A5051704502- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- X-ray Spectroscopy and Fluorescence Analysis
- Nuclear Physics and Applications
- Diet and metabolism studies
- Peptidase Inhibition and Analysis
- Electron and X-Ray Spectroscopy Techniques
- Cancer, Hypoxia, and Metabolism
- Monoclonal and Polyclonal Antibodies Research
- Cultural Heritage Materials Analysis
- Medical Imaging and Pathology Studies
- Adipose Tissue and Metabolism
- Advanced MRI Techniques and Applications
- Bone and Joint Diseases
- Brain Metastases and Treatment
- Advanced biosensing and bioanalysis techniques
- Neuroinflammation and Neurodegeneration Mechanisms
- Fluorine in Organic Chemistry
- Chemical Synthesis and Analysis
- Analytical chemistry methods development
- Pancreatic function and diabetes
- Graphene and Nanomaterials Applications
- Hematological disorders and diagnostics
- HER2/EGFR in Cancer Research
- Radioactive element chemistry and processing
Åbo Akademi University
2015-2025
Turku PET Centre
2015-2025
University of Turku
2011-2024
Turku University Hospital
2022
Imaging using affibody molecules enables discrimination between breast cancer metastases with high and low expression of HER2, making appropriate therapy selection possible. This study aimed to evaluate if the longer half-life 64 Cu (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:msub><mml:mrow><mml:mi>T</mml:mi></mml:mrow><mml:mrow><mml:mn fontstyle="italic">1</mml:mn><mml:mo>/</mml:mo><mml:mn...
Abstract Introduction Doxorubicin is a chemotherapeutic drug used to treat various cancers. Exercise training (ET) can attenuate some cardiotoxic effects of doxorubicin (DOX) in tumor-free animals. However, the ET on cardiac function and glucose metabolism DOX-treated breast cancer models remain unclear. Objectives This study investigated ET-induced structural, functional, vascular, oxidative stress, plausible uptake alterations left ventricle (LV) murine model during DOX treatment. Methods...
Folate receptors (FRs), membrane-bound proteins that bind specifically to folate with high affinity, are overexpressed by various cancer types and therefore used as targets for delivery of therapeutic agents. Molecular spherical nucleic acids (MSNAs) dendritic formulations oligonucleotides (ONs) may have advantages over linear parent ONs respect properties. Here, we assembled folate-decorated MSNAs, site-specifically radiolabeled them, then biologically evaluated their effects in mice...
Many neurological conditions result in the overexpression of translocator protein 18 kDa (TSPO), today recognized as a biomarker for microglial activation and neuroinflammation imaging. The pyrazolo[1,5-a]pyrimidine acetamides are particularly attractive class TSPO-specific ligands, prompting development several positron emission tomography (PET) radiotracers. This includes F-DPA, recently reported fluorinated ligand (K i = 1.7 nM), wherein fluorine atom is directly linked to phenyl moiety...
Neuroinflammation is associated with several neurological disorders, including Alzheimer's disease (AD). The translocator protein 18 kDa (TSPO), due to its overexpression during microglial activation and relatively low levels in the brain under normal neurophysiological conditions, commonly used as an vivo biomarker for neuroinflammation. Reported here preclinical evaluation of [18F]F-DPA, a promising new TSPO-specific radioligand, tool detection activated microglia at different ages...
Overexpression of the epidermal growth factor receptor (EGFR) is linked to an adverse outcome in various solid tumors. Cetuximab EGFR inhibitor, which combination with radiotherapy improves locoregional control and survival a subgroup patients head neck squamous cell carcinomas (HNSCCs). The aim this study was develop characterize EGFR‐directed PET tracer, 64 Cu‐cetuximab‐F(ab′) 2 , determine systemic accessibility EGFR. Mice HNSCC xenografts, UT‐SCC‐8 ( n = 6) or UT‐SCC‐45 6), were imaged...
Abstract Myocardial infarction (MI) is the leading cause of death worldwide. However, current therapies are unable to restore function injured myocardium. Advanced approaches, such as stimulation cardiomyocyte (CM) proliferation promising, but suffer from poor pharmacokinetics and possible systemic adverse effects. Nanomedicines can be a solution above‐mentioned drawbacks. targeting cardiac tissue still represents challenge. Herein, MI‐selective precision nanosystem developed, that relies on...
In the development of new 18F-labelled tracers, it is important to assess amount released [18F]fluoride taken up in bones experimental animals because all PET-tracers are prone, lesser or higher degree, undergo defluorination, with subsequent release during scanning. However, pharmacokinetics and other organs healthy rats have not been well documented a comprehensive manner. We aimed study [18F]NaF order increase our understanding biodistribution originating from defluorination tracers....
18F-Labeled [60]fullerene-based molecular spherical nucleic acids (MSNAs), consisting of a human epidermal growth factor receptor 2 (HER2) mRNA antisense oligonucleotide sequence with native phosphodiester and phosphorothioate backbone, were synthesized, site-specifically labeled positron emitting fluorine-18 intravenously administrated via tail vein to HER2 expressing HCC1954 tumor-bearing mice. The biodistribution the MSNAs was monitored in vivo by emission tomography/computed tomography...
The model complex [64Cu((S)-p-NH2-Bn-NOTA)]− ([64Cu]1) was used to study the isomerism of [64Cu-NOTA-Bn]-labeled radiotracers. Two isomers [64Cu]1a and [64Cu]1b, which were formed at a ratio 1:9 during complexation [64Cu]Cu2+ with (S)-p-NH2-Bn-NOTA, separated using ion pair chromatography. To interconversion, nonradioactive Cu1a Cu1b thermally treated 90 °C in both ammonium acetate solution deionized water. A faster interconversion rate observed for lower concentrations ions. At end...
[ 18 F]F-DPA, a novel translocator protein kDa (TSPO)-specific radioligand for imaging neuroinflammation, has to date been synthesized with low moderate molar activities (A m ’s). In certain cases, A can skew the estimation of specific binding. The high proportion non-radioactive component reduce apparent-specific binding by competitively receptors. We developed nucleophilic synthesis F]F-DPA resulting in (990 ± 150 GBq/µmol) and performed vivo comparison (9.0 2.9 same APP/PS1-21 wild-type...
The aim was to study brain innate immune cell activation in teriflunomide-treated patients with relapsing-remitting multiple sclerosis.Imaging 18-kDa translocator protein positron emission tomography (TSPO-PET) using the [11 C]PK11195 radioligand employed assess microglial activity white matter, thalamus and areas surrounding chronic matter lesions 12 sclerosis who had been treated teriflunomide for at least 6 months before inclusion. Magnetic resonance imaging (MRI) used measure lesion load...
Introduction Non-invasive imaging techniques such as positron emission tomography (PET) are extremely important for cancer detection and characterization especially difficult to biopsy or delicate organs the brain. The folate analogue 1,4,7-triazacylononane-1,4,7-triacetic acid-conjugated radiolabeled with aluminum fluoride-18 ([ 18 F]FOL) has been previously shown accumulate preferentially in tumor cells an overexpression of receptors (FRs) here was investigated its ability detect...
Pretargeted concept in positron emission tomography (PET) together with bioorthogonal chemistry is an elegant solution to study processes slow pharmacokinetics by utilizing radiotracers labeled short-lived radionuclides. Namely, based on tetrazine ligation trans-cyclooctene (TCO) via the inverse electron demand Diels–Alder (IEDDA) reaction have become a state-of-the-art for pretargeted PET imaging. For radiolabeling of scaffolds, indirect radiofluorination methods are often preferred, as...
Abstract Aims/hypothesis Stem cell-derived islets (SC-islets) are being used as cell replacement therapy for insulin-dependent diabetes. Non-invasive long-term monitoring methods SC-islet grafts, which needed to detect misguided differentiation in vivo and optimise their therapeutic effectiveness, lacking. Positron emission tomography (PET) has been monitor transplanted primary islets. We therefore aimed apply PET a non-invasive method grafts. Methods implanted different doses of human...
The use of long-lived positron emitters 64Cu or 61Cu for labelling Affibody molecules may improve breast cancer patients' stratification HER-targeted therapy. Previous animal studies have shown that the triaza chelators synthetic is suboptimal. In this study, we tested a hypothesis cross-bridged chelator, CB-TE2A, in combination with Gly-Glu-Glu-Glu spacer radiocopper would imaging contrast. CB-TE2A was coupled to N-terminus extended either glycine (designation CB-TE2A-G-ZHER2:342)...