A5029864070- Medical Imaging Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- PARP inhibition in cancer therapy
- Peptidase Inhibition and Analysis
- Lung Cancer Research Studies
- Pancreatic and Hepatic Oncology Research
- Radiopharmaceutical Chemistry and Applications
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Nanoplatforms for cancer theranostics
- Neuroblastoma Research and Treatments
- Adipose Tissue and Metabolism
- Advanced MRI Techniques and Applications
- Neurotransmitter Receptor Influence on Behavior
- Diet and metabolism studies
- Fluorine in Organic Chemistry
- Fibroblast Growth Factor Research
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Neuropeptides and Animal Physiology
- Muscle metabolism and nutrition
- DNA Repair Mechanisms
- Pharmacological Receptor Mechanisms and Effects
Turku PET Centre
2015-2024
University of Turku
2015-2024
Turku University Hospital
2012-2024
Finnish Institute for Health and Welfare
2022
University of Helsinki
2013-2022
Helsinki University Hospital
2002-2013
ETH Zurich
2013
University Hospital of Zurich
2013
Bayer (Germany)
2013
Institute for Molecular Science
2013
Bifidobacteria and lactobacilli are part of the human normal intestinal microbiota may possibly be transferred to placenta. It was hypothesized that bacteria or their components present in placenta foetus exposed them. We investigated presence bifidobacteria DNA placenta.We studied 34 placentae (25 vaginal nine caesarean deliveries) for Bifidobacterium spp. Lactobacillus rhamnosus. Cultivation used detection viable cells genus species-specific PCR DNA. No were found by cultivation....
The sources and the impact of maternal bacteria on initial inoculum intestinal microflora newborn infants remain elusive.To assess association between breast-milk fecal bifidobacteria infants' bifidobacteria.Sixty-one mother-infant pairs were included, special emphasis being placed allergic status. Bifidobacteria analysed by a direct PCR method in samples from mothers at 30-35 weeks gestation 1 month age post-partum.Fecal Bifidobacterium adolescentis bifidum colonization frequencies counts...
Abstract Purpose: A novel [68Ga]-labeled DOTA-4-amino-1-carboxymethyl-piperidine-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 peptide (BAY86-7548) having high affinity to bombesin receptor subtype II detect primary and metastatic prostate carcinoma using positron emission tomography/computed tomography (PET/CT) was synthesized evaluated for cancer. Experimental Design: In this first human study with BAY86-7548, 14 men scheduled radical prostatectomy (n = 11) or biochemical recurrence after...
The aim of this study was to evaluate 2-(2-nitro-<sup>1</sup>H-imidazol-1-yl)-<i>N</i>-(2,2,3,3,3-pentafluoropropyl)-acetamide (EF5) labeled with <sup>18</sup>F-fluorine image hypoxia in patients squamous cell carcinoma the head and neck (HNSCC). <b>Methods:</b> Fifteen HNSCC were studied. Measurement tumor blood flow followed by an <sup>18</sup>F-EF5 PET/CT scan. On a separate day, <sup>18</sup>F-FDG performed determine metabolically active volume. In 6 patients, dynamic images area...
A switch from oxidative phosphorylation to glycolysis is frequently observed in cancer cells and linked tumor growth invasion, but the underpinning molecular mechanisms controlling are poorly understood. In this report we show that Notch signaling a key regulator of cellular metabolism. Both hyper- hypoactivated induce glycolytic phenotype breast cells, although by distinct mechanisms: hyperactivated leads increased through activation phosphatidylinositol 3-kinase/AKT serine/threonine kinase...
Cancer stem cells (CSCs) are a challenge in cancer treatment due to their therapy resistance. We demonstrated that enhanced Notch signaling breast promotes self-renewal of CSCs display high glycolytic activity and aggressive hormone-independent tumor growth vivo. took advantage the phenotype dependence on designed nanoparticles target CSCs. Mesoporous silica were functionalized with glucose moieties loaded γ-secretase inhibitor, potent interceptor signaling. vitro vivo efficiently...
The relationship between the uptake of [18F]fluoroerythronitroimidazole ([18F]FETNIM), blood flow ([15O]H2O) and 2-[18F]fluoro-2-deoxyglucose ([18F]FDG) immunohistochemically determined biomarkers was evaluated in squamous-cell carcinomas head neck (HNSCC). [18F]FETNIM [18F]FDG PET were performed on separate days 15 untreated patients with HNSCC. Hypoxia imaging coupled measurement tumor using [15O]H2O. Uptake measured as tumor-to-plasma ratio (T/P) fractional hypoxic volume (FHV), that...
Imaging using affibody molecules enables discrimination between breast cancer metastases with high and low expression of HER2, making appropriate therapy selection possible. This study aimed to evaluate if the longer half-life 64 Cu (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:msub><mml:mrow><mml:mi>T</mml:mi></mml:mrow><mml:mrow><mml:mn fontstyle="italic">1</mml:mn><mml:mo>/</mml:mo><mml:mn...
Abstract Basal-like breast cancers (BLBC) are characterized by defects in homologous recombination (HR), deficient mitotic checkpoint, and high-proliferation activity. Here, we discover CIP2A as a candidate driver of BLBC. was essential for DNA damage–induced initiation mouse BLBC-like mammary tumors survival HR–defective BLBC cells. dispensable normal gland development unperturbed mitosis, but selectively progression damaged A direct interaction between repair scaffold protein TopBP1...
Quantitative 2-[(18)F]fluoro-2-deoxy-D-glucose ([(18)F]FDG) positron emission tomography (PET) has been widely used to calculate glucose utilization in skeletal muscle. FDG-PET results depend partly on the lumped constant (LC), which accounts for differences transport and phosphorylation between [(18)F]FDG glucose. In this study, we estimated LC directly normal insulin-resistant obese subjects by combining FDG PET with microdialysis technique. Eight [age 29.4 +/- 1.0 yr, body mass index...
Hypoxia contributes to radiotherapy resistance and more aggressive behaviour of several types cancer. This study was designed evaluate the repeatability intratumour uptake hypoxia tracer [18F]EF5 in paired PET/CT scans. Ten patients with newly diagnosed head neck cancer (HNC) received three static scans before chemoradiotherapy: two a median 7 days apart one [18F]FDG. Metabolically active primary tumour volumes were defined [18F]FDG images transferred co-registered for analysis. A...
Rationale: Olfactory ensheathing cell (OEC) transplantation has emerged as a promising therapy for spinal cord injury (SCI) repair.In the present study, we explored possible mechanisms of OECs underlying neuroinflammation modulation.Methods: Spinal inflammation after intravenous OEC was detected in vivo and ex by translocator protein PET tracer [ 18 F]F-DPA.To track transplanted cells, were transduced with enhanced green fluorescent (eGFP) HSV1-39tk using lentiviral vector monitored...
The aim of this study was to compare a non-invasive 18 F-fluoromisonidazole ([ F]FM ISO) PET assessment tumour hypoxia with invasive Eppendorf pO 2 measurements in 150-1500 mm 3 C3H mammary carcinomas transplanted on the back CDF1 mice. tumour-bearing mice breathed either carbogen gas (95% oxygen, 5% CO ) or normal air during both examinations. Additional autoradiography performed separate tumours treated similarly. [18F]FM ISO examination significantly discriminated between and...
Extracellular superoxide dismutase (SOD3) gene therapy has been shown to attenuate tissue damages and improve the recovery of injuries, but cellular events delivering therapeutic response enzyme are not well defined. In current work, we overexpressed SOD3 in rat hindlimb ischemia model study signal transduction injury healing following sod3 transfer. The data suggest a novel transfer–derived cascade through Ras-Mek-Erk mitogenic pathway leading activation AP1 CRE transcription factors,...
Zoledronic acid (ZOL) is a nitrogen-containing bisphosphonate used for the treatment of bone diseases and calcium metabolism. Anticancer activity ZOL has been established, but its extraskeletal effects are limited due to rapid uptake accumulation hydroxyapatite. In this work, we report on development tethered lipid bilayer-gated mesoporous silica nanocarriers (MSNs) incorporation, retention, intracellular delivery ZOL. The in vitro anticancer ZOL-loaded was evaluated by cell viability assay...