A5039891659- Peripheral Neuropathies and Disorders
- Genetic Neurodegenerative Diseases
- Neurogenetic and Muscular Disorders Research
- Peripheral Nerve Disorders
- Autoimmune Neurological Disorders and Treatments
- Hereditary Neurological Disorders
- Muscle Physiology and Disorders
- Cardiomyopathy and Myosin Studies
- Inflammatory Myopathies and Dermatomyositis
- Myasthenia Gravis and Thymoma
- Long-Term Effects of COVID-19
- Ion channel regulation and function
- Cancer Immunotherapy and Biomarkers
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Amyotrophic Lateral Sclerosis Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cellular transport and secretion
- Nerve Injury and Rehabilitation
- Moyamoya disease diagnosis and treatment
- Musculoskeletal synovial abnormalities and treatments
- Hepatitis Viruses Studies and Epidemiology
- Brain Metastases and Treatment
- Ophthalmology and Eye Disorders
- Shoulder and Clavicle Injuries
- Neurological diseases and metabolism
University of Lausanne
2020-2025
University Hospital of Lausanne
2018-2025
Fondazione IRCCS Istituto Neurologico Carlo Besta
2023
Linköping University
2023
Weatherford College
2021
In the wake of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, an increasing number patients with neurological disorders, including Guillain-Barré (GBS), have been reported following this infection. It remains unclear, however, if these cases are coincidental or not, as most publications were case reports small regional retrospective cohort studies. The International GBS Outcome Study is ongoing prospective observational study enrolling within weeks from onset...
In 2024, therapeutic and diagnostic advancements are shaping the field of neurology. Three new drugs show promise for treating myasthenia gravis chronic inflammatory demyelinating polyneuropathy. A classification Parkinson's disease has been proposed, while a neuroprosthesis is improving gait in advanced stages. Revised criteria inclusion body myositis multiple sclerosis refining diagnoses, blood biomarkers enabling early detection Alzheimer's disease. The effectiveness thrombolysis stroke...
<h3>Background</h3> The prevalence of connective tissue disease (CTD) induced by immune checkpoint inhibitors (CPIs) in the absence pre-existing autoimmunity is unknown. <h3>Case presentation</h3> We report case a melanoma patient treated for 8 months with pembrolizumab who developed subacute ataxic sensory neuronopathy (SNN), including right trigeminal neuropathy. Salivary gland biopsy showed inflammatory changes suggestive Sjögren's syndrome, while brain MRI revealed enhancement...
Hereditary transthyretin-related (hATTR) amyloidosis is a rare disease, causing disabling and life-threatening axonal length-dependent polyneuropathy. Monitoring of disease progression treatment response difficult. We aimed to determine if serum neurofilament light chain (sNfL) reliable early biomarker peripheral neuropathy in hATTR amyloidosis. prospectively included 20 patients, 14 symptomatic 6 asymptomatic. Patients were assessed at baseline 1 year, including full clinical examination...
Acute hepatitis E virus (HEV) infection has recently emerged as a potential trigger for acute dysimmune neuropathies, but prospective controlled studies are lacking.
Abstract Background Immune checkpoint inhibitors (ICIs) are reshaping the prognosis of many cancers, but often cause immune-related adverse events (irAEs). Among neurological irAEs, myositis is most frequently reported. Our aim to describe clinical and non-clinical characteristics, treatment outcome all irMyositis (skeletal limb-girdle and/or ocular myositis) irMyocarditis cases in our reference center. Methods We retrospectively enrolled irMyositis/irMyocarditis patients seen between 2018...
To compare the cost of two patient management strategies with similar efficacies for chronic inflammatory demyelinating polyneuropathy (CIDP) patients in phase: hospital-based IV immunoglobulin G (IVIg) and home-based subcutaneous (SCIg) associated an interprofessional drug therapy programme (initial training follow-up).A 48-week model-based cost-minimization analysis from a societal perspective was performed. Resources included (IVIg: 1 g/kg/3 weeks; SCIg: 0.4 g/kg/week initially 0.2...
Abstract Background and purpose Infections vaccinations have been identified as potential immunological triggers of neuralgic amyotrophy (NA), but the exact type frequency preceding agents is unknown. Methods This was a multicentre, prospective, observational, matched case–control study. NA diagnosed by neuromuscular experts according to validated clinical criteria electrodiagnostic studies. Clinical data biological samples patients were collected within 90 days from disease onset between...
To report an exceptional case of nerve infiltration by otherwise benign chronic B cell leukemia, inducing severe mononeuritis multiplex.The patient underwent extensive evaluation, including conduction study and myography, brain plexus MRI, biopsy.The clinical electrophysiological diagnosis was a multiplex with motor sensory involvement; only the biopsy allowed definite introduction chemotherapy, leading to resolution deficit progressive improvement.Neuroleukemiosis caused lymphoid leukemia...
2][3] There is no report of histologic association with vasculitis.We present a case AK5 limbic encephalitis evidence CNS vasculitis. CaseA 58-year-old woman was admitted for investigation headaches, memory impairment, behavioral changes, and sleep disturbances, progressing over approximately 1 month impairing her daily activities.
Rare mechanisms of stroke (RMS) in acute ischemic (AIS) have rarely been studied applying a systematic approach. Our aim was to define the frequency, etiologies, predictors, and outcomes RMS consecutive series AIS.Data from patients 2003 2016 were derived Acute STroke Registry Analysis Lausanne (ASTRAL). Frequency subcategories calculated. In case-control design, compared strokes all other mechanisms. Outcome assessed with 3-month Rankin-shift 12-month mortality recurrence rates.Out 4154...
A 39-year-old man presented with an asymmetric distal weakness and loss of sensitivity sequentially affecting both lower extremities the left upper limb. Nerve conduction studies showed a multifocal sensory motor axonal neuropathy, pseudo-conduction block right fibular nerve, whole being consistent mononeuropathy multiplex. An uncommon etiology was found after extensive workup. Axonal severe, only partial response to treatment corticosteroids IV immunoglobulins.
A 69-year-old man was admitted from the emergency department of our hospital for subacute onset visual complaints. The evening before admission, around 10 pm, while watching TV, he experienced binocular and persistent discomposed colors in lower left field (appearing both inside outside television screen) that did not change with direction gaze. He went to bed woke up at 1 am usual nocturia; then, trying read his alarm clock, unable understand what time it despite correctly seeing numbers....
chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) has been widely described during the last quarter of twentieth century. The 20 years have seen decisive progress in its understanding. diagnostic criteria simplified and steps process clarified. phenotypic contours disease are now well known, as pitfalls. From a pathophysiological point view, discovery autoantibodies directed against nodal paranodal proteins major advance, although it concerns only minority patients. These...
Muscle cramps are very common and can reduce quality of life. There multiple causes, including some physiological conditions, metabolic, endocrine, vascular disorders or neuromuscular diseases. Adequate management first requires differentiating from other muscular phenomena. In most cases, the investigations limited to a comprehensive history clinical examination, but biological, radiological and/or electrophysiological work-up may be useful. Treatment, when needed, is often symptomatic...