A5077065100- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Traumatic Brain Injury and Neurovascular Disturbances
- Venous Thromboembolism Diagnosis and Management
- Thermal Regulation in Medicine
- Photoacoustic and Ultrasonic Imaging
- Intracerebral and Subarachnoid Hemorrhage Research
- Peripheral Artery Disease Management
- Intracranial Aneurysms: Treatment and Complications
- Atrial Fibrillation Management and Outcomes
- Infrared Thermography in Medicine
- Healthcare cost, quality, practices
- Retinal Imaging and Analysis
- Retinal Diseases and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Ocular Surface and Contact Lens
- Allergic Rhinitis and Sensitization
- Ultrasound in Clinical Applications
- Clinical Reasoning and Diagnostic Skills
- Blood Coagulation and Thrombosis Mechanisms
- Spinal Cord Injury Research
- Vasculitis and related conditions
- Cardiac Arrest and Resuscitation
- Iron Metabolism and Disorders
University of Calgary
2024-2025
University of Auckland
2017-2025
Foothills Medical Centre
2024
Royal North Shore Hospital
2023-2024
Westmead Hospital
2023-2024
Auckland District Health Board
2024
Auckland City Hospital
2019-2023
North Shore Hospital
2023
Middlemore Hospital
2020
Neurology, Inc
2019
Abstract Objective Implementation of machine learning (ML) may be limited by patients’ right to “meaningful information about the logic involved” when ML influences healthcare decisions. Given complexity decisions, it is likely that outputs will need understood and trusted physicians, then explained patients. We therefore investigated association between physician understanding outputs, their ability explain these patients, willingness trust using various explainability methods. Materials...
BackgroundWhether the large effect size of endovascular thrombectomy (EVT) for stroke due to large-vessel occlusion applies medium-vessel is unclear.MethodsIn a multicenter, prospective, randomized, open-label trial with blinded outcome evaluation, we assigned patients acute ischemic who presented within 12 hours from time that they were last known be well and had favorable baseline noninvasive brain imaging receive EVT plus usual care or alone. The primary was modified Rankin scale score...
In ischemic stroke, intravenous tenecteplase is noninferior to alteplase in selected patients and has some practical advantages. Several stroke centers New Zealand changed routine off-label due improved early recanalization large vessel occlusion, inconsistent access thrombectomy within networks, for consistency treatment protocols between with without occlusion. We report the feasibility safety outcomes tenecteplase-treated patients.We performed a retrospective analysis of consecutive...
Background and Purpose— In ischemic stroke, baseline renal impairment is present in 20 to 35% of patients may increase the risk contrast-associated acute kidney injury (CA-AKI). We aimed determine whether endovascular thrombectomy (EVT) with are at increased CA-AKI. Methods— Consecutive EVT were identified from a prospective database. Patients stratified by estimated glomerular filtration rate. The primary outcome was CA-AKI assessed 24 72 hours following EVT, defined as an serum creatinine...
Introduction Endovascular thrombectomy (EVT) has revolutionized the treatment of patients with large vessel occlusion (LVO) stroke. Three-month functional independence ranges between 33 and 60%, mortality 12 25%. Few studies have presented outcomes beyond five years their reported odds or hazard ratios are difficult to apply clinically. Median survival is also challenging interpret correctly. Restricted mean time (RMST) a clinically intuitive metric that gives times up specified cutoff...
Abstract Patients with large infarct cores on imaging at hospital presentation who are then treated endovascular thrombectomy achieved functional independence rates ranging from 14%–30% in randomised controlled trials. We describe our ‘real‐world’ experience these patients. About one‐third were independent day 90, similar to trial results. This was associated higher of complications and double the length stay.
Background and Purpose— Methods of identifying ischemic stroke patients with a greater probability poor outcome following endovascular thrombectomy (EVT) might improve shared treatment decision-making between patients, families, physicians. We used an objective, automated method to measure cerebral atrophy investigated whether this was associated in EVT patients. Methods— Consecutive from single-center registry were studied. CT brain scans segmented combination validated U-Net Hounsfield...
Background In ischemic stroke, increased glycated hemoglobin (HbA1c) and glucose levels are associated with worse outcome following thrombolysis, possibly, endovascular thrombectomy. Objective To evaluate the association between admission HbA1c Methods Consecutive patients treated thrombectomy were included. The primary was functional independence, defined as a modified Rankin Scale score of 0–2 at 3 months. Secondary outcomes included successful reperfusion (modified Thrombolysis in...
Background and Purpose— In ischemic stroke, body temperature is associated with functional outcome. However, the relationship between outcome may differ in intraischemic postischemic phases of stroke. We aimed to determine whether before or after endovascular thrombectomy (EVT) for large vessel occlusion stroke clinical outcomes. Methods— Consecutive EVT patients were identified from a prospective registry. Temperature measurements within 24 hours admission stratified into pre-EVT...
Patient outcome after stroke is frequently assessed with clinical scales such as the modified Rankin Scale score (mRS). Days alive and out of hospital at 90 days (DAOH-90), which measures survival, time spent in or rehabilitation settings, readmission institutionalization, an objective measure that can be obtained from large administrative data sets without need for patient contact. We aimed to assess comparability DAOH mRS its relationship other prognostic variables acute reperfusion therapy.
The choice of anesthetic technique for ischemic stroke patients undergoing endovascular thrombectomy is controversial. Intravenous propofol and volatile inhalational general agents have differing effects on cerebral hemodynamics, which may affect brain tissue clinical outcome. We compared outcomes in with anesthesia who were treated or agents.Consecutive using identified from our prospective database. Baseline patient characteristics, agent, recorded. Functional independence at 3 months was...
Deep learning using clinical and imaging data may improve pre-treatment prognostication in ischemic stroke patients undergoing endovascular thrombectomy (EVT).
It is unknown whether systolic blood pressure augmentation during endovascular thrombectomy improves clinical outcomes. This pilot randomised controlled trial aimed to assess the feasibility of differential targeting procedures for anterior circulation ischaemic stroke. Fifty-one eligible patients fulfilling national criteria were randomly assigned receive either standard or augmented management from start anaesthesia recanalisation target vessel. Systolic targets and groups 130-150 mmHg...
Active conductive head cooling is a simple and non-invasive intervention that may slow infarct growth in ischemic stroke. We investigated the effect of active on brain temperature using whole echo-planar spectroscopic imaging. A cap (WElkins Temperature Regulation System, 2nd Gen) was used to administer for 80 minutes healthy volunteers chronic stroke patients. Whole imaging scans were obtained before after cooling. Brain estimated Metabolite Imaging Data Analysis System software package,...