (PET) is the imaging modality most extensively tested for treatment monitoring in particle therapy. Optimal use of PET proton therapy requires situ acquisition relatively strong (15)O signal due to its short half-life (~2 min) and high oxygen content biological tissues, enabling shorter scans that are less sensitive washout. This paper presents first performance tests a scaled-down time-of-flight (TOF) system based on digital photon counters (DPCs) coupled...
The goal of this simulation study is the performance evaluation and comparison six potential designs for a time-of-flight PET scanner pediatric patients up to about 12 years age. It designed have high sensitivity provide high-contrast high-resolution images. simulated full ring scanner, consisting 32 × mm2 monolithic LYSO:Ce crystals coupled digital silicon photomultiplier arrays. considered differ in axial lengths (27.2 cm, 54.4 cm 102 cm) crystal thicknesses (22 mm 11 mm). simulations are...
Gamma-ray detectors based on bright monolithic scintillation crystals coupled to pixelated photodetectors are currently being considered for several applications in the medical imaging field. In a typical detector, both light intensity and time of arrival earliest photons can be recorded by each photosensor pixels every gamma interaction occurs. Generally, stamps used determine while intensities estimate 3D position point. this work we show that spatio-temporal distribution also carries...
We have recently built and characterized the performance of a monolithic scintillator detector based on 32 mm × 22 LYSO:Ce crystal read out by digital silicon photomultiplier (dSiPM) arrays coupled to front back surfaces in dual-sided readout (DSR) configuration. The spatial resolution appeared be markedly better than that consisting same with conventional back-sided (BSR). Here, we aim evaluate influence this difference response quality reconstructed images, so as quantify potential benefit...
Time of Flight (TOF) Positron Emission Tomography (PET) produces an improvement in signal-to-noise ratio (SNR) over conventional non-TOF reconstruction. This increases with the size patient and better coincidence time resolution system. As a first approximation TOF PET reconstruction, this gain SNR is independent scatter randoms components total signal. On other hand, recently model has been proposed which vs. growing function (number random coincidences divided by number trues plus...
PSMR 2015: 4th Conference on PET/MR and SPECT/MR, La Biodola, Isola d’Elba, Italy, 17-21 May 2015
Time of Flight (TOF) Positron Emission Tomography (PET) produces an improvement in signal-to-noise ratio (SNR) over conventional non-TOF reconstruction. This increases with the size patient and better coincidence time resolution system. As a first approximation TOF PET reconstruction, this gain SNR is independent scatter random components total signal. On other hand, recently model has been proposed which vs. growing function events fraction. would provide additional advantage reconstruction...