A5061986597- Medical Imaging Techniques and Applications
- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Neonatal and fetal brain pathology
- Advanced Neuroimaging Techniques and Applications
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Infant Development and Preterm Care
- Liver Disease Diagnosis and Treatment
- Cardiovascular Disease and Adiposity
- Muscle metabolism and nutrition
- Cardiovascular Function and Risk Factors
- Renal and Vascular Pathologies
- Cardiovascular and exercise physiology
- Bone and Joint Diseases
- Multiple Sclerosis Research Studies
- Bariatric Surgery and Outcomes
- Adipokines, Inflammation, and Metabolic Diseases
- Alzheimer's disease research and treatments
- Nutrition and Health in Aging
- Cerebral Palsy and Movement Disorders
- Neonatal Respiratory Health Research
- Cerebrovascular and Carotid Artery Diseases
Turku University Hospital
2015-2024
Turku PET Centre
2015-2024
University of Turku
2015-2024
Åbo Akademi University
2022-2024
Turku University of Applied Sciences
2018
The aim of this study was to investigate tissue-specific effects dapagliflozin on insulin sensitivity and liver body fat in patients with type 2 diabetes.This randomized, double-blind, parallel group, placebo-controlled recruited 32 diabetes. Enrolled were have HbA1c 6.5-10.5% (48-91 mmol/mol) ≥3 months stable treatment metformin, dipeptidyl peptidase 4 inhibitor, or their combination. Patients randomized 1:1 receive 10 mg placebo daily for 8 weeks. Before after the intervention, tissue...
Pancreatic fat accumulation may contribute to the development of beta cell dysfunction. Exercise training improves whole-body insulin sensitivity, but its effects on pancreatic content and dysfunction are unclear. The aim this parallel-group randomised controlled trial was evaluate exercise function in healthy prediabetic or type 2 diabetic participants test whether responses were similar regardless baseline glucose tolerance. Using newspaper announcements, a total 97 sedentary...
Sirtuins (SIRTs) and poly(ADP-ribose) polymerases (PARPs) are 2 important nicotinamide adenine dinucleotide (NAD)(+)-dependent enzyme families with opposing metabolic effects. Energy shortage increases NAD(+) biosynthesis SIRT activity but reduces PARP in animals. Effects of energy balance on these pathways humans unknown.We compared NAD(+)/SIRT pathway expressions activities sc adipose tissue (SAT) between lean obese subjects investigated their change the during a 12-month weight loss.SAT...
Prenatal stress is associated with child behavioral outcomes increasing susceptibility for psychiatric disorders in later life. Altered fetal brain development might partly mediate this association, as some studies suggest. With study, we investigated the relation between prenatal stress, child's structure and problems. The association self-reported maternal pregnancy-related anxiety (PRAQ-R2 questionnaire, second third trimester) gray matter volume was probed 27 4-year-old children (13...
Metabolic imaging studying brown adipose tissue (BAT) physiology has increased, in which computed tomography (CT) is commonly used as an anatomical reference for metabolic positron emission (PET) imaging. However, the capacity of CT to provide information been underexploited.To evaluate whether radiodensity BAT could noninvasively estimate underlying morphology, regarding amount stored triglycerides. Furthermore, alteration characteristics due cold stimulus, a marker active BAT, be detected...
Aims To test the hypothesis that high‐intensity interval training (HIIT) and moderate‐intensity continuous (MICT) improve brown adipose tissue (BAT) insulin sensitivity. Participants methods Healthy middle‐aged men (n = 18, age 47 years [95% confidence {CI} 49, 43], body mass index 25.3 kg/m 2 CI 24.1‐26.3], peak oxygen uptake (VO 2peak ) 34.8 mL/kg/min 32.1, 37.4] were recruited randomized into six HIIT or MICT sessions within weeks. Insulin‐stimulated glucose was measured using 2‐[ 18...
The metabolic activity of human brown adipose tissue (BAT) has been previously examined using positron emission tomography (PET). aim this study was to use proton magnetic resonance spectroscopy (1H MRS) investigate whether the temperature and fat fraction (FF) BAT white (WAT) are associated with determined by deoxy-2-18F-fluoro-d-glucose (18F-FDG)-PET. Ten healthy subjects (four women, six men; 25 45 years age) were studied PET–magnetic imaging during acute cold exposure at ambient room...
Hypoxia contributes to radiotherapy resistance and more aggressive behaviour of several types cancer. This study was designed evaluate the repeatability intratumour uptake hypoxia tracer [18F]EF5 in paired PET/CT scans. Ten patients with newly diagnosed head neck cancer (HNC) received three static scans before chemoradiotherapy: two a median 7 days apart one [18F]FDG. Metabolically active primary tumour volumes were defined [18F]FDG images transferred co-registered for analysis. A...
Abstract Inflammation plays an important role in the development of atherosclerosis and its complications. Because folate receptor β (FR-β) is selectively expressed on macrophages, FR targeted imaging agent could be useful for assessment atherosclerotic inflammation. We investigated aluminum fluoride-18-labeled 1,4,7-triazacyclononane-1,4,7-triacetic acid conjugated ( 18 F-FOL) detection plaque studied plaques mice, rabbits, human tissue samples using F-FOL positron emission...
<h3>Objective</h3> To evaluate in vivo the co-occurrence of microglial activation and microstructural white matter (WM) damage MS brain to examine their association with clinical disability. <h3>Methods</h3> 18-kDa translocator protein (TSPO) PET imaging was performed for evaluation by using radioligand [<sup>11</sup>C](R)-PK11195. TSPO binding evaluated as distribution volume ratio (DVR) from dynamic images. Diffusion tensor (DTI) conventional MRI (cMRI) were at same time. Mean fractional...
We tested the hypothesis that sprint interval training (SIT) causes larger improvements in glucose and free fatty acid uptake (FFAU) lower upper body muscles than moderate-intensity (MIT). Twenty-eight healthy, untrained, middle-aged men were randomized into SIT ( n = 14, 4–6 × 30 s of all-out cycling/4 min recovery) MIT groups [ 40–60 cycling at 60% peak O 2 (V̇o )] completed six sessions within wk. Pre- postmeasurements included V̇o , whole (M-value), muscle-specific insulin-stimulated...
Glucolipotoxicity is believed to induce pancreatic β-cell dysfunction in obesity. Previously, it has not been possible study metabolism and blood flow humans. The objective of the was investigate whether are altered obesity using positron emission tomography (PET). In preclinical part, method validated animals. This a cross-sectional study. conducted clinical research center. Human studies consisted 52 morbidly obese 25 healthy age-matched control subjects. Validation experiments were done...
Diabetic kidney disease (DKD) remains one of the leading causes premature death in diabetes. DKD is classified on albuminuria and reduced function (estimated glomerular filtration rate (eGFR)) but these have modest value for predicting future renal status. There an unmet need biomarkers that can be used clinical settings which also improve prediction decline top routinely available data, particularly early stages. The iBEAt study BEAt-DKD project aims to determine whether imaging (magnetic...
Except for aging, carrying the APOE ε4 allele (APOE4) is most important risk factor sporadic Alzheimer's disease. APOE4 carriers may have reduced capacity to recycle lipids, resulting in white matter microstructural abnormalities. In this study, we evaluated whether impairment measured by diffusion tensor imaging (DTI) differs between healthy individuals with a different number of alleles, and associates brain beta-amyloid (Aβ) load serum levels neurofilament light chain (NfL). We studied 96...
Epicardial (EAT) and pericardial (PAT) fat masses myocardial triglyceride content (MTC) are enlarged in obesity insulin resistance. We studied whether the high-intensity interval training (HIIT) moderate-intensity continuous (MICT) similarly decrease ectopic around heart is similar healthy subjects with defective glucose tolerance (DGT).A total of 28 men (body mass index = 20.7-30.0 kg·m, age 40-55 yr) 16 DGT 23.8-33.5 43-53 were randomized into HIIT MICT interventions for 2 wk. EAT PAT...
Changes in liver fatty acid metabolism are important understanding the mechanisms of diabetes remission and metabolic changes after bariatric surgery.Liver uptake (LFU), blood flow, fat content (LFC) were measured 25 obese subjects before surgery 6 months using positron emission tomography/computed tomography MRS; 14 lean individuals served as control subjects.The increased LFU was associated with body adiposity. reduced postoperatively but still high compared subjects. LFC normalized. Liver...
To study myocardial substrate uptake, structure and function, before after bariatric surgery, to clarify the interaction between metabolism cardiac remodelling in morbid obesity.We studied 46 obese patients (age 44 ± 10 years, body mass index [BMI] 42 4 kg/m2 ), including 18 with type 2 diabetes (T2D) 6 months surgery 25 healthy age-matched control group subjects. Myocardial fasting free fatty acid uptake (MFAU) insulin-stimulated glucose (MGU) were measured using positron-emission...
Assessment of myocardial viability is often needed in patients with chest pain and reduced ejection fraction. We evaluated the performance resting MBF, perfusable tissue fraction (PTF), index (PTI) assessment a pig model infarction (MI).