A5100754310- Cancer Immunotherapy and Biomarkers
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Mechanisms and Therapy
- Asthma and respiratory diseases
- RNA modifications and cancer
- Inflammatory Biomarkers in Disease Prognosis
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Surgical Treatments
- Immune cells in cancer
- Nitric Oxide and Endothelin Effects
- Lung Cancer Research Studies
- Immune Cell Function and Interaction
- Cancer Cells and Metastasis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer therapeutics and mechanisms
- Peptidase Inhibition and Analysis
- Fungal Biology and Applications
- Pancreatic and Hepatic Oncology Research
- Atherosclerosis and Cardiovascular Diseases
- Polysaccharides and Plant Cell Walls
- Ferroptosis and cancer prognosis
- Immune Response and Inflammation
- Cancer, Lipids, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
Shanxi Agricultural University
2023-2025
Peking Union Medical College Hospital
2022-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
Peking University
2023-2024
Chinese PLA General Hospital
2023-2024
Zhejiang Chinese Medical University
2024
Guangdong Pharmaceutical University
2019-2024
Shanxi Medical University
2021-2024
Second Affiliated Hospital of Xi'an Jiaotong University
2024
Peking University Cancer Hospital
2024
Background Tertiary lymphoid structures (TLSs) are crucial in promoting and maintaining positive anti-tumor immune responses. The tumor stroma has a powerful immunosuppressive function that could exclude tumor-infiltrating lymphocytes from the beds lead to “cold” phenotype. TLSs percentage (TSP) significantly associated with prognosis of patients certain cancers. However, exact roles TSP their intrinsic relationship still largely unknown colorectal cancer (CRC). Methods were assessed using...
Abstract Tertiary lymphoid structure (TLS) contributes to the anti-tumor immune response, and predicts prognosis of colorectal cancer patients. However, potential impact TLS in shaping status rectal adenocarcinoma, intrinsic relationship between neoadjuvant therapies (neoTx) remain unclear. We performed hematoxylin-eosin staining, immunohistochemical biomolecular analyses investigate tumor-infiltrating lymphocytes (TILs) 221 neoTx-treated 242 treatment-naïve locally advanced (LARC) High...
Abstract Objective In this positron emission tomography (PET) study with [ 11 C]UCB‐J, we evaluated synaptic vesicle glycoprotein 2A (SV2A) binding, which is decreased in resected brain tissues from epilepsy patients, subjects temporal lobe (TLE) and compared the regional binding pattern to 18 F]fluorodeoxyglucose (FDG) uptake. Methods Twelve TLE 12 control were examined. Regional C]UCB‐J potential ( BP ND ) values estimated using centrum semiovale as a reference region. F]FDG uptake was...
Rapid diagnosis of kidney bean leaf spot disease is crucial for ensuring crop health and increasing yield. However, traditional machine learning methods face limitations in feature extraction, while deep approaches, despite their advantages, are computationally expensive do not always yield optimal results. Moreover, reliable datasets remain scarce. To address these challenges, this study constructs the first-ever (KBLD) dataset, filling a significant gap field. Based on novel hybrid model...
Alpha-fetoprotein (AFP) has been established as a biomarker for hepatocellular carcinoma (HCC); however, whether its dynamic changes could predict the response to systemic therapy remains elusive. This study explored AFP trajectory and association with survival in patients received bevacizumab plus immunotherapy. We retrospectively enrolled 536 HCC immunotherapy between February 2021 2023. Patients were divided into two groups according values before treatment (400 ng/ml). Dynamic of fitted...
A growing body of research indicates significant differences between left-sided colon cancers (LCC) and right-sided (RCC). Pan-immune-inflammation value (PIV) is a systemic immune response marker that can predict the prognosis patients with cancer. However, specific distinction PIV LCC RCC remains unclear.
The kidney bean is an important cash crop whose growth and yield are severely affected by brown spot disease. Traditional target detection models cannot effectively screen out key features, resulting in model overfitting weak generalization ability. In this study, a Bi-Directional Feature Pyramid Network (BiFPN) Squeeze Excitation (SE) module were added to YOLOv5 improve the multi-scale feature fusion extraction abilities of improved model. results show that BiFPN SE modules higher heat...
The use of ketamine, an anesthetic, as a treatment for asthma has been investigated in numerous studies. However, how ketamine affects is unclear. present study examined the effects on murine model mixed-granulocytic asthma, and role nuclear factor erythroid 2-related 2 (Nrf2) pathway.The was established using ovalbumin (OVA) sensitization combination OVA lipopolysaccharides (LPS) challenge. main characteristics oxidative stress biomarkers, expression Nrf2 pathway were examined. ML385...
Diallyl disulfide (DADS) is one of the primary components garlic and it exhibits a broad range biological activities. In present study, effects DADS on lipid metabolism its potential role in modulation gut microbiome were determined. Hematoxylin eosin oil‑red O staining used to assess liver intestinal tissues mice treated with DADS. The expression metabolism‑associated genes was measured using reverse transcription‑quantitative PCR (RT‑qPCR). 16S recombinant (r)DNA gene analysis. results...
Asthma is a common respiratory disease characterized by chronic airway inflammation. Dexmedetomidine (DEX), highly selective α2 adrenergic receptor agonist, has been shown to participate in regulating inflammatory states and thus exert organ protective actions. However, the potential of DEX asthma still unknown. This study aimed at investigating role mouse model house dust mite- (HDM-) induced exploring its underlying mechanism. Here, we found that treatment significantly ameliorated...
The normal IgG, a circulating antibody, is maintained at constant level in humans. However, little known regarding whether IgG has effects on the function of vascular endothelial cells. purpose this study was to investigate affects superoxide (O(2)(·-)) generation and cell permeability human aortic cells (HAECs) isolated from hypertensive patient. effect investigated cultured HAECs patient who died stroke. results demonstrated, for first time, that attenuated intracellular O(2)(·-) decreased...
Small cell lung cancer (SCLC) was defined as a recalcitrant cancer, and novel therapies are urgently needed. Marine natural products (MNPs) may bring continuing hope for treatment of SCLC. In this study, 3-bromoascochlorin (BAS), an MNP isolated from the coral-derived fungus Acremonium sclerotigenum GXIMD 02501, primarily screened out with antiproliferative activity towards SCLC lines. Then western blot analysis (WB) flow cytometry were conducted, we found BAS could induce apoptosis H446...
Purpose: To demonstrate the intrinsic association of Neutrophil extracellular traps (NETs) with outcome and neoadjuvant therapy response locally advanced rectal cancer (LARC), mechanisms. Patients Methods: We enrolled 240 patients LARC who underwent surgery without in two independent sets (training validation), 153 received biopsy followed by surgery. Immunohistochemistry, immunofluorescence staining bioinformatics analysis were performed formalin-fixed paraffin-embedded sections. NETs...
Abstract Boosting anti-tumor immune responses can be achieved by activating the innate system. Despite ongoing development of numerous STING and TLR agonists for this purpose, none them have progressed to late-stage clinical evaluation. Alpha protein kinase-1 (ALPK1) is an intracellular receptor newly identified its ability detect ADP-heptose, a metabolite released during biosynthesis degradation lipopolysaccharides (LPS). Since heptose not naturally present in mammalian cells, recognition...
HLA-B*39:06, HLA-B*39:01, and HLA-B*38:01 are closely related HLA allotypes differentially associated with type 1 diabetes (T1D) risk progression. B*39:06 is highly predisposing, while B*39:01 B*38:01 weakly predisposing protective allotypes, respectively. Here, we aimed to decipher molecular mechanisms underlying the differential association of these T1D pathogenesis. We addressed peptide binding conformational stability HLA-B using computational experimental approaches. Computationally,...
Abstract Cachexia, which affects 50–80% of cancer patients, is a debilitating syndrome that leads to 20% cancer-related deaths. A key feature cachexia adipose tissue atrophy, but how it contributes the development poorly understood. Here, we demonstrate in mouse models white browning, can be characteristic early-onset manifestation, occurs prior loss body weight and skeletal muscle wasting. By analysing proteins differentially expressed extracellular vesicles derived from cachexia-inducing...
Background Transarterial therapy (TAT), bevacizumab (Bev), and immune checkpoint inhibitors (ICIs) have individually exhibited efficacy in treating advanced-stage hepatocellular carcinoma (HCC). This study aimed to assess the safety of combination these three treatments as a neoadjuvant modality patients with locally advanced HCC. Methods The primary endpoint is overall survival (OS). second progression free (PFS), objective response rate (ORR), pathological safety. Results A total 54...
Dexmedetomidine (DEX) suppresses inflammatory responses and protects against organ injury. The aim of the present study was to investigate effect DEX on airway hyperresponsiveness (AHR) allergic inflammation, as well its underlying mechanism action in a murine model ovalbumin (OVA)‑induced asthma. A total 30 female BALB/c mice were divided into 6 groups (n=5 mice/group): Control, OVA, OVA + (20, or 50 µg/kg) TAK‑242 [a toll‑like receptor 4 (TLR4) inhibitor]. intraperitoneally injected with...
Introduction: Monoclonal antibody (mAb) is an important treatment option for cancer patients and has received widespread attention in recent years. In this context, a comparative safety evaluation of mAbs traditional anticancer drugs real-world warranted. Methods: ADR reports submitted to Henan Adverse Drug Reaction Monitoring Center from 2016 2020 individuals taking antineoplastic were included. Data analyzed with respect demographic characteristics, disease types, polypharmacy, past...