A5029382158- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Coronary Interventions and Diagnostics
- ECG Monitoring and Analysis
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Cardiovascular Effects of Exercise
- Acute Myocardial Infarction Research
- Ion channel regulation and function
- Cardiomyopathy and Myosin Studies
- Venous Thromboembolism Diagnosis and Management
- MicroRNA in disease regulation
- Genetics and Neurodevelopmental Disorders
- Cardiac Fibrosis and Remodeling
- Angiogenesis and VEGF in Cancer
- RNA modifications and cancer
- Cerebrovascular and Carotid Artery Diseases
- SARS-CoV-2 and COVID-19 Research
- COVID-19 and healthcare impacts
- Circular RNAs in diseases
- Lipoproteins and Cardiovascular Health
- Tissue Engineering and Regenerative Medicine
- Atherosclerosis and Cardiovascular Diseases
University of Calabria
2024-2025
Ospedale Annunziata di Cosenza
2025
NYU Langone Health
2025
Magna Graecia University
2015-2024
Politecnico di Milano
2024
Creative Commons
2023
Azienda Ospedaliero Universitario Mater Domini
2023
GTx (United States)
2023
Società Italiana di Cardiologia
2021-2022
Clinica Mediterranea
2020
Abstract Aims To evaluate the impact of COVID-19 pandemic on patient admissions to Italian cardiac care units (CCUs). Methods and Results We conducted a multicentre, observational, nationwide survey collect data for acute myocardial infarction (AMI) at CCUs throughout 1 week period during outbreak, compared with equivalent in 2019. observed 48.4% reduction AMI 2019 (P < 0.001). The was significant both ST-segment elevation [STEMI; 26.5%, 95% confidence interval (CI) 21.7–32.3; P =...
MicroRNA (miR)-1 and -133 play a crucial role in skeletal cardiac muscle biology pathophysiology. However, their expression regulation vascular cell physiology disease is currently unknown.The aim of the present study was to evaluate role, if any, miR-1 miR-133 smooth (VSMC) phenotypic switch vitro vivo.We demonstrate here that robustly expressed cells (VSMCs) vivo, whereas levels are negligible. has potent inhibitory on VSMC does not have any relevant effect per se. regulated by...
This study intends to gain further insights into the natural history, yield of familial and genetic screening, arrhythmogenic mechanisms in largest cohort short QT syndrome (SQTS) patients described so far.SQTS is a rare disorder associated with life-threatening arrhythmias, its history incompletely ascertained.Seventy-three SQTS (84% male; age, 26 ± 15 years; corrected interval, 329 22 ms) were studied, 62 followed for 60 41 months (median, 56 months).Cardiac arrest (CA) was most frequent...
A hyperadrenergic state is a seminal aspect of chronic heart failure. Also, "Takotsubo stress cardiomyopathy," associated with increased plasma catecholamine levels. The mechanisms myocyte damage secondary to excess exposure as well the consequence this neurohumoral burst on cardiac stem cells (CSCs) are unknown. Cardiomyocytes and CSCs were exposed high doses isoproterenol (ISO), in vivo vitro. Male Wistar rats received single injection ISO (5 mg kg-1) sacrificed 1, 3, 6 days later. In...
Background— Catecholaminergic polymorphic ventricular tachycardia is an inherited arrhythmogenic disorder characterized by sudden cardiac death in children. Drug therapy still insufficient to provide full protection against arrest, and the use of implantable defibrillators pediatric population limited side effects. There therefore a need explore curative potential gene for this disease. We investigated efficacy durability viral transfer calsequestrin 2 ( CASQ2 ) wild-type catecholaminergic...
Phenotypic switch of vascular smooth muscle cells (VSMCs) plays a key role in the pathogenesis different diseases, such as atherosclerosis and restenosis after coronary intervention. MicroRNAs have been identified regulators VSMC biology. The miR-23b is highly expressed VSMCs it involved differentation, proliferation, migration several non-vascular cell types. However, disease currently unknown. Thus, aim present study was to evaluate on phenotypic vitro injury vivo. To determine changes...
Acute coronary syndromes are the leading cause of death worldwide and disease burden in high-income countries. Quick accurate diagnosis acute is essential to avoid fatal events, for timely intervention, improve prognosis.To prospectively investigate feasibility accuracy a smartwatch recording multiple electrocardiographic (ECG) leads detecting ST-segment changes associated with compared standard 12-lead ECG.A commercially available was used 100 participants obtain multiple-channel ECGs. The...
Abstract The propensity of circulating particles to drift laterally towards the vessel walls (margination) in microcirculation has been experimentally studied using a parallel plate flow chamber. Fluorescent polystyrene particles, with relative density water just 50 g/cm 3 comparable that liposomal or polymeric nanoparticles used drug delivery and bio-imaging, have diameter spanning over three order magnitudes from nm up 10 μm . number <mml:math...
The beta-adrenergic receptor (betaAR) signaling system is one of the most powerful regulators cardiac function and a key regulator Ca(2+) homeostasis. We investigated role betaAR stimulation in augmenting its activation Ca(2+)/calmodulin-dependent kinase II (CaMKII) using various knockouts (KO) including beta(1)ARKO, beta(2)ARKO, beta(1)/beta(2)AR double-KO (DKO) mice. employed murine model left anterior descending coronary artery ligation to examine differential contributions specific...
Downregulation of the muscle-specific microRNA-1 (miR-1) mediates induction pathologic cardiac hypertrophy. Dysfunction gap junction protein connexin 43 (Cx43), an established miR-1 target, during hypertrophy leads to ventricular tachyarrhythmias (VT). However, it is still unknown whether and Cx43 are interconnected in pro-arrhythmic context Thus, this study we investigated a reduction extent could limit pathological electrical remodeling onset VT by modulating levels. Wistar male rats...
Patients with cardiac hypertrophy are at increased cardiovascular risk. It has been hypothesized that hydroxymethylglutaryl coenzyme A reductase inhibitors may exert beneficial effects other than their cholesterol-lowering actions. The aims of the study were to assess in vivo simvastatin (SIM) on and Ras signaling rats ascending aorta banding.Wistar randomized receive either treatment SIM or placebo, then short-term (group I) long-term II) left ventricular pressure overload was performed by...
The HMGA1 protein is a major factor in chromatin architecture and gene control. It plays critical role neoplastic transformation. In fact, blockage of synthesis prevents rat thyroid cell transformation by murine transforming retroviruses, an adenovirus carrying the antisense orientation induces apoptotic death anaplastic human carcinoma lines, but not normal cells. Moreover, both vitro vivo studies have established oncogenic gene. this study, to define function vivo, we examined consequences...
Recommendations concerning the continuation of chemotherapy in nonresponding patients with non-small cell lung cancer (NSCLC) and stable disease after first test are empirical often conflicting. Between 1984 1987, 116 inoperable NSCLC were treated methothrexate, doxorubicin, cyclophosphamide, lomustine (MACC regimen). After two or three cycles therapy, 74 judged to have assigned at random either maintenance same regimen (38 subjects) discontinuation (36 subjects). The study groups comparable...
One hundred six patients with histologically proven bronchogenic carcinoma were tested for carcinoembryonic antigen (CEA), tissue polypeptide (TPA), and carbohydrate antigenic determinant 19-9 (CA19-9). A total of 349 CEAs, 350 TPAs, 317 CA19-9s measured. In addition, sera assayed from 57 pulmonary benign diseases their CEA, TPA, CA19-9 levels used as negative controls specificity accuracy. twenty healthy subjects provided our normal reference value. Sensitivity, specificity, accuracy...
The inherited and acquired long QT is a risk marker for potential serious cardiac arrhythmias sudden death. Smartwatches are becoming more popular increasingly used monitoring human health. present study aimed to assess the feasibility reliability of evaluating interval in lead I, II, V2 using commercially available Apple Watch. One hundred nineteen patients admitted our Cardiology Division were studied. leads obtained after recording standard 12-lead ECG. Lead I was recorded with smartwatch...
Patients with cardiomyopathies and channelopathies are usually younger have a predominantly arrhythmia-related prognosis; they nearly normal life expectancy thanks to the protection against sudden cardiac death provided by implantable cardioverter defibrillator (ICD). The subcutaneous ICD (S-ICD) is an effective alternative transvenous has evolved over years. This study aimed evaluate rate of inappropriate shocks (IS), appropriate therapies, device-related complications in patients who...